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Stomach Cancer
Abstract
Stomach cancer is the fifth most common incident cancer worldwide and the third leading cause of cancer death. Almost half of the world’s cases occur in Asia, with 42% in China alone. Although the incidence and mortality rates from stomach cancer are decreasing, the global disease burden remains high. Moreover, the absolute number of cases continues to rise because of population aging. Adenocarcinomas comprise over 90% of gastric malignancies. The adenocarcinomas are further classified according to anatomic location (cardia vs. non-cardia), histology (e.g., intestinal or diffuse, signet ring or non-signet ring) and most recently by molecular classification. Adenocarcinomas in the body and antrum of the stomach are usually caused by chronic infection with Helicobacter pylori (H. pylori); the incidence of these tumors is decreasing worldwide. Cardia tumors have epidemiological characteristics more similar to those of esophageal adenocarcinoma; the incidence of these tumors is increasing, particularly in high-income Western countries.
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“A dual etiology is implicated, with some cancers associated with excess body weight and gastroesophageal reflux disease, similar to the epidemiologic profile of esophageal adenocarcinoma.109”
From Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. (2024) · cites this paper as [109]
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Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024) · CA: a cancer journal for clinicians · doi:10.3322/caac.21834 · Cited by 27,064
Besaw, R. J., Smith, M. P., Zerillo, J. A., et al. (2019) · BMJ Case Reports · doi:10.1136/bcr-2019-232388 · Cited by 17
Wang, L., Xue, J., Wei, F., et al. (2021) · Human & Experimental Toxicology · doi:10.1177/0960327121997979 · Cited by 16
Jayasekara, H., MacInnis, R. J., Luján‐Barroso, L., Mayén, A., Cross, A. J., Wallner, B., Palli, D., Ricceri, F., Pala, V. M., Panico, S., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33504 · Cited by 15
Different trends in stomach and pancreatic cancer mortality rates
Aragonés, N., & Blázquez, D. P. (2024) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2024.10504/2024 · Cited by 4
Response to Editorial: Gastric and Pancreatic Cancer Trends in Spain
Domínguez, A. C., & Cayuela, L. (2024) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2024.10524/2024 · Cited by 1
Metadata
- Authors
- Martel, C. D., & Parsonnet, J.
- Venue
- Oxford Scholarship Online
- Publisher
- Oxford University Press
- Published
- 2017-12-21
- OpenAlex
- W4252325992
- Cited by
- 6
- References
- 0
- Citations by year
- 2024: 3 · 2021: 2 · 2019: 1
- FWCI
- 0.84
- Type
- book
- Language
- en
- Open access
- closed
- Locations
- Oxford University Press eBooks (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Tumor Research and Treatment
- Keywords
- gastric cancer, gastric adenocarcinoma, Helicobacter pylori infection, cardia tumors, molecular classification, incidence trends, mortality, population aging, esophageal adenocarcinoma
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