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Evolution of primate ABO blood group genes and their homologous genes
Open accessAbstract
There are three common alleles (A, B, and O) at the human ABO blood group locus. We compared nucleotide sequences of these alleles, and relatively large numbers of nucleotide differences were found among them. These differences correspond to the divergence time of at least a few million years, which is unusually large for a human allelic divergence under neutral evolution. We constructed phylogenetic networks of human and nonhuman primate ABO alleles, and at least three independent appearances of B alleles from the ancestral A form were observed. These results suggest that some kind of balancing selection may have been operating at the ABO locus. We also constructed phylogenetic trees of ABO and their evolutionarily related alpha-1,3-galactosyltransferase genes, and the divergence time between these two families was estimated to be roughly 400 MYA.
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Cited by
Mallet, J., Besansky, N., & Hahn, M. W. (2016) · BioEssays · doi:10.1002/bies.201500149 · Cited by 586
Host–pathogen co-evolution and glycan interactions
Le Pendu, J., Nyström, K., & Ruvoën-Clouet, N. (2014) · Current Opinion in Virology · doi:10.1016/j.coviro.2014.06.001 · Cited by 79
Sexual selection by female immunity against paternal antigens can fix loss of function alleles
Ghaderi, D., Springer, S. A., Ma, F., Cohen, M., Secrest, P., Taylor, R. E., Varki, A., & Gagneux, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102302108 · Cited by 79
ABO blood group glycans modulate sialic acid recognition on erythrocytes
Cohen, M., Hurtado-Ziola, N., & Varki, A. (2009) · Blood · doi:10.1182/blood-2009-06-227041 · Cited by 75
Metadata
- Authors
- Saitou, N., & Yamamoto, F.
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-04-01
- Volume
- 14
- Issue
- 4
- Pages
- 399-411
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2143562461
- Cited by
- 158
- References
- 0
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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