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Cited by 220

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Two Cyp19 (P450 Aromatase) Genes on Duplicated Zebrafish Chromosomes Are Expressed in Ovary or Brain

Open access
Chiang, Evelyn Feng-Lin, Yan, Yi-Lin, Guiguen, Yann, Postlethwait, John, Chung, Bon-chu·2001·Molecular Biology and Evolution

Abstract

Cytochrome P450 aromatase (Cyp19) is an enzyme catalyzing the synthesis of estrogens, thereby controlling various physiological functions of estrogens. We isolated two cyp19 cDNAs, termed cyp19a and cyp19b, respectively, from zebrafish. These genes are located in linkage groups 18 and 25, respectively. Detailed gene mapping indicated that zebrafish linkage groups 18 and 25 may have arisen from the same ancestral chromosome by a chromosome duplication event. Cyp19a is expressed mainly in the follicular cells lining the vitellogenic oocytes in the ovary during vitellogenesis. Cyp19b is expressed abundantly in the brain, at the hypothalamus and ventral telencephalon, extending to the olfactory bulbs. The expression of duplicated cyp19 genes at two different tissues highlights the evolutionary significance of maintaining two active genes on duplicated zebrafish chromosomes for specific functions in the ovary and the brain.

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Metadata

Authors
Chiang, E. F.-L., Yan, Y.-L., Guiguen, Y., Postlethwait, J., & Chung, B.-C.
Venue
Molecular Biology and Evolution
Published
2001-04-01
Volume
18
Issue
4
Pages
542-550
ISSN
  • 0737-4038 (ISSN-L)
  • 1537-1719
OpenAlex
W2161193684
Cited by
220
References
3
FWCI
5.19
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Two Cyp19 (P450 Aromatase) Genes on Duplicated Zebrafish Chromosomes Are Expressed in Ovary or Brain. https://app.cochat.ai/papers/10.1093/oxfordjournals.molbev.a003833
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Chiang, E. F.-L., Yan, Y.-L., Guiguen, Y., Postlethwait, J., & Chung, B.-C. (2001). Two Cyp19 (P450 Aromatase) Genes on Duplicated Zebrafish Chromosomes Are Expressed in Ovary or Brain. Molecular Biology and Evolution. https://doi.org/10.1093/oxfordjournals.molbev.a003833

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