The DOI matches its Crossref record.
Surgery: Adenomyosis at hysterectomy: a study on frequency distribution and patient characteristics
Abstract
To evaluate the prevalence and risk factors for adenomyosis, the clinical records of consecutive women undergoing hysterectomy during a 3 year period were retrieved. Data were collected on indication for the intervention, general sociodemographic characteristics of the patients, age at menarche, parity, abortions, and menopausal status at surgery. Adenomyosis was diagnosed in 332 of the 1334 cases (24.9%). The condition was present in 146 of the 627 patients (23.3%) with fibroids and menorrhagia, 68 of the 265 (25.7%) with prolapse, 21 of the 98 (21.4%) with ovarian cysts, 19 of the 100 (19%) with cervical cancer, 31 of the 110 (28.2%) with endometrial cancer, 16 of the 57 (28.1%) with ovarian cancer, and 19 of the 77 (24.7%) with miscellaneous indications. These differences were not statistically significant (chi 2(6) = 11.14). In comparison with nulliparous women, the odds ratio was 1.3 and 1.5 respectively in women with one and > or = two births (chi 2(1) trend = 5.76 P < 0.05). No relationship was found between age at surgery, age at menarche, indications for surgery, menopausal status at intervention, and presence of endometriosis. Our findings do not support the notion that adenomyosis is more frequently related to particular clinical conditions, and suggest that parity may be associated with an increased frequency of adenomyosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The primary observation regarding the prevalence of adenomyosis and fecundity has linked histologically proven adenomyosis at the time of hysterectomies to multiparity (34,35).”
From Endometrial receptivity in adenomyosis and/or endometriosis (2023) · cites this paper as [35]
Citations
Cited by
Sorted by citations
Items 101–175 of 175
Imaging Spectrum of Benign Uterine Disease and Treatment Options
Nougaret, S., Sbarra, M., & Robbins, J. B. (2019) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2019.10.004 · Cited by 11
Lonky, N. M., Chiu, V. Y., Portugal, C., Estrada, E. L., Chang, J. M., Fischer, H. J., Vora, J. B., Harrison, L. I., Peng, L., & Munro, M. G. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294925 · Cited by 15
Alternative treatments of adenomyosis – an update in procedural management and clinical outcomes
Zeccola, A. M., & Allen, S. E. (2024) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000972 · Cited by 10
Ma, R., Briones, D. A. B., Zou, M., Xiong, Y., Bai, J., & Zhang, L. (2024) · International Journal of Hyperthermia · doi:10.1080/02656736.2024.2390124 · Cited by 11
Chen, H., Wang, W., Wang, H., & Wang, X. (2022) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-04529-x · Cited by 10
How adenomyosis changes throughout pregnancy: A retrospective cohort study
Bertucci, E., Sileo, F. G., Diamanti, M., Alboni, C., Facchinetti, F., & Marca, A. L. (2022) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14383 · Cited by 10
Hysterectomy for benign gynecologic disorders
Crosignani, P. G., Aimi, G., Vercellini, P., & Meschìa, M. (1996) · Postgraduate Medicine · doi:10.3810/pgm.1996.12.131 · Cited by 10
Self-citationLoughlin, A. M., Chiuve, S. E., Reznor, G., Doherty, M., Missmer, S. A., Chomistek, A. K., & Enger, C. L. (2021) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.5333 · Cited by 9
Is adenomyosis associated with the risk of endometrial cancer?
Gün, İ., Öner, Ö., Bodur, S., Özdamar, Ö., & Atay, V. (2012) · PubMed · Cited by 9
Imaging and molecular features of adenomyosis after menopause
Vannuccini, S., Gabbrielli, S., Castiglione, F., Nardi, E., Rossi, M., Orlandi, G., Wu, E., Bertoli, F., Miele, V., Donati, C., et al. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.107996 · Cited by 8
The effect of adenomyosis on the outcomes of laparoscopic hysterectomy
Yavuzcan, A., Başbuğ, A., Baştan, M., Çağlar, M., & Ozdemir, I. (2016) · Journal of the Turkish-German Gynecological Association · doi:10.5152/jtgga.2016.16073 · Cited by 8
From Diagnosis to Fertility: Optimizing Treatment of Adenomyosis for Reproductive Health
Kim, H., Frisch, E. H., & Falcone, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13164926 · Cited by 8
“…(AI) and application to diagnosis of adenomyosis has been considered. prevalence of adenomyosis on hysterectomy pathology range from 15 to 57% [18,22,23]. adolescents with heavy menstrual In a recent publication, the role of AI in aiding in timely diagnoses was acknowledged along with…”
BackgroundInfluentialManduca, S., Mabud, T. S., Liu, S., Morris, E., Taslakian, B., & Kulkarni, K. (2024) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2024.12.001 · Cited by 7
Dolan, M. S., Hill, C. C., & Valea, F. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-65399-2.00027-9 · Cited by 9
Adenomyosis in Pregnancy—Should It Be Managed in High-Risk Obstetric Units?
