The DOI matches its Crossref record.
Chorionic gonadotrophin-β mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes
Abstract
Human chorionic gonadotrophin beta (HCG-beta) is a trophoblast marker. Its expression is normally limited to syncytiotrophoblast cells of chorionic villi, although it is known to be secreted from the human embryo as early as 7 days post-fertilization. To examine the onset of embryonic transcriptional activity of the gene encoding this polypeptide we have performed in-situ hybridization to cellular RNAs of human tripronucleate preimplantation embryos. We see expression of HCG-beta RNA at the 6-8-cell stage, before morphological differentiation between trophectoderm and inner cell mass is apparent. We believe that this RNA is the product of de novo transcription from the embryonic genome, since transcripts are only observed in embryos of at least 2 days post-fertilization in age.
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The production of chorionic gonadotropin by the conceptus begins early, with expression of messenger RNA reported at the eight-cell stage.
“Its production by the conceptus begins early, with expression of messenger RNA reported at the eight-cell stage.25”
From Time of Implantation of the Conceptus and Loss of Pregnancy (1999) · cites this paper as [25]
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Time of Implantation of the Conceptus and Loss of Pregnancy
Wilcox, A. J., Baird, D. D., & Weinberg, C. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906103402304 · Cited by 1,081
Metadata
- Authors
- Bonduelle, M.-L., Dodd, R., Liebaers, I., Van Steirteghem, A., Williamson, R., & Akhurst, R.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-10
- Volume
- 3
- Issue
- 7
- Pages
- 909-914
- ISSN
- 1460-2350
- 0268-1161
- Cited by
- 123
- References
- 0
- Language
- en
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