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THE PROGNOSIS OF A POSITIVE TUBERCULIN REACTION IN CHILDHOOD AND ADOLESCENCE
Abstract
In the course of a controlled trial of bacillus of Calmette and Guerin vaccination among Puerto Rican children in 1949–1951, 82, 269 reactors to 1 or 10 tuberculin units of purified protein derivative were identified. During the 18 to 20 years after initial testing, 1400 cases of tuberculosis were identified among these tuberculin reactors. The major risk factor was age. Children under four years of age had the highest tuberculosis rates and the most serious disease. A secondary peak of incidence was observed at about 20 years of age. At all ages, children with the strongest sensitivity to tuberculin had the highest rates of subsequent tuberculosis. The risk for females and for urban residents was slightly greater than for males and rural residents. Essentially no difference in tuberculosis risk was found between white and black reactors. Because the risk of tuberculosis among infected persons appears to persist for a lifetime, the need for preventive treatment is highly dependent on age, and to a considerable but lesser extent on degree of tuberculin sensitivity.
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Citations
Cited by
Lewinsohn, D. M., Leonard, M. K., LoBue, P. A., Cohn, D. L., Daley, C. L., Desmond, E., Keane, J., Lewinsohn, D. A., Loeffler, A. M., Mazurek, G. H., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/ciw694 · Cited by 992
“Young children are at increased risk of developing TB following infection and more likely to develop severe disease than older children and adults [99, 100].”
BackgroundNonreplicating Persistence of Mycobacterium Tuberculosis
Wayne, L. G., & Sohaskey, C. D. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.139 · Cited by 807
Frieden, T. R., Sterling, T. R., Munsiff, S. S., Watt, C. J., & Dye, C. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14333-4 · Cited by 689
Wolf, A. J., Desvignes, L., Linas, B., Banaiee, N., Tamura, T., Takatsu, K., & Ernst, J. D. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071367 · Cited by 580
VYNNYCKY, E., & FINE, P. E. M. (1997) · Epidemiology and Infection · doi:10.1017/s0950268897007917 · Cited by 555
Metadata
- Authors
- COMSTOCK, G. W., LIVESAY, V. T., & WOOLPERT, S. F.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 1974-02
- Volume
- 99
- Issue
- 2
- Pages
- 131-138
- ISSN
- 0002-9262 (ISSN-L)
- 1476-6256
- OpenAlex
- W2212212330
- Cited by
- 698
- References
- 0
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE PROGNOSIS OF A POSITIVE TUBERCULIN REACTION IN CHILDHOOD AND ADOLESCENCE. https://app.cochat.ai/papers/10.1093/oxfordjournals.aje.a121593
- The paper
- COMSTOCK, G. W., LIVESAY, V. T., & WOOLPERT, S. F. (1974). THE PROGNOSIS OF A POSITIVE TUBERCULIN REACTION IN CHILDHOOD AND ADOLESCENCE. American Journal of Epidemiology. https://doi.org/10.1093/oxfordjournals.aje.a121593
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
