CoChat
Sign Up
Cited by 121Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicalsPesticide Exposure and Toxicity

The DOI matches its Crossref record.

Total Serum Testosterone and Gonadotropins in Workers Exposed to Dioxin

Egeland, Grace M., Sweeney, Marie H., Fingerhut, Marilyn A., Wille, Kathleen K., Schnorr, Teresa M., Halperin, William E.·1994·American Journal of Epidemiology
DOI 10.1093/oxfordjournals.aje.a116994
Open this paper in CoChat — free account

Abstract

Human reproductive endocrine data may be an important source of epidemiologic information in regard to the toxic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). The association of serum dioxin with total serum testosterone, luteinizing hormone, and follicle-stimulating hormone was examined in 248 chemical production workers from New Jersey and Missouri plants and 231 nonexposed neighborhood referents who participated in a medical evaluation in 1987. In linear regression analyses, current serum dioxin was positively and significantly related to luteinizing hormone and follicle-stimulating hormone and inversely related to total testosterone after adjustment for potential confounders (p 28 IU/liter), high follicle-stimulating hormone (> 31 IU/liter), and low testosterone (< 10.4 nmol/liter) by serum dioxin quartiles. There was a greater prevalence of high luteinizing hormone among workers in the second (odds ratio (OR) = 1.9, 95% confidence interval (CI) 0.7-5.5), third (OR = 2.5, 95% CI 0.9-7.3), and fourth (OR = 1.9, 95% CI 0.7-5.0) quartiles of serum dioxin compared with referents. For follicle-stimulating hormone, the authors observed a greater prevalence of high follicle-stimulating hormone among workers in the fourth quartile (OR = 2.0, 95% CI 0.7-5.6) compared with referents. Similarly, the prevalence of low testosterone was two to four times greater among workers in the second (OR = 3.9, 95% CI 1.3-11.3), third (OR = 2.7, 95% CI 0.9-8.2), and fourth quartiles…

Overview

Integrity signals

Registry

Crossref · 10.1093/oxfordjournals.aje.a116994

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Items 101–121 of 121

Related

See all

Metadata

Authors
Egeland, G. M., Sweeney, M. H., Fingerhut, M. A., Wille, K. K., Schnorr, T. M., & Halperin, W. E.
Affiliations
National Institute for Occupational Safety and Health (US)
Corresponding author
Sweeney, Marie H.
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
1994-02-01
Volume
139
Issue
3
Pages
272-281
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/oxfordjournals.aje.a116994
OpenAlex
W4317525784
Cited by
120
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 5 · 2012: 3
FWCI
6.12
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Keywords
dioxin exposure, 2,3,7,8-tetrachlorodibenzo-p-dioxin, serum testosterone, luteinizing hormone, follicle-stimulating hormone, gonadotropins, occupational exposure, hypothalamic-pituitary-gonadal axis, reproductive toxicity, androgen deficiency
MeSH terms
Adult, Aged, Aged, 80 and over, Dioxins, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Male, Middle Aged, Missouri, New Jersey, Population Surveillance, Reproduction, Testosterone, Confounding Factors, Epidemiologic, Prevalence, Confidence Intervals, Linear Models, Logistic Models, Odds Ratio, Case-Control Studies, Occupational Exposure, Matched-Pair Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review