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Uterine hyperperistalsis and dysperistalsis as dysfunctions of the mechanism of rapid sperm transport in patients with endometriosis and infertility
Abstract
Women suffering from infertility in association with mostly mild endometriosis were subjected to vaginal sonography of uterine peristalsis during the menstrual period, the early, mid- and late follicular phases, and the mid-luteal phase of the menstrual cycle. The data obtained were compared with those of healthy controls. Women with endometriosis displayed a marked uterine hyperperistalsis that differed significantly from the peristalsis of the controls during the early and mid-follicular and mid-luteal phases. During the late follicular phase of the cycle, uterine peristalsis in women with endometriosis became dysperistaltic, arrhythmic and convulsive in character, while in controls peristalsis continued to show long and regular cervico-fundal contractions. Hysterosalpingoscintigraphy during the early, mid- and late follicular phases revealed that hyperperistalsis in the early and mid-follicular phases of patients with endometriosis resulted in a dramatic increase in the transport of inert particles from the vaginal depot, through the uterus into the tubes and also into the peritoneal cavity. During the late follicular phase of the cycle, the dysperistalsis observed in women with endometriosis resulted in a dramatic reduction of uterine transport capacity in comparison with the healthy controls. We consider uterine hyperperistalsis to be the mechanical cause of endometriosis rather than retrograde menstruation. Dysperistalsis in the late follicular phase of patients with endometriosis may compromise rapid sperm transport. Uterine hyperperistalsis and dysperistalsis are considered to be responsible for both reduced fertility and the development of endometriosis.
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In the citing paper
“Third, uterine hyperperistalsis/dysperistalsis may be a result of archimetral hyperestrogenism [38,47].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [38]
In the citing paper
“In a nutshell, they showed that uterine peristalsis is critical for sperm transport, and women with endometriosis exhibit hyperperistalsis and dysperistalsis [38,39,40,41].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [38]
In the citing paper
“It was suggested that this uterine dysfunction in women with endometriosis and adenomyosis is a result of archimetral hyperestrogenism [3, 4, 29, 33].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [29]
In the citing paper
“The uterine function of rapid and directed sperm transport into the ‘dominant tube’ is dysfunctional in women with endometriosis and is characterized by hyper- and dysperistalsis [27–32].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [29]
In the citing paper
“The intensity of uterine peristaltic activity in women with endometriosis resembles that of women during controlled ovarian hyperstimulation although the peripheral estradiol levels are within the normal range [4, 29, 44].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [29]
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Items 101–200 of 307
Kinematics of the Uterus: Cine Mode MR Imaging
Fujiwara, T., Togashi, K., Yamaoka, T., Nakai, A., Kido, A., Nishio, S., Yamamoto, T., Kitagaki, H., & Fujii, S. (2004) · Radiographics · doi:10.1148/rg.e19 · Cited by 48
How to Understand the Complexity of Endometriosis-Related Pain
Chiàntera, V., Abesadze, E., & Mechsner, S. (2017) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000271 · Cited by 49
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“As an outlook for further investigations, it would be interesting to perform IUP recordings in patients with endometriosis, as endometriosis and adenomyosis uteri can be regarded as a unique disease the dislocation of the basal endometrium (19), which is linked with hyperand dysperistalsis and impeded transport functi…”
BackgroundGandini, S., Lazzeroni, M., Peccatori, F. A., Bendinelli, B., Saieva, C., Palli, D., Masala, G., & Caini, S. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.12.009 · Cited by 46
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Nakai, A., Togashi, K., Kosaka, K., Kido, A., Hiraga, A., Fujiwara, T., Koyama, T., & Fujii, S. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20140 · Cited by 45
Use of laparoscopic cytoreductive surgery to treat infertile women with localized adenomyosis
Wang, C., Yuen, L., Chang, S., et al. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.12.066 · Cited by 44
Mechanisms Underlying Adenomyosis-Related Fibrogenesis
Kobayashi, H., Kishi, Y., & Matsubara, S. (2019) · Gynecologic and Obstetric Investigation · doi:10.1159/000502822 · Cited by 44
George, A. F., Jang, K. S., Nyegaard, M., Neidleman, J. A., Spitzer, T., Xie, G., Chen, J. C., Herzig, E., Laustsen, A., de Menezes, E. G. M., et al. (2020) · Human Reproduction · doi:10.1093/humrep/deaa015 · Cited by 42
“For SP to induce decidualization of the endometrium in vivo, semen and SP components must reach the upper FRT, which may occur through peristalsis (Egli et al., 1961; Leyendecker et al., 1996; Kunz et al., 1997; Wildt et al., 1998; Barnhart et al., 2001).”