Orozco, R., Jiménez, J. C. V., Garcia, I. B., Lozano, M., Hernández, G., Pérez-Rey, D., Meloni, L., & Alcázar, J. L. (2023) · Diagnostics · doi:10.3390/diagnostics13061184 · Cited by 7
“The prevalence of adenomyosis in hysterectomy specimens is estimated to be about 25% [1,6].”
BackgroundKhan, Z., & Stewart, E. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00026-3 · Cited by 7
The accuracy of transvaginal ultrasound and uterine artery Doppler in the prediction of adenomyosis
ElKattan, E. A., Omran, E., & Inany, H. G. A. (2010) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2010.04.003 · Cited by 6
Adenomyosis in a patient with mosaic Turner?s syndrome
Ferrero, S., & Bentivoglio, G. (2004) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-004-0603-4 · Cited by 6
Adenomyosis and coexisting gynecologic pathologies: How often do they coexist?
Çelik, H. G., Erkan, İ. B. Ö., Topçu, E. G., Sözen, I., Gündüz, N., Saricoban, C. T., İlvan, Ş., Demirkıran, F., & Oral, E. (2025) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.70261 · Cited by 5
“2,14 17 According to literature, adenomy-osis is identified in 20%–25% of hysterectomy specimens.”
Characterization of patients that can continue conservative treatment for adenomyosis
Miyagawa, C., Murakami, K., Tobiume, T., Nonogaki, T., & Matsumura, N. (2021) · BMC Women s Health · doi:10.1186/s12905-021-01577-x · Cited by 6
The Pathophysiology of Adenomyosis
Habiba, M. A., Benagiano, G., & Brosens, I. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-13012-5_3 · Cited by 5
Olgan, Ş., Dirican, E. K., Ozsipahi, A. C., & Sakıncı, M. (2021) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2021.05.013 · Cited by 5
THE ROLE OF MAGNETIC RESONANCE IMAGING IN THE EVALUATION OF GYNECOLOGIC DISEASE
Westphalen, A. C., & Qayyum, A. (2008) · Elsevier eBooks · doi:10.1016/b978-1-4160-3264-9.50037-9 · Cited by 5
Blum, S., Fasching, P. A., Hildebrandt, T., Lermann, J. H., Heindl, F., Born, T., Lubrich, H., Antoniadis, S., Becker, K., Fahlbusch, C., et al. (2021) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-021-06200-w · Cited by 5
Development and Maldevelopment of the Female Reproductive System
Castrillón, D. H. (2019) · Springer eBooks · doi:10.1007/978-981-13-3016-2_1 · Cited by 4
Khan, Z., & Stewart, E. A. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2758-2.00027-5 · Cited by 5
Cravello, L. (2006) · EMC - Gynécologie · doi:10.1016/s0246-1064(06)40217-6 · Cited by 5
Myometrial wall thickness ratio—A nomogram reference for diagnosing myometrial wall asymmetry
Garcia, D., Ivañez-Muñoz, M., Salazar, B., Ramirez, B., Olaso, F., & Alcázar, J. L. (2022) · Journal of Clinical Ultrasound · doi:10.1002/jcu.23189 · Cited by 4
“Nevertheless, in some series it rises up to 70% (based on pathological studies of hysterectomy).(2,3) Although the “reference standard” of the adenomyosis diagnosis is histological analysis, some imaging techniques, such as transvaginal ultrasound and magnetic resonance image, have acquired an important relevance in c…”
BackgroundThe role of MRI in the diagnosis of endometriosis
Ibrahim, N. M. A., & Elsaeed, H. H. (2012) · The Egyptian Journal of Radiology and Nuclear Medicine · doi:10.1016/j.ejrnm.2012.09.005 · Cited by 4
Demirtaş, G. S., & Uyar, İ. (2021) · Archives of Iranian Medicine · doi:10.34172/aim.2021.54 · Cited by 4
Use of Uterine Characteristics to Improve Fertility-Sparing Diagnosis of Adenomyosis
Ecker, A. M., Chamsy, D. J., Austin, R. M., et al. (2018) · Journal of Gynecologic Surgery · doi:10.1089/gyn.2017.0112 · Cited by 4
The Incidence and Clinical Significance of Adenomyosis
Habiba, M. A., & Benagiano, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-13012-5_2 · Cited by 4
Kolovos, G. N., Kalampokas, T., Dedes, I., et al. (2026) · Frontiers in Reproductive Health · doi:10.3389/frph.2026.1748474 · Cited by 3
Martire, F. G., d’Abate, C., Costantini, E., Bonis, M. D., Sorrenti, G., Centini, G., Zupi, E., & Lazzeri, L. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15110538 · Cited by 3
“Reported prevalence rates for adenomyosis range widely, from 1% to 70%, reflecting variability in diagnostic definitions and the historical reliance on postoperative histopathology [5,6].”
