Cited by 183Lipid metabolism and disordersLipid metabolism and biosynthesisAdipokines, Inflammation, and Metabolic Diseases

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Human Recombinant TNF Suppresses Lipoprotein Lipase Activity and Stimulates Lipolysis in 3T3-L1 Cells1

KAWAKAMI, Masanobu, MURASE, Toshio, OGAMA, Hiroko, ISHIBASHI, Shun, MORI, Natsuko, TAKAKU, Fumimaro, SHIBATA, Seiichi·1987·The Journal of Biochemistry

DOI 10.1093/oxfordjournals.jbchem.a121917

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Abstract

Tumor necrosis factor (TNF) has been reported to be identical to "cachectin," a monokine which we have previously proposed as a mediator of the enhanced catabolism observed in patients or animals responding to various invasive stimuli such as infections. Detailed quantitative studies were conducted on the effects of TNF on fatty acid metabolism in 3T3-L1 cells in order to explore the extent of the catabolic effects exerted by TNF compared with those by the crude cachectin. 3T3-L1 adipocytes responded to recombinant human TNF, showing a decrease in LPL activity and an increase in intracellular lipolysis. When TNF in the crude cachectin preparation was completely neutralized with anti-TNF antibody, about 75% of LPL suppression activity in the crude cachectin was absorbed, indicating that most of the mediator responsible for LPL suppression in the crude preparation is TNF. In contrast to the above effect on LPL, TNF markedly increased the lipolysis of stored fat in the cells. The effect on LPL was observed as early as 2 h after the addition of TNF, but enhancement of lipolysis required a time lag of at least 3 h before any increase of glycerol release became apparent. The effective concentrations of TNF for the stimulation of lipolysis were much higher (2.5 to 49 nM) than those for LPL suppression (50 pM to 50 nM), but both were in the same range as the concentration required for tumoricidal effect. These results demonstrate that cachectin is synonymous with TNF and that it plays an important role in the pathophysiology of deranged lipid metabolism through both suppression of LPL and enhancement of lipolysis in patients coping with invasive conditions such as infections.

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Additional file 3 of Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes
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Additional file 1 of Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes
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Authors: KAWAKAMI, M., MURASE, T., OGAMA, H., ISHIBASHI, S., MORI, N., TAKAKU, F., & SHIBATA, S.
Affiliations: Tokyo Medical Center (JP)
The University of Tokyo (JP)
ORCID: MURASE, Toshio
ISHIBASHI, Shun
Venue: The Journal of Biochemistry
Publisher: Oxford University Press (OUP)
Published: 1987-02
Volume: 101
Issue: 2
Pages: 331-338
ISSN: 0021-924X (ISSN-L)
1756-2651
DOI: 10.1093/oxfordjournals.jbchem.a121917
OpenAlex: W2177671852
Cited by: 183
References: 0
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 6
FWCI: 8.06
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: TNF-α, lipoprotein lipase, lipolysis, 3T3-L1 adipocytes, fatty acid metabolism, lipid degradation, glycerol release
MeSH terms: Adipose Tissue, Animals, Antibodies, Cell Line, Cell Survival, Fatty Acids, Glycoproteins, Humans, Interleukin-1, Lipolysis, Lipoprotein Lipase, Recombinant Proteins, Tumor Necrosis Factor-alpha

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Human Recombinant TNF Suppresses Lipoprotein Lipase Activity and Stimulates Lipolysis in 3T3-L1 Cells1

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