BackgroundOxytocin – a stimulator of directed sperm transport in humans
Kunz, G., Beil, D., Huppert, P. E., & LEYENDECKER, G. (2007) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60761-4 · Cited by 42
“…and pathophysiological conditions (Itturalde and Venter, 1981; Birnholz, 1984; Lyons et al., 1991; Steck et al., 1991; Kunz et al., 1996, 1998b; Leyendecker et al., 1996; Fanchin et al., 1998, 2001; Wildt et al., 1998; Bulletti et al., 2000; de Ziegler et al., 2001; Van Gestel et al., 2003;…”
BackgroundMethodResultInfluentialSelf-citationCellular Origins of Endometriosis: Towards Novel Diagnostics and Therapeutics
Filby, C. E., Rombauts, L. J. F., Montgomery, G. W., Giudice, L. C., & Gargett, C. E. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1713429 · Cited by 40
Ultrasound evaluation of the uterine zonal anatomy during in-vitro fertilization and embryo transfer
Lesny, P., Killick, S. R., Tetlow, R. L., Manton, D. J., Robinson, J., & Maguiness, S. D. (1999) · Human Reproduction · doi:10.1093/humrep/14.6.1593 · Cited by 40
Endometriosis and Adenomyosis: From Pathogenesis to Follow-Up
Martire, F. G., Costantini, E., d’Abate, C., Schettini, G., Sorrenti, G., Centini, G., Zupi, E., & Lazzeri, L. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47050298 · Cited by 46
“The formation of an adenomyosis focus results in platelet aggregation and a hypoxic condition, which stimulates the production of inflammatory cytokines, prostaglandins, and an increase in local estrogen synthesis [131].”
Clinical outcomes of infertility treatment for women with adenomyosis in Japan
Tamura, H., Kishi, H., Kitade, M., Asai‐Sato, M., Tanaka, A., Murakami, T., Minegishi, T., & Sugino, N. (2017) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12036 · Cited by 41
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Archimetrosis: the evolution of a disease and its extant presentation
LEYENDECKER, G., Wildt, L., Laschke, M. W., & Mall, G. (2022) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06597-y · Cited by 38
“In women with endometriosis/adenomyosis (archimetrosis), the mean number of contraction waves is doubled and the intrauterine pressure is increased [1, 8, 83].”
BackgroundInfluentialSelf-citationZhou, C., Zhang, T., Liu, F., Zhou, J., Ni, X., Huo, R., & Shi, Z. (2015) · Molecular BioSystems · doi:10.1039/c5mb00733j · Cited by 37
Seminal plasma—Immunomodulatory potential in men with normal and abnormal sperm count
von Wolff, M., Nowak, O., Pinheiro, R. M., et al. (2007) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2007.01.009 · Cited by 36
“It was therefore speculated that seminal plasma ascends through the cervix by subendometrial and myometrial peristaltic waves [11,12], where it modulates endometrial receptivity.”
BackgroundAdenomyosis: New Knowledge is Generating New Treatment Strategies
Benagiano, G., Brosens, I. A., & Carrara, S. (2009) · Women s Health · doi:10.2217/whe.09.7 · Cited by 35
Control and function of uterine peristalsis during the human luteal phase
Kunz, G., Beil, D., Huppert, P. E., & LEYENDECKER, G. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60641-4 · Cited by 38
“The reanalysis of the VSUP during the follicular phases of the menstrual cycles of healthy women and of women with endometriosis confi rmed the previously published results (Kunz et al., 1996, 1997; Leyendecker et al., 1996).”