InfluentialRole of benign ovarian cysts in the development of adenomyosis
Alam, S., Ahmad, S., Khan, M. M., Nasir, S., Sharif, N., Ziaullah, S., Khalid, A., & Rauf, F. (2016) · Saudi Medical Journal · doi:10.15537/smj.2016.9.13599 · Cited by 3
Katz, V. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-323-06986-1.00018-4 · Cited by 3
Everyday Practice of 2D/3D Vaginal Ultrasound in Reproductive Gynecology
Petanovski, Z., & Kostova, E. P. (2020) · Donald School Journal of Ultrasound in Obstetrics & Gynecology · doi:10.5005/jp-journals-10009-1640 · Cited by 1
Ezejiofor, I., Olaofe, O. O., Chika, O., et al. (2020) · Nigerian Journal of Medicine · doi:10.4103/njm.njm_146_20 · Cited by 1
Knapman, B. L., Abbott, J. A., & Vyas, M. A. (2021) · Current Obstetrics and Gynecology Reports · doi:10.1007/s13669-021-00309-0 · Cited by 1
Huang, Y., Su, X., Chen, K., Zhang, L., Xu, W., Pu, Y., Xu, F., Gong, R., Zhang, J., Nie, Y., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-074488 · Cited by 2
Stewart, E. A. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00025-5 · Cited by 1
Sayan, C. D., Erdoğan, F., Yeral, M. İ., et al. (2018) · Ortadoğu Tıp Dergisi · doi:10.21601/ortadogutipdergisi.449994 · Cited by 1
Ormenezi, I., Ribeiro‐Silva, A., Silva, J. C. R. E., Meola, J., dos Reis, F. J. C., & Poli‐Neto, O. B. (2022) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2022e12375 · Cited by 1
“It was first described in the mid-19th century, and the estimated prevalence ranges from 10% to 30% in women of reproductive age (1).”
BackgroundCohen, I., Beyth, Y., Bernheim, J., et al. (1998) · Gynecologic and Obstetric Investigation · doi:10.1159/000010015 · Cited by 1
Chen, H., Wang, W., Wang, H., & Wang, X. (2020) · doi:10.22541/au.160037746.65054088 · Cited by 1
Steck, T. (2004) · Springer eBooks · doi:10.1007/978-3-7091-0574-0_2
Palmer, S. L., Darcy, N. F., Templeman, C. L., & Salibian, A. D. (2016) · CRC Press eBooks · doi:10.1201/b19531-5
Comment je fais… une adénomyomectomie utérine
Arfi, A., Chevalier, A. S., Sroussi, J., et al. (2017) · Gynécologie Obstétrique Fertilité & Sénologie · doi:10.1016/j.gofs.2017.03.006
Pregnancy Complications in Women with Adenomyosis
Tamura, H., & Sugino, N. (2018) · Comprehensive gynecology and obstetrics · doi:10.1007/978-981-10-7167-6_12
Assessment of the results of comprehensive examination in patients with adenomyosis
Klinyshkova, T. V., Frolova, N. B., Анатольевна, Ц. Е., Soveiko, E. E., & Chernyshova, N. P. (2019) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush20191901170
UTERINE ADENOMYOSIS IN SHE BUFFALOES: A HISTOPATHOLOGICAL STUDY.
