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Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains
Abstract
Recombinant inbred (RI) strains are extremely useful for genetic mapping. This paper presents a simple method for determining confidence intervals for linkage estimates based on analysis of RI strains. The results show that such confidence intervals are usually large with the currently available numbers of RI strains. Therefore, map positions based only on analysis of RI strains should be interpreted with caution. To facilitate interpretation of linkage data derived from RI strains, a table is presented giving the 95 percent and 99 percent confidence intervals for all possible linkages detected with up to 45 RI strains.
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Cited by
Oct-4: a germline-specific transcription factor mapping to the mouse t-complex.
Schöler, H. R., Dressler, G. R., Balling, R., Rohdewohld, H., & Gruss, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07388.x · Cited by 586
Avraham, S., London, R., Fu, Y., Ota, S., Hiregowdara, D., Li, J., Jiang, S., Pasztor, L. M., White, R. A., Groopman, J. E., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27742 · Cited by 359
Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice
Frankel, W. N., Rudy, C., Coffin, J. M., & Huber, B. T. (1991) · Nature · doi:10.1038/349526a0 · Cited by 306
Genetic factors controlling structure and expression of apolipoproteins B and E in mice.
Lusis, A. J., Taylor, B. A., Quon, D., Zollman, S., & LeBoeuf, R. C. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47607-7 · Cited by 144
Struyk, A., Canoll, P., Wolfgang, M., Rosen, C., D'Eustachio, P., & Salzer, J. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02141.1995 · Cited by 142
Metadata
- Authors
- Silver, J.
- Venue
- Journal of Heredity
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-11
- Volume
- 76
- Issue
- 6
- Pages
- 436-440
- ISSN
- 0022-1503 (ISSN-L)
- 1465-7333
- OpenAlex
- W2289896666
- Cited by
- 226
- References
- 0
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Silver, J. (1985). Confidence limits for estimates of gene linkage based on analysis of recombinant inbred strains. Journal of Heredity. https://doi.org/10.1093/oxfordjournals.jhered.a110140
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