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Ayoubi, J.-M., Fanchin, R. R. F., Kaddouz, D., et al. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01998-7 · Cited by 34
Implantation markers and endometriosis
Bulletti, C., Flamigni, C., & de Ziegler, D. (2005) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61142-x · Cited by 31
“, 2000), its pathological role in infertility (Lyons et al., 1991; Ijland et al., 1996; Kunz et al., 1996; Leyendecker et al., 1996; Bulletti et al., 2001, 2002), as well its role in embryo implantation (Fanchin et al.”
BackgroundSalmeri, N., Stefano, G. D., Viganò, P., Stratton, P., Somigliana, E., & Vercellini, P. (2024) · Fertility and Sterility · doi:10.1016/j.fertnstert.2024.07.026 · Cited by 35
How to Evaluate Adenomyosis in Patients Affected by Endometriosis?
Donato, N. D., & Seracchioli, R. (2014) · Minimally Invasive Surgery · doi:10.1155/2014/507230 · Cited by 32
Adenomyosis and female fertility: A critical review of the evidence
Sunkara, S. K., & Khan, K. S. (2012) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2011.624208 · Cited by 30
“Th e rationale for the association between adenomyosis and infertility is the impairment of the uterine mechanism of sperm transport, possibly due to the destruction of the normal myometrial architecture (Leyendecker et al. 1996).”
BackgroundHabiba, M. A., Benagiano, G., & Guo, S. (2023) · Biomolecules · doi:10.3390/biom13060975 · Cited by 31
“This casts doubts on its relevance to basal endometrial breakdown (which is referred to as the syndrome of dislocated basal endometrium) and its subsequent implantation [62].”
BackgroundInfluentialYi, K. W., Kim, S. H., Ihm, H. J., Oh, Y. S., Chae, H. D., Kim, C., & Kang, B. M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.12.124 · Cited by 29
Laparoscopic assisted adenomyomectomy using double flap method
Kim, J.-K., Shin, C. S., Ko, Y. B., et al. (2014) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2014.57.2.128 · Cited by 29
“In addition, it sometimes leads to infertility [3,4] and can become a cause of pregnancy-related complications.”
BackgroundAdenomyosis and its impact on women fertility.
Garavaglia, E., Serafini, A., Inversetti, A., Stefano, F., Tandoi, I., Corti, L., & Candiani, M. (2015) · PubMed Central · Cited by 32
Characteristics of uterine peristalsis in spontaneous and induced cycles
Eytan, O., Halevi, I., Har-Toov, J., Wolman, I., Elad, D., & Jaffa, A. J. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01926-4 · Cited by 29
Sammali, F., Kuijsters, N. P. M., Schoot, B. C., Mischi, M., & Rabotti, C. (2018) · Reproductive Sciences · doi:10.1177/1933719118768700 · Cited by 29
Naem, A., Andrikos, A., Constantin, A., Khamou, M., Andrikos, D., Laganà, A., De Wilde, R., & Krentel, H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206455 · Cited by 28
“Although patients with endometriosis were re-ported to have abnormal uterine peristalsis with longer and heavier menstrual cycles [34,35], we did not notice abnormal menstrual patterns in our cohort.”
BackgroundLaterality and asymmetry of endometriotic lesions
Guo, S., Wang, Y., Liu, X., & Olive, D. L. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.02.043 · Cited by 27
The human periconceptional maternal-embryonic space in health and disease
Moreno, I., Capalbo, A., Mas, A., Garrido‐Gómez, T., Rosón, B., Poli, M., Dimitriadis, E., Santamaría, X., Vilella, F., & Simón, C. (2023) · Physiological Reviews · doi:10.1152/physrev.00050.2021 · Cited by 32
Genazzani, A. R. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.709682 · Cited by 26
Impairment of Uterine Contractility Is Associated with Unexplained Infertility
Hunt, S., Abdallah, K. S., Ng, E. H. Y., Rombauts, L. J. F., Vollenhoven, B. J., & Mol, B. W. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716409 · Cited by 26
Mahdavinezhad, F., Gharaei, R., Farmani, A. R., Hashemi, F., Kouhestani, M., & Amidi, F. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00520-7 · Cited by 27
“Adenomyosis may change the normal peristaltic contractions of the uterus by altering the structure and function of the myometrium, and, thereby, the rapid and directed sperm transfer gets disrupted [100].”
