The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.
Molecular Clocks in Reptiles: Life History Influences Rate of Molecular Evolution
Open accessAbstract
Life history has been implicated as a determinant of variation in rate of molecular evolution amongst vertebrate species because of a negative correlation between body size and substitution rate for many molecular data sets. Both the generality and the cause of the negative body size trend have been debated, and the validity of key studies has been questioned (particularly concerning the failure to account for phylogenetic bias). In this study, a comparative method has been used to test for an association between a range of life-history variables-such as body size, age at maturity, and clutch size-and DNA substitution rate for three genes (NADH4, cytochrome b, and c-mos). A negative relationship between body size and rate of molecular evolution was found for phylogenetically independent pairs of reptile species spanning turtles, lizards, snakes, crocodile, and tuatara. Although this study was limited by the number of comparisons for which both sequence and life-history data were available, the results suggest that a negative body size trend in rate of molecular evolution may be a general feature of reptile molecular evolution, consistent with similar studies of mammals and birds. This observation has important implications for uncovering the mechanisms of molecular evolution and warns against assuming that related lineages will share the same substitution rate (a local molecular clock) in order to date evolutionary divergences from DNA sequences.
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“The predicted correlation of generation time with mutation rate 24 has been supported by studies that compare the rates of molecular evolution with generation time (or its correlate, body size) across a range of genes for several vertebrate species 35,37-39 .”
From The modern molecular clock (2003) · cites this paper as [38]
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Cites
PAUP^* : Phylogenetic Analysis Using Parsimony (and other methods) 4.0b8
Swofford, D. L. (2001) · Cited by 12,789
Phylogenies and the Comparative Method
Felsenstein, J. (1985) · The American Naturalist · doi:10.1086/284325 · Cited by 9,793
Molecular Markers, Natural History and Evolution
Avise, J. C. (1994) · Springer eBooks · doi:10.1007/978-1-4615-2381-9 · Cited by 5,210
The comparative method in evolutionary biology
Harvey, P., & Pagel, M. (1991) · Choice Reviews Online · doi:10.5860/choice.29-5104 · Cited by 4,778
The Comparative Method in Evolutionary Biology
Harvey, P. H., & Pagel, M. D. (1991) · doi:10.1093/oso/9780198546412.001.0001 · Cited by 4,337
Body size, metabolic rate, generation time, and the molecular clock.
Martin, A. P., & Palumbi, S. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4087 · Cited by 1,239 · cited 8×
“…included (Spearman: rS 5 0.48, P 5 0.01; Pearson: r 5 0.56, P 5 0.02). mura, and Sharp 1987; Ohta 1993; Eyre-Walker and Gaut 1997), and yet the body size effect is also a feature of total genetic distance and nonsynonymous rate (this study; Martin and Palumbi 1993; Mooers and Harvey 1994).”
BackgroundInfluentialA nonparametric approach to estimating divergence times in the absence of rate constancy.
Sanderson, M. J. (1997) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025731 · Cited by 1,156 · cited 1×
“A lifehistory trend in rate of molecular evolution suggests that rates of molecular evolution must evolve over trees as life-history traits evolve, posing a dynamic picture of rate of molecular evolution, which complicates molecular phylogenetic inference (Sanderson 1997).”
BackgroundEvidence for higher rates of nucleotide substitution in rodents than in man.
Wu, C., & Li, W. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.6.1741 · Cited by 909
Rates of DNA sequence evolution differ between taxonomic groups.
Britten, R. J. (1986) · Science · doi:10.1126/science.3082006 · Cited by 782
The Biology of Sea Turtles, Volume I
(2017) · CRC Press eBooks · doi:10.1201/9780203737088 · Cited by 728
Research works printed but not linked: 6
- Campbell B. N., 1997 Hic Sunt Serpentes—molecular phylogenetics and the Boidae (Serpentes: Booidea) Doctoral dissertation, Queen's University, Kingston, Ontario, Canada
- Ernst C. H., R. W. Barbour, 1989 Turtles of the world Smithsonian Institution Press, Washington
- Harless M., H. Morlock, 1979 Turtle perspectives and research John Wiley, New York
- Heatwole H., 1999 Sea snakes University of New South Wales (UNSW) Press, Sydney
- Hubert J., 1985 The origin and development of oocytes Pp. 41–74 in C. Gans, F. Billet, and P. F. A. Maderson, eds. Biology of the Reptilia: development A. John Wiley & Sons, New York
- Miller J. D., 1997 Reproduction in sea turtles Pp. 51–82 in P. L. Lutz and J. A. Musick, eds. The biology of sea turtles. CRC Press, Boca Raton
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Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
Computational Molecular Evolution
Yang, Z. (2006) · doi:10.1093/acprof:oso/9780198567028.001.0001 · Cited by 1,152
Species–energy relationships at the macroecological scale: a review of the mechanisms
Evans, K. L., Warren, P. H., & Gaston, K. J. (2005) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793104006517 · Cited by 768
“Conversely, other studies report that body size influences molecular evolution rates in reptiles and mammals (Bromham, Rambaut & Harvey, 1996; Bromham, 2002).”
BackgroundBromham, L., & Penny, D. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1020 · Cited by 615
Self-citationMolecular clocks: four decades of evolution
Kumar, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1659 · Cited by 422
“In 1993, an inverse relationship between the rate of DNA evolution and body size was observed for some genes and specie”
Background
Metadata
- Authors
- Bromham, L.
- Affiliations
- University of Sussex (GB)
- Corresponding author
- Bromham, Lindell
- ORCID
- Bromham, Lindell
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-03-01
- Volume
- 19
- Issue
- 3
- Pages
- 302-309
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2152489289
- Cited by
- 142
- References
- 64
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 11 · 2012: 4
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Biology and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- molecular clock, molecular evolution rate, life history, body size, reptiles, phylogenetic bias, age at maturity, clutch size, cytochrome b, c-mos, turtles, lizards, snakes, crocodiles, tuatara, divergence time estimation
- MeSH terms
- Aging, Animals, Body Constitution, Cytochrome b Group, Environment, Litter Size, Models, Genetic, NAD, Phylogeny, Reptiles, Sexual Maturation, Species Specificity, Time Factors, Mutagenesis, Proto-Oncogene Proteins c-mos, Evolution, Molecular
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