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Cited by 174

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BCG vaccination against tuberculosis and leprosy

Fine, P E M·1988·British Medical Bulletin

Abstract

This paper reviews the origin, use, protective efficacy and public health impact of BCG vaccines. The problem of evaluating their efficacy is discussed with reference to various hypotheses which have been proposed to explain the divergent estimates obtained in studies carried out in different areas of the world. It is concluded that, despite the apparent variation in protective efficacy, the extensive use of BCG vaccines (more than three billion doses worldwide in four decades) means that they have had a substantial impact on tuberculosis and leprosy. The problem of explaining BCG's varying protection remains unsolved but of great importance, because of the scale of BCG use and current effort to develop improved vaccines against tuberculosis and leprosy.

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Metadata

Authors
Fine, P. E. M.
Venue
British Medical Bulletin
Published
1988
Volume
44
Issue
3
Pages
691-703
ISSN
  • 0007-1420 (ISSN-L)
  • 1471-8391
OpenAlex
W1888535285
Cited by
174
References
0
FWCI
7.05
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: BCG vaccination against tuberculosis and leprosy. https://app.cochat.ai/papers/10.1093/oxfordjournals.bmb.a072277
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Fine, P. E. M. (1988). BCG vaccination against tuberculosis and leprosy. British Medical Bulletin. https://doi.org/10.1093/oxfordjournals.bmb.a072277

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.