BackgroundContractile reactivity of human myometrium in isolated non-pregnant uteri
Richter, O. N., Bartz, C., Dowaji, J., Kupka, M. S., REINSBERG, J., Ulrich, U. A., & Rath, W. H. (2005) · Human Reproduction · doi:10.1093/humrep/dei295 · Cited by 26
“…humans for questions on the field of uterine hyperperistalsis in connection with dysmenorrhoea and endometriosis (Åkerlund et al., 1995; Åkerlund, 2002; Bossmar et al., 1995; Ijland et al., 1998; Kunz et al., 1998; Leyendecker et al., 1996, 2004; Kunz and Leyendecker, 2002; de Gestel et al., 2003).”
BackgroundRevisiting the wandering womb: Oxytocin in endometriosis and bipolar disorder
Dinsdale, N. L., & Crespi, B. J. (2017) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.09.005 · Cited by 27
“…uterine activity: in healthy women, elevated uterine peristalsis prior to ovulation promotes rapid sperm transport and reduced uterine peristalsis after ovulation supports conception and implantation (IJland et al., 1997; Leyendecker et al., 1996; Kunz and Leyendecker, 2002; Kissler et al., 2007).”
BackgroundInfluentialKido, A., Togashi, K., Hatayama, H., Nakayama, T., Yamamoto, A., Kataoka, M., & Tulandi, T. (2009) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34278-5 · Cited by 25
Friedler, S., Ben‐Ami, I., Gidoni, Y., et al. (2013) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-013-0033-y · Cited by 24
Emerging drugs for endometriosis
Guo, S. (2008) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210802548360 · Cited by 25
“Dysperistalsis in the late follicular phase may compromise sperm transport, consequently impairing fertility [81] .”
BackgroundCarvalho, L. F. P., Rossener, R., Azeem, A., Malvezzi, H., Abrão, M. S., & Agarwal, A. K. (2013) · PubMed · Cited by 25
Junctional Zone on Magnetic Resonance Imaging: Continuous Changes on Ultrafast Images
Nakai, A., Togashi, K., Ueda, H., Yamaoka, T., Fujii, S., & Konishi, J. (2001) · Journal of women's imaging · doi:10.1097/00130747-200108000-00002 · Cited by 24
A semiautomated technique for evaluation of uterine peristalsis
Kido, A., Nishiura, M., Togashi, K., Nakai, A., Fujiwara, T., Kataoka, M. L., Koyama, T., Fujii, S., & Asada, N. (2005) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20258 · Cited by 23
“If we consider that one of the important functions of the uterus in the periovulatory phase is sperm transport in the cervico-fundal direction, which has been shown using isotopes, it is natural for the uterus to have a peristaltic pump in the cervico-fundal direction in the periovulatory phase (3,24,25).”
MethodWang, S., Duan, H., Zhang, Y., & Sun, F. (2015) · Reproductive Sciences · doi:10.1177/1933719115602764 · Cited by 23
“Women with endometriosis and ADS showed a significant increase in uterine peristaltic activity compared to women free of disease.(28) During the PP, the frequency of peristaltic waves is doubled compared to normal.”
BackgroundResultEinspanier, A. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.5.634 · Cited by 22
Wu, H., Tsai, T.-C., Liu, S.-M., Pai, A. H.-Y., & Chen, L.-H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168937 · Cited by 21
“An increasing number of studies have reported the impact of adenomyosis features on successful pregnancy outcomes after fertility treatment, including the extent or severity of adenomyosis lesions, based on images and clinical presentation.”
