The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Prokaryotic Evolution in Light of Gene Transfer
Abstract
Accumulating prokaryotic gene and genome sequences reveal that the exchange of genetic information through both homology-dependent recombination and horizontal (lateral) gene transfer (HGT) is far more important, in quantity and quality, than hitherto imagined. The traditional view, that prokaryotic evolution can be understood primarily in terms of clonal divergence and periodic selection, must be augmented to embrace gene exchange as a creative force, itself responsible for much of the pattern of similarities and differences we see between prokaryotic microbes. Rather than replacing periodic selection on genetic diversity, gene loss, and other chromosomal alterations as important players in adaptive evolution, gene exchange acts in concert with these processes to provide a rich explanatory paradigm-some of whose implications we explore here. In particular, we discuss (1) the role of recombination and HGT in giving phenotypic "coherence" to prokaryotic taxa at all levels of inclusiveness, (2) the implications of these processes for the reconstruction and meaning of "phylogeny," and (3) new views of prokaryotic adaptation and diversification based on gene acquisition and exchange.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The recognition that substantial horizontal gene transfer (HGT) has occurred between microorganisms raised concerns that genes might be transferred with high enough frequency as to seriously challenge the notion of a universal tree of life (e.g.Doolittle 1999; Gogarten et al. 2002).”
From The Emergence of Life (2019) · cites this paper as Gogarten et al. 2002
Citations
Cites
Mayr, E. (1963) · doi:10.4159/harvard.9780674865327 · Cited by 10,175
Lateral gene transfer and the nature of bacterial innovation
Ochman, H., Lawrence, J. G., & Groisman, E. A. (2000) · Nature · doi:10.1038/35012500 · Cited by 3,816
Self-citationSystematics and the Origin of Species
National Academy of Sciences (2005) · National Academies Press eBooks · doi:10.17226/11310 · Cited by 3,451
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
Perna, N. T., Plunkett, G., Burland, V., Mau, B., Glasner, J. D., Rose, D. J., Mayhew, G. F., Evans, P. S., Gregor, J., Kirkpatrick, H. A., et al. (2001) · Nature · doi:10.1038/35054089 · Cited by 2,035
Phylogenetic Classification and the Universal Tree
Doolittle, W. F. (1999) · Science · doi:10.1126/science.284.5423.2124 · Cited by 1,888
Self-citationNelson, K. E., Clayton, R. A., Gill, S. R., Gwinn, M. L., Dodson, R. J., Haft, D. H., Hickey, E. K., Peterson, J. D., Nelson, W. C., Ketchum, K. A., et al. (1999) · Nature · doi:10.1038/20601 · Cited by 1,493
High Frequency of Hypermutable Pseudomonas aeruginosa in Cystic Fibrosis Lung Infection
Oliver, A., Cantón, R., Campo, P., Baquero, F., & Blázquez, J. (2000) · Science · doi:10.1126/science.288.5469.1251 · Cited by 1,466
Pathogenicity Islands and the Evolution of Microbes
Hacker, J. H., & Kaper, J. B. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.641 · Cited by 1,298
Horizontal gene transfer among genomes: The complexity hypothesis
Jain, R., Rivera, M. C., & Lake, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3801 · Cited by 1,170
Molecular archaeology of the Escherichia coli genome
Lawrence, J. G., & Ochman, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9413 · Cited by 939
Self-citation
Research works printed but not linked: 1
- Wright S., 1932 The roles of mutation, inbreeding, crossbreeding, and selection in evolution Proc. 6th Int. Congr. Genet1:356-366
Cited by
Sorted by citations
The Microbial Engines That Drive Earth's Biogeochemical Cycles
Falkowski, P. G., Fenchel, T., & Delong, E. F. (2008) · Science · doi:10.1126/science.1153213 · Cited by 3,379
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
Mobile genetic elements: the agents of open source evolution
Frost, L. S., Leplae, R., Summers, A. O., & Toussaint, A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1235 · Cited by 1,839
Toward Automatic Reconstruction of a Highly Resolved Tree of Life
Ciccarelli, F. D., Doerks, T., von Mering, C., Creevey, C. J., Snel, B., & Bork, P. (2006) · Science · doi:10.1126/science.1123061 · Cited by 1,663
Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes
Timmis, J. N., Ayliffe, M., Huang, C. Y., & Martin, W. F. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1271 · Cited by 1,603
Metadata
- Authors
- Gogarten, J. P., Doolittle, W. F., & Lawrence, J. G.
- Affiliations
- University of Connecticut (US)
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-01
- Volume
- 19
- Issue
- 12
- Pages
- 2226-2238
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2110105435
- Cited by
- 986
- References
- 132
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 19 · 2023: 18 · 2022: 27 · 2021: 31 · 2020: 37 · 2019: 31 · 2018: 33 · 2017: 32 · 2016: 45 · 2015: 39 · 2014: 47 · 2013: 57 · 2012: 51
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Biology and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- David and Lucile Packard Foundation
- National Aeronautics and Space Administration
- Canadian Institute for Advanced Research
- Canada Research Chairs
- Health Canada
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- prokaryotic evolution, horizontal gene transfer, homologous recombination, genetic exchange, phylogeny, diversification, gene loss, clonal divergence
- MeSH terms
- Phylogeny, Prokaryotic Cells, Evolution, Molecular, Gene Transfer, Horizontal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
