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Estimating the age of mutations using variation at linked markers
Abstract
Abstract We present a general method for estimating the dates of mutations using variation at linked microsatellite markers. Risch et al. ( 1995) take a similar approach to estimating the age of the mutation causing idiopathic torsion dystonia among Ashkenazic Jews, but they do not describe how to produce a confidence interval for the date. Here, we not only obtain a confidence interval for the date by assessing the degree of correlation among samples, but also describe how to use a Markov transition matrix approach to take full account of the complexities of the recombination process. Finally, we show how the method has been applied to a specific example: estimation of a date for a mutation that confers resistance to HIV-1 infection (Stephens et al. 1998).
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From an observed level of LD, allele age is estimated by solving for t.
“From an observed level of LD, allele age is estimate by solving for t (REFS 95,102).”
From Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. (2008) · cites this paper as [102]
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Linkage disequilibrium--understanding the evolutionary past and mapping the medical future.
Slatkin, M. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2361 · Cited by 1,614
Metadata
- Authors
- Reich, D. E., & Goldstein, D. B.
- Venue
- Microsatellites: Evolution and Applications
- Publisher
- Oxford University PressOxford
- Published
- 1999-06-10
- Pages
- 129-138
- OpenAlex
- W4388325203
- Cited by
- 29
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2018: 1 · 2017: 1 · 2014: 1
- FWCI
- 5.08
- Type
- book chapter
- Language
- en
- Open access
- closed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- mutation age estimation, recombination, transition matrix, confidence intervals, idiopathic torsion dystonia, HIV-1 resistance, linkage analysis
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