BackgroundComplex endometrial wave-patterns in IVF
van Gestel, I., IJland, M. M., Evers, J. L. H., & Hoogland, H. J. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.050 · Cited by 20
Do Endometrial Movements Affect The Achievement of Pregnancy during Intrauterine Insemination?
Kim, A., Lee, J. Y., Ji, Y. I., Lee, H., Lee, E. S., Kim, H. Y., & Oh, Y. L. (2015) · Europe PMC (PubMed Central) · doi:10.22074/ijfs.2015.4180 · Cited by 20
“As a complex reproductive organ, the uterus plays an active role in the early stages of pregnancy by providing a site for implantation and promoting the transport of spermatozoa (1-3).”
BackgroundA Modified Hai–Murphy Model of Uterine Smooth Muscle Contraction
Maggio, C. D., Jennings, S. R., Robichaux, J. L., Stapor, P. C., & Hyman, J. M. (2011) · Bulletin of Mathematical Biology · doi:10.1007/s11538-011-9681-1 · Cited by 19
“Disruption of the normal frequency, strength, and direction of uterine contractions is associated with a number of female reproductive pathologies, including endometriosis and adenomyosis (Leyendecker et al. 1996), nonimplantation of fertilized embryos during the receptive phase (Yaniv et al.”
BackgroundUterine anatomy and function on cine magnetic resonance imaging
Kido, A., & Togashi, K. (2016) · Reproductive Medicine and Biology · doi:10.1007/s12522-016-0235-y · Cited by 19
“reported hyperfrequent peristalsis in patients with endometriosis compared to control subjects in every menstrual phase based on TVUS findings [56].”
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Uterine peristalsis in women affected by adenomyosis: A step towards functional assessment
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Cine-MRI for Quantifying Uterine Peristalsis: A Systematic Review and Meta-Analysis
Vidal, A., Bora, C., von Holzen, J., Gulz, M., Obmann, V., Pape, J., Karrer, T., Yilmaz, G., & von Wolff, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14031021 · Cited by 13
“Uterine contractility is abnormal in endometriosis, which may facilitate its development through retrograde menstruation [3,41].”
InfluentialOptimized approach to cine MRI of uterine peristalsis
Liu, S., Zhang, Q., Yin, C., Liu, S., Chan, Q., Chen, W., He, J., & Zhu, B. (2016) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25303 · Cited by 17
Fertility-related considerations in endometriosis
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Vidal, À., Trejos, V., Pape, J., Karrer, T., Yılmaz, G., & von Wolff, M. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01380-5 · Cited by 18
The role of cine MR imaging in the assessment of uterine function
Soares, D. M., Werner, H., Bittencourt, L. K., Lopes, F. P. P. L., & Oliveira, M. A. P. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-019-05222-9 · Cited by 15
Qu, M., Lü, P., Bellve, K. D., Lifshitz, L. M., & ZhuGe, R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.744745 · Cited by 15
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Kuijsters, N. P. M., Sammali, F., Rabotti, C., Huang, Y., Mischi, M., & Schoot, B. C. (2019) · Journal of Ultrasound · doi:10.1007/s40477-018-00356-z · Cited by 16
Investigation of uterine peristalsis diurnal variation
Kido, A., Togashi, K., Nakai, A., Kataoka, M., Fujiwara, T., Kataoka, M. L., Fujimoto, R., Koyama, T., & Fujii, S. (2006) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2006.06.002 · Cited by 15
“For example, dysfunctional peristalsis observed in women with endometriosis results in reduced sperm transport compared with healthy controls during the follicular phase of the menstrual cycle [16].”
