BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models

Hao, Xiaoguang; Bahia, Ravinder K; Cseh, Orsolya; Bozek, Danielle A; Blake, Sophia; Rinnenthal, Jörg; Weyer-Czernilofsky, Ulrike; Rudolph, Dorothea; Artee Luchman, H

doi:10.1093/neuonc/noac271

BI-907828, a novel potent MDM2 inhibitor, inhibits glioblastoma brain tumor stem cells in vitro and prolongs survival in orthotopic xenograft mouse models

Background The tumor suppressor TP53 (p53) is frequently mutated, and its downstream effectors inactivated in many cancers, including glioblastoma (GBM). In tumors with wild-type status, p53 function is frequently attenuated by alternate mechanisms including amplification and overexpression of it…