Mapping and cloning
Abstract
In order to identify zebrafish genes affected by mutations, both mutations and candidate genes are commonly placed on genome maps (Figure 1). Two types of maps are relevant for this approach: genetic maps, in which the probability of meiotic recombination between markers is used to determine their distance and construct the map; and radiation hybrid maps, in which breakage induced by radiation takes the place of recombination. Mutations can be placed only on genetic maps. This type of map is produced by scoring a large number of polymorphic markers on a panel of F2 fish from a reference cross. Two markers are close to each other if they give a similar pattern of alleles across the panel. Mutations are placed on the map indirectly, by scoring previously mapped markers on a panel of mutant.
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Rough mapping of F2 progeny against a reference panel of SSLP markers indicated that fls was located on linkage group (chromosome) 9 (LG9) with loose linkage to z20031 (61.3cR).
“Rough mapping of F2 progeny against a reference panel of SSLP markers [63] indicated that fls was located on linkage group (chromosome) 9 (LG9) with loose linkage to z20031 (61.3cR; Figure 3A).”
From Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates (2008) · cites this paper as [63]
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Harris, M. P., Rohner, N., Schwarz, H., Perathoner, S., Konstantinidis, P., & Nüsslein-Volhard, C. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000206 · Cited by 224 · see citing works
Hall, T. E., Bryson-Richardson, R. J., Berger, S., Jacoby, A. S., Cole, N. J., Hollway, G. E., Berger, J., & Currie, P. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700942104 · Cited by 178 · see citing works
- Authors
- Geisler, R.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- Corresponding author
- Geisler, Robert
- ORCID
- Geisler, Robert
- Venue
- Zebrafish
- Publisher
- Oxford University PressOxford
- Published
- 2002-09-19
- Pages
- 175-212
- OpenAlex
- W4388252632
- Cited by
- 49
- References
- 0
- Citations by year
- 2022: 1 · 2020: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 5.03
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Oxford University Press eBooks (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- gene mapping, radiation hybrid mapping, mutation mapping, candidate genes, meiotic recombination, polymorphic markers, gene cloning
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