BackgroundSeminal Plasma Promotes Lesion Development in a Xenograft Model of Endometriosis
McGuane, J. T., Watson, K. M., Zhang, J., Johan, M. Z., Wang, Z., Kuo, G., Sharkey, D. J., Robertson, S. A., & Hull, M. L. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.01.010 · Cited by 14
“physiological possibility, and several studies have demonstrated that technetium-labeled albumin macrospheres placed at the external os of the cervix reach the tubes within 1 minute as a result of subendometrial and myometrial peristaltic activity.(35,36) Uterine contraction induced bymenstruation(34) and coitus may i…”
Background3D bioprinting technology innovation in female reproductive system
Chen, S., Wang, T., Chen, J., Sui, M., Wang, L., Zhao, X., Sun, J., & Lu, Y. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101551 · Cited by 13
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Determination of velocity of tubar transport with dynamic hysterosalpingoscintigraphy
Schmiedehausen, K., KAT, S., ALBERT, N., Platsch, G., Wildt, L., & Kuwert, T. (2003) · Nuclear Medicine Communications · doi:10.1097/01.mnm.0000084577.51410.c4 · Cited by 13
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Endometriosis: The elusive epiphenomenon
Quinn, M. J. (2009) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610903082484 · Cited by 12
“Dyspolar uterine activity causes retrograde menstruation that may contribute to dysmenorrhoea and subfertility (Leyendecker et al. 1996).”
BackgroundFoo, J. Y. A., & Lim, C. S. (2008) · Zygote · doi:10.1017/s0967199408004899 · Cited by 12
“Moreover, cervical mucus poses as a greater barrier to abnormal sperm that cannot swim properly or for those that have a poor hydrodynamic profile than it does to morphologically normal and vigorously motile sperm (Leyendecker et al., 1996, Katz et al., 1997).”
BackgroundParis, K., & Aris, A. (2010) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2010.08.030 · Cited by 13
Bricou, A., Borghese, B., Batt, R. E., Piketty, M., de Ziegler, D., & Chapron, C. (2009) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2008.12.009 · Cited by 12
Wing, D. A., Goharkhay, N., Felix, J. C., et al. (2006) · Gynecologic and Obstetric Investigation · doi:10.1159/000093588 · Cited by 11
Huang, J., Duan, H., Wang, S., & Wang, Y. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11976 · Cited by 11
Assisted reproduction technologies
Vatja, G., Callesen, H., Boe-Hansen, G. B., Hall, V. J., & Hyttle, P. (2010) · Cited by 11
A bird-eye view of diaphragmatic endometriosis: current practices and future perspectives
Naem, A., Roman, H., Martin, D. C., & Krentel, H. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1505399 · Cited by 16
Epithelial-to-mesenchymal transition in the development of adenomyosis
Huang, B., Tsai, H., Wang, P., Twu, N.-F., Yen, M., & Chen, Y. (2015) · Gynecology and Minimally Invasive Therapy · doi:10.1016/j.gmit.2015.05.002 · Cited by 10
Coexistence of endometriosis and uterine septum in patients with abortion or infertility
Demir, B., Dilbaz, B., Karadağ, B., Duraker, R., Akkurt, M. Ö., Koçak, M., & Göktolga, Ü. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01581.x · Cited by 10
“The possible explanation of the increased rate of endometriosis in patients with a uterine septum is an increased risk of retrograde menstruation and uterine dysperistalsis.(27,28) The increased risk of retrograde menstruation may be associated with obstructive müllerian anomalies; however, there are conflicting repor…”
BackgroundReproductive disorders affecting fertility in endometriosis
Brosens, I. A., Campo, R., & Gordts, S. (2002) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(12)60119-9 · Cited by 10
Steroid hormone-dependent myometrial zonal differentiation in the non-pregnant human uterus
Brosens, J. J., de Souza, N. M., & Barker, F. G. (1998) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(98)00198-5 · Cited by 9
The Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis
Grigoriadis, G., Roman, H., Gkrozou, F., & Daniilidis, A. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13164817 · Cited by 10
“Furthermore, Leyendecker et al. demonstrated that women with MME have uterine dysperistalsis during the late follicular phase which may compromise rapid sperm transport [30], although co-existent adenomyosis may be of greater importance in this context [31].”
