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A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception
Abstract
A prospective randomized study was conducted at the Family Planning Association of Hong Kong to compare the efficacy of the Yuzpe regimen and levonorgestrel (0.75 mg for two doses 12 h apart) in post-coital contraception. A total of 424 subjects were recruited into the Yuzpe group and 410 subjects into the levonorgestrel group; 77 subjects in the Yuzpe group and 79 subjects in the levonorgestrel group had further acts of intercourse during the treatment cycle. Fifteen pregnancies (3.5%) occurred in the Yuzpe group and 12 pregnancies (2.9%) in the levonorgestrel group. After excluding the patients who had further acts of intercourse, the failure rates in the Yuzpe group and the levonorgestrel group were 2.6 and 2.4% respectively. The incidence of nausea, vomiting and fatigue in the Yuzpe group was significantly higher than those in the levonorgestrel group. We conclude that levonorgestrel is an effective drug for post-coital contraception with a lower incidence of side-effects than the Yuzpe regimen.
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Citations
Cited by
Interventions for emergency contraception
Shen, J., Che, Y., Showell, E., Chen, K., & Cheng, L. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001324.pub5 · Cited by 342
Timing of emergency contraception with levonorgestrel or the Yuzpe regimen
Piaggio, G., von Hertzen, H., Grimes, D., & Look, P. V. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05718-3 · Cited by 317
Interventions for emergency contraception
Shen, J., Che, Y., Showell, E., Chen, K., & Cheng, L. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001324.pub6 · Cited by 68
Metadata
- Authors
- Ho, P. C., & Kwan, M. S. W.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-03
- Volume
- 8
- Issue
- 3
- Pages
- 389-392
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2133458768
- Cited by
- 265
- References
- 0
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception. https://app.cochat.ai/papers/10.1093/oxfordjournals.humrep.a138057
- The paper
- Ho, P. C., & Kwan, M. S. W. (1993). A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception. Human Reproduction. https://doi.org/10.1093/oxfordjournals.humrep.a138057
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