Cited by 832Diabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, DietCancer Risks and Factors

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Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses’ Health Study

Carey, V. J., Walters, E. E., Colditz, G. A., Solomon, C. G., Willet, W. C., Rosner, B. A., Speizer, F. E., Manson, J. E.·1997·American Journal of Epidemiology

DOI 10.1093/oxfordjournals.aje.a009158

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Abstract

Obesity is an established risk factor for non-insulin-dependent diabetes mellitus (NIDDM). Anthropometric measures of overall and central obesity as predictors of NIDDM risk have not been as well studied, especially in women. Among 43,581 women enrolled in the Nurses' Health Study who in 1986 provided waist, hip, and weight information and who were initially free from diabetes and other major chronic diseases, NIDDM incidence was followed from 1986 to 1994. After adjustment for age, family history of diabetes, smoking, exercise, and several dietary factors, the relative risk of NIDDM for the 90th percentile of body mass index (BMI) (weight (kg)/height (m)2) (BMI = 29.9) versus the 10th percentile (BMI = 20.1) was 11.2 (95% confidence interval (CI) 7.9-15.9). Controlling for BMI and other potentially confounding factors, the relative risk for the 90th percentile of waist: hip ratio (WHR) (WHR = 0.86) versus the 10th percentile (WHR = 0.70) was 3.1 (95% CI 2.3-4.1), and the relative risk for the 90th percentile of waist circumference (36.2 inches or 92 cm) versus the 10th percentile (26.2 inches or 67 cm) was 5.1 (95% CI 2.9-8.9). BMI, WHR, and waist circumference are powerful independent predictors of NIDDM in US women. Measurement of BMI and waist circumference (with or without hip circumference) are potentially useful tools for clinicians in counseling patients regarding NIDDM risk and risk reduction.

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Authors: Carey, V. J., Walters, E. E., Colditz, G. A., Solomon, C. G., Willet, W. C., Rosner, B. A., Speizer, F. E., & Manson, J. E.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Carey, V. J.
ORCID: Carey, V. J.
Colditz, G. A.
Solomon, C. G.
Rosner, B. A.
Manson, J. E.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 1997-04-01
Volume: 145
Issue: 7
Pages: 614-619
ISSN: 0002-9262 (ISSN-L)
1476-6256
DOI: 10.1093/oxfordjournals.aje.a009158
OpenAlex: W2154904247
Cited by: 827
References: 0
Citations by year: 2026: 3 · 2025: 7 · 2024: 9 · 2023: 22 · 2022: 24 · 2021: 22 · 2020: 22 · 2019: 16 · 2018: 23 · 2017: 38 · 2016: 32 · 2015: 38 · 2014: 55 · 2013: 31 · 2012: 48
FWCI: 9.05
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA-40356)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 46798)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Keywords: type 2 diabetes, body fat distribution, abdominal obesity, waist circumference, waist-to-hip ratio, body mass index, obesity, women, diabetes risk factors, Nurses' Health Study
MeSH terms: Adult, Body Constitution, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Humans, Middle Aged, Obesity, Prospective Studies, Surveys and Questionnaires, Risk Factors, Time Factors, United States, Body Mass Index, Incidence, Multivariate Analysis, Age Distribution

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Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses’ Health Study

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