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Cited by 18Parasitic Infections and DiagnosticsMyxozoan Parasites in Aquatic SpeciesInfectious Diseases and Mycology

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Successful Treatment of Disseminated Anncaliia algerae Microsporidial Infection With Combination Fumagillin and Albendazole

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Boileau, Mélissa, Ferreira, José, Ahmad, Imran, Lavallée, Christian, Qvarnstrom, Yvonne, Dufresne, Simon F.·2016·Open Forum Infectious Diseases
DOI 10.1093/ofid/ofw158PMC PMC5047403
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Abstract

Anncaliia algerae myositis is a life-threatening, emerging microsporidiosis among immunocompromised hosts. We report a case of disseminated A algerae infection in a man previously treated with alemtuzumab. Due to failure of albendazole-based therapy, fumagillin was added as a novel approach to management, with a good clinical response and patient survival.

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Figure 1. Clinical and biological response to therapy and CD4 cell count. Creatine kinase (CK), high-sensitivity cardiac troponin T (hs-cTnT), body temperature (highest measure of each day, any body site) and CD4 cell count are shown according to time after diagnosis. Dashed lines represent the upper normal limit value for each parameter. Fumagillin treatment (20 mg 3 times daily) and maintenance (20 mg once daily) therapy periods are shown in full dark gray and checkered light gray, respectively. Albendazole was given concomitantly with fumagillin.
Figure 1. Clinical and biological response to therapy and CD4 cell count. Creatine kinase (CK), high-sensitivity cardiac troponin T (hs-cTnT), body temperature (highest measure of each day, any body site) and CD4 cell count are shown according to time after diagnosis. Dashed lines represent the upper normal limit value for each parameter. Fumagillin treatment (20 mg 3 times daily) and maintenance (20 mg once daily) therapy periods are shown in full dark gray and checkered light gray, respectively. Albendazole was given concomitantly with fumagillin.CC BY-NC-ND · PubMed Central

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Research works printed but not linked: 13

  1. Ramanan, 2014, Extraintestinal microsporidiosis, J Clin Microbiol, 52, 3839, 10.1128/JCM.00971-14 · DOI
  2. Watts, 2014, Anncaliia algerae microsporidial myositis, Emerg Infect Dis, 20, 185, 10.3201/eid2002.131126 · DOI
  3. Molina, 2002, Fumagillin treatment of intestinal microsporidiosis, N Engl J Med, 346, 1963, 10.1056/NEJMoa012924 · DOI
  4. Coyle, 2004, Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogen, N Engl J Med, 351, 42, 10.1056/NEJMoa032655 · DOI
  5. Field, 2012, Myositis due to the microsporidian Anncaliia (Brachiola) algerae in a lung transplant recipient, Transpl Infect Dis, 14, 169, 10.1111/j.1399-3062.2012.00724.x · DOI
  6. Cali, 2005, A review of the development of two types of human skeletal muscle infections from microsporidia associated with pathology in invertebrates and cold-blooded vertebrates, Folia Parasitol (Praha), 52, 51, 10.14411/fp.2005.007 · DOI
  7. Santiana, 2015, Analysis of the beta-tubulin gene and morphological changes of the microsporidium Anncaliia algerae both suggest albendazole sensitivity, J Eukaryot Microbiol, 62, 60, 10.1111/jeu.12160 · DOI
  8. Katznelson, 1952, Control of nosema disease of honeybees with fumagillin, Science, 115, 70, 10.1126/science.115.2977.70 · DOI
  9. Didier, 2006, Antimicrosporidial activities of fumagillin, TNP-470, ovalicin, and ovalicin derivatives in vitro and in vivo, Antimicrob Agents Chemother, 50, 2146, 10.1128/AAC.00020-06 · DOI
  10. Coyle, 1998, TNP-470 is an effective antimicrosporidial agent, J Infect Dis, 177, 515, 10.1086/517390 · DOI
  11. Beauvais, 1994, In vitro model to assess effect of antimicrobial agents on Encephalitozoon cuniculi, Antimicrob Agents Chemother, 38, 2440, 10.1128/AAC.38.10.2440 · DOI
  12. Alvarado, 2009, Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470, Mol Biochem Parasitol, 168, 158, 10.1016/j.molbiopara.2009.07.008 · DOI
  13. Zhang, 2005, Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis, Folia Parasitol (Praha), 52, 182, 10.14411/fp.2005.023 · DOI

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Metadata

Authors
Boileau, M., Ferreira, J., Ahmad, I., Lavallée, C., Qvarnstrom, Y., & Dufresne, S. F.
Affiliations
  • Departments of Hematology-Oncology
  • Pathology
  • Hôpital Maisonneuve-Rosemont (CA)
  • Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia
Corresponding author
Boileau, Mélissa
ORCID
Venue
Open Forum Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2016
Volume
3
Issue
3
Pages
ofw158-ofw158
ISSN
2328-8957 (ISSN-L)
DOI
10.1093/ofid/ofw158
PMC
PMC5047403
OpenAlex
W2504443420
Cited by
18
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 4 · 2019: 2 · 2018: 2 · 2017: 1
FWCI
1.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Open Forum Infectious Diseases (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • Centers for Disease Control and Prevention
  • Health Canada
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
  • Life Sciences › Immunology and Microbiology › Parasitology › Myxozoan Parasites in Aquatic Species
  • Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Mycology
Keywords
microsporidiosis, disseminated infection, fumagillin, albendazole, combination therapy, alemtuzumab, immunocompromised patients, myositis

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CoChat. (2026). Citation check: Successful Treatment of Disseminated Anncaliia algerae Microsporidial Infection With Combination Fumagillin and Albendazole. https://app.cochat.ai/papers/10.1093/ofid/ofw158
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Boileau, M., Ferreira, J., Ahmad, I., Lavallée, C., Qvarnstrom, Y., & Dufresne, S. F. (2016). Successful Treatment of Disseminated Anncaliia algerae Microsporidial Infection With Combination Fumagillin and Albendazole. Open Forum Infectious Diseases. https://doi.org/10.1093/ofid/ofw158