The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The statistical analysis of mitochondrial DNA polymorphisms: chi 2 and the problem of small samples.
Open accessAbstract
Significance levels obtained from a chi 2 contingency test are suspect when sample sizes are small. Traditionally this has meant that data must be combined. However, such an approach may obscure heterogeneity and