Alfaris, A. A., & Fahid, T. A. (2009) · Basrah Journal of veterinary Research · doi:10.33762/bvetr.2009.55221
АНАЛІЗ КЛІНІКО-АНАМНЕСТИЧНИХ ДАНИХ І ПРЕМОРБІДНОГО ФОНУ ПРИ АДЕНОМІОЗІ
Scherbyna, М. О., & Чехунова, А. О. (2020) · Актуальні питання педіатрії акушерства та гінекології · doi:10.11603/24116-4944.2020.1.11493
Brölmann, H. A. M., Hehenkamp, W. J. K., & Huirne, J. A. F. (2014) · Springer eBooks · doi:10.1007/978-3-319-10305-1_8
The Clinical Features and Diagnosis of Adenomyosis
Dai, Y., & Leng, J. (2021) · Springer eBooks · doi:10.1007/978-981-33-4095-4_4
Classification of Uterine Adenomyosis
Zymperdikas, C., Mikos, T., & Grimbizis, G. (2022) · Current Obstetrics and Gynecology Reports · doi:10.1007/s13669-022-00337-4
Cravello, L. (2006) · EMC - Ginecología-Obstetricia · doi:10.1016/s1283-081x(06)46491-2
Bazot, M., Salem, C., Froment, V., & Chopier, J. (2006) · EMC - Radiologie et imagerie médicale - Génito-urinaire - Gynéco-obstétricale - Mammaire · doi:10.1016/s1879-8543(06)73977-5
Budden, A., & Abbott, J. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64528-2
Petraglia, F., & Vannuccini, S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732081604.793557170
Classification and Staging of Adenomyosis
Pados, G., & Daniilidis, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-97236-3_32
Current Trends and Future Strategies on Diagnosis and Management of Adenomyosis: An Updated Review
Bee, R., Ahmad, M., Verma, S. K., & Tiwari, R. K. (2024) · Current Women s Health Reviews · doi:10.2174/0115734048265172231018071749
Development and Maldevelopment of the Female Reproductive Tract
Castrillón, D. H. (2024) · Springer eBooks · doi:10.1007/978-981-19-7696-4_47-1
Alonso, A., Budden, A., & Abbott, J. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00238-8
Radiofrequency Ablation in Focal Uterine Adenomyoma: Long-Term Follow-up of 160 Cases
Scarperi, S., Fedele, F., Perandini, A., Bergamini, V., & Parazzini, F. (2024) · Journal of Gynecologic Surgery · doi:10.1089/gyn.2023.0124
Self-citationManagement of Common Benign Gynecologic Diseases in Postmenopausal Women
Yu, E., Lee, H., Joo, J. K., & Na, Y. J. (2024) · Journal of Menopausal Medicine · doi:10.6118/jmm.24017
(2000) · Time to knit · doi:10.1016/s1241-8218(02)00019-7
Development and Maldevelopment of the Female Reproductive Tract
Castrillón, D. H. (2025) · Springer eBooks · doi:10.1007/978-981-97-4822-8_47
NEZHAT, C. R., Nezhat, F. R., NEZHAT, C. R., Lakhi, N., & Nezhat, A. A. (2025) · Cambridge University Press eBooks · doi:10.1017/9781108561440.016
Shunji, Z., Peng, Y., Yi, T., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-8239654/v1
Magnetic resonance imaging (MRI) of the myometrium – benign and malignant disease
Albastawisy, S., Shapriya, K., Rockall, A. G., et al. (2026) · Clinical Radiology · doi:10.1016/j.crad.2026.107281
Epidemiology of endometriosis and adenomyosis
Upson, K., Missmer, S. A., Tellum, T., Harris, H. R., & As‐Sanie, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45863-7.00031-7
C-section induced adenomyosis, histopathological study of 429 cases of abdominal hysterectomy
Makki, J. S., Al-Shakarchi, A. M., & Alhamdany, A. S. (2026) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/22840265261468456
HACIOĞLU, L., & Karaaslan, O. (2026) · Research Square · doi:10.21203/rs.3.rs-10619173/v1
Naftalin, J. (2014) · UCL Discovery (University College London)
Metadata
- Authors
- Vercellini, P., Parazzini, F., Oldani, S., Panazza, S., Bramante, T., & Crosignani, P. G.
- Affiliations
- University of Milan (IT)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-05
- Volume
- 10
- Issue
- 5
- Pages
- 1160-1162
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W1904515219
- Cited by
- 175
- References
- 0
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 15 · 2023: 7 · 2022: 8 · 2021: 15 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 4 · 2012: 8
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- adenomyosis, hysterectomy, prevalence, risk factors, parity, nulliparity, endometriosis, uterine fibroids, menorrhagia, pelvic organ prolapse, ovarian cysts, cervical cancer, endometrial cancer, ovarian cancer, age at menarche, menopausal status
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Endometriosis, Female, Humans, Hysterectomy, Italy, Middle Aged, Parity, Risk Factors, Uterine Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
