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IMPAIRED PULMONARY FUNCTION AS A RISK FACTOR FOR MORTALITY
Abstract
Prospective follow-up information obtained between 1976 and 1981 on mortality among 2539 individuals showed that pulmonary function impairment is a risk factor for short-term mortality, even when risk factors such as age, sex, and smoking are considered. Predicted risk curves for impaired individuals (those with forced expiratory volume in one second less than 68% of forced vital capacity) are consistently higher among all race-sex categories over all ages. Survival analysis using the proportional hazards model shows a steeper decline in estimated survival among individuals with poor pulmonary function compared to those with good pulmonary function, adjusted for age, race, and smoking effects. These observations are consistent with the concept that impairment of pulmonary function is a risk factor for morbidity and mortality from several nonrespiratory as well as respiratory diseases and that it acts by contributing to various pathogenic mechanisms in different organ systems.
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“Longitudinal studies have illustrated that pulmonary function impairment is a predictor for morbidity and mortality and may promote the development of multiple disease processes (1, 2).”
From Aging and Lung Disease (2020) · cites this paper as [2]
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Metadata
- Authors
- BEATY, T. H., COHEN, B. H., NEWILL, C. A., MENKERS, H. A., DIAMOND, E. L., & CHEN, C. J.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- BEATY, T. H.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1982-07
- Volume
- 116
- Issue
- 1
- Pages
- 102-113
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2097622753
- Cited by
- 149
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Social Sciences › Health › Health disparities and outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- respiratory dysfunction, mortality risk, FEV1, forced vital capacity, short-term mortality, survival analysis, smoking, race and sex differences, respiratory mortality
- MeSH terms
- Adult, Epidemiologic Methods, Female, Follow-Up Studies, Humans, Lung Diseases, Obstructive, Male, Maryland, Middle Aged, Mortality, Regression Analysis, Risk, Time Factors
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