The DOI matches its Crossref record.
ENDOGENOUS SEX HORMONE LEVELS IN OLDER ADULT MEN WITH DIABETES MELLITUS
Abstract
In a Southern California population-based cohort of 985 men aged 40-79 years in 1972-1974, 110 men with diabetes had significantly lower mean levels of endogenous plasma testosterone and sex hormone-binding globulin than did 875 nondiabetic men. Mean androstenedione, estrone, and estradiol levels did not differ significantly by diabetic status. The testosterone and sex hormone-binding globulin differences were reduced but not eliminated after adjustment for age and body mass index (weight (kg)/height (m)2). Twenty-one percent of diabetic men compared with 13% of nondiabetic men had testosterone levels below a categorically defined normal level of 3,500 pg/ml. Testosterone was inversely related to degree of glycemia in the whole cohort. Throughout the whole range of plasma glucose, there was a stepwise decrease in mean testosterone levels per categorical increase in fasting plasma glucose, apparent in both diabetics and nondiabetics. The clinical and physiologic implications of the reduced testosterone levels in diabetic men merit further investigation.
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“Furthermore, it has been reported that testosterone levels are lower in diabetic men compared with nondiabetic subjects (6 -9).”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [6]
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The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
“Both testosterone and SHBG tend to decrease in elderly men with diabetes mellitus (207).”
BackgroundKapoor, D., Goodwin, E., Channer, K. S., & Jones, T. H. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02166 · Cited by 791
Human prostate cancer risk factors
Bostwick, D. G., BURKE, H. B., Djakiew, D., Euling, S. Y., Ho, S., Landolph, J. R., MORRISON, H. I., Sonawane, B. R., Shifflett, T., Waters, D. J., et al. (2004) · Cancer · doi:10.1002/cncr.20408 · Cited by 675
Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes
Dhindsa, S., Prabhakar, S., Sethi, M., Bandyopadhyay, A., Chaudhuri, A., & Dandona, P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0804 · Cited by 631
Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes
Kapoor, D., Aldred, H., Clark, S., Channer, K. S., & Jones, T. H. (2007) · Diabetes Care · doi:10.2337/dc06-1426 · Cited by 493
Metadata
- Authors
- BARRETT-CONNOR, E., KHAW, K.-T., & YEN, S. S. C.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- BARRETT-CONNOR, E.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1990-11
- Volume
- 132
- Issue
- 5
- Pages
- 895-901
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W1957056004
- Cited by
- 217
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 7
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl034591-02, 5r01am031801-03)
- National Heart, Lung, and Blood Institute (HL 34591, HV-1-2160-L)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, testosterone, sex hormone-binding globulin, androstenedione, estrone, estradiol, older men, fasting blood glucose, glycemia, body mass index, hypogonadism
- MeSH terms
- Adult, Aged, Blood Glucose, Blood Pressure, Cholesterol, Diabetes Mellitus, Humans, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Body Mass Index
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