BackgroundThe Impact of Laparoscopic Surgery on Fertility Outcomes in Patients with Minimal/Mild Endometriosis
Grigoriadis, G., & Daniilidis, A. (2024) · doi:10.20944/preprints202407.0446.v1 · Cited by 10
de Boer, A., Rees, C. O., Mischi, M., van Vliet, H. A. A. M., Huirne, J. A. F., & Schoot, B. C. (2023) · Journal of Endometriosis and Uterine Disorders · doi:10.1016/j.jeud.2023.100038 · Cited by 9
Evolutionäre Aspekte in der Pathogenese und Pathophysiologie von Adenomyose und Endometriose
LEYENDECKER, G., & Wildt, L. (2019) · Journal für Gynäkologische Endokrinologie/Österreich · doi:10.1007/s41974-019-00112-z · Cited by 9
Self-citationAscension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection
Callan, T., Woodcock, S., & Huston, W. M. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009365 · Cited by 8
“However, women with dysfunctions of the peristaltic mechanisms, such as hyperperistalsis, may experience peristaltic activity at three times the rate of women without these dysfunctions [28].”
BackgroundSoares, D. M., Bittencourt, L. K., Lopes, F. P. P. L., & Oliveira, M. A. P. (2023) · Radiologia Brasileira · doi:10.1590/0100-3984.2022.0069 · Cited by 8
“It has been suggested that dysfunction of the physiological mechanism of retrograde uterine peristaltic activity is implicated in the development of endometriosis((6,10,18,19)), as well as that changes in peristaltic activity and endometriosis both contribute to infertility.”
BackgroundMethodResultInfluentialEndometriose im Intestinaltrakt
Keckstein, J. (2017) · coloproctology · doi:10.1007/s00053-017-0144-5 · Cited by 8
LEYENDECKER, G., Kunz, G., Noe, M., Herbertz, M., Beil, D., Huppert, P. E., & Mall, G. (1999) · Reproduktionsmedizin · doi:10.1007/s004440050126 · Cited by 8
Self-citationEndometriosis-associated infertility
Haney, A. F. (1997) · Reproductive Medicine Review · doi:10.1017/s0962279900001496 · Cited by 8
Köhn, F.-M., Pflieger-Bruss, S., MULLER, C. H., Schuppe, H.-C., & Schill, W. B. (2002) · Steinkopff eBooks · doi:10.1007/978-3-642-57533-4_15 · Cited by 8
Ochsenkühn, R., Pavlik, R., Hecht, S., von Schönfeldt, V., Rogenhofer, N. N., & Thaler, C. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1284-9 · Cited by 7
Role of Progesterone in the Structural and Biochemical Remodeling of the Primate Endometrium
Slayden, O. D., & Brenner, R. (2006) · Springer eBooks · doi:10.1007/3-540-27147-3_5 · Cited by 7
Oppelt, P. G., Weber, M., Mueller, A., Boosz, A. S., Hoffmann, I., Raffel, N., Lotz, L., Beckmann, M. W., & Dittrich, R. (2018) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13428 · Cited by 7
The Structure, Function, and Evaluation of the Female Reproductive Tract
Lessey, B. A., & Young, S. L. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2758-2.00010-x · Cited by 8
Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract
Roan, N. R., & Jakobsen, M. R. (2016) · Current HIV/AIDS Reports · doi:10.1007/s11904-016-0305-0 · Cited by 7
Metadata
- Authors
- Leyendecker, G., Kunz, G., Wildt, L., Beil, D., & Deininger, H.
- Affiliations
- Klinikum Darmstadt (DE)
- Goethe University Frankfurt (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-07-01
- Volume
- 11
- Issue
- 7
- Pages
- 1542-1551
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W1992297132
- Cited by
- 307
- References
- 0
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 8 · 2021: 6 · 2020: 32 · 2019: 10 · 2018: 6 · 2017: 14 · 2016: 7 · 2015: 12 · 2014: 10 · 2013: 6 · 2012: 9
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- endometriosis, infertility, uterine peristalsis, sperm transport, menstrual cycle phases, follicular phase, luteal phase, retrograde menstruation, uterine motility
- MeSH terms
- Adult, Endometriosis, Fallopian Tubes, Female, Follicular Phase, Humans, Infertility, Female, Luteal Phase, Male, Middle Aged, Radionuclide Imaging, Sperm Transport, Ultrasonography, Uterine Contraction, Uterus, Case-Control Studies
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