The DOI matches its Crossref record.
Statistical tests for detecting gene conversion.
Abstract
Statistical tests for detecting gene conversion are described for a sample of homologous DNA sequences. The tests are based on imbalances in the distribution of segments on which some pair of sequences agrees. The methods automatically control for variable mutation rates along the genome and do not depend on a priori choices of potentially monophyletic subsets of the sample. The tests show strong evidence for multiple intragenic conversion events at two loci in Escherichia coli. The gnd locus in E. coli shows a highly significant excess of maximal segments of length 70-200 bp, which suggests conversion events of that size. The data also indicate that the rate of these short conversion events might be of the order of neutral mutation rate. There is also evidence for correlated mutation in adjacent codon positions. The same tests applied to a locus in an RNA virus were negative.
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Cited by
Croucher, N. J., Page, A. J., Connor, T. R., Delaney, A. J., Keane, J. A., Bentley, S. D., Parkhill, J., & Harris, S. R. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1196 · Cited by 2,741
Analyzing the mosaic structure of genes
Smith, J. (1992) · Journal of Molecular Evolution · doi:10.1007/bf00182389 · Cited by 1,625
RDP: detection of recombination amongst aligned sequences
Martin, D., & Rybicki, E. (2000) · Bioinformatics · doi:10.1093/bioinformatics/16.6.562 · Cited by 1,532
RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL
Domingo, E., & Holland, J. J. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.151 · Cited by 1,514
A Simple and Robust Statistical Test for Detecting the Presence of Recombination
Bruen, T. C., Philippe, H., & Bryant, D. (2006) · Genetics · doi:10.1534/genetics.105.048975 · Cited by 1,382
Metadata
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-09
- Volume
- 6
- Issue
- 5
- Pages
- 526-38
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2171022989
- Cited by
- 861
- References
- 0
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Statistical tests for detecting gene conversion. (1989). Molecular Biology and Evolution. https://doi.org/10.1093/oxfordjournals.molbev.a040567
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