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Free radicals in biological systems—a review orientated to inflammatory processes
Abstract
Free radicals are chemical species with one or more unpaired electrons in their outer orbital. Their production is essential to normal metabolism but they are theoretically destructive unless tightly controlled. We review the chemistry of free radical production and the intra/extracellular defence systems that limit their toxicity. Particular reference is made to biochemical processes which we believe are relevant to maintaining an inflammatory reaction. As a clinical illustration we describe mechanisms pertinent to the perpetuation of the chronic inflammation of rheumatoid synovitis.
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Cited by
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Ebbeling, C. B., & Clarkson, P. M. (1989) · Sports Medicine · doi:10.2165/00007256-198907040-00001 · Cited by 599
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Vanadium compounds in medicine
Pessoa, J. C., Etcheverry, S., & Gambino, D. (2015) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2014.12.002 · Cited by 561
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Metadata
- Authors
- Blake, D. R., Allen, R. E., & Lunec, J.
- Venue
- British Medical Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1987-04
- Volume
- 43
- Issue
- 2
- Pages
- 371-385
- ISSN
- 0007-1420 (ISSN-L)
- 1471-8391
- OpenAlex
- W2231534578
- Cited by
- 232
- References
- 0
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blake, D. R., Allen, R. E., & Lunec, J. (1987). Free radicals in biological systems—a review orientated to inflammatory processes. British Medical Bulletin. https://doi.org/10.1093/oxfordjournals.bmb.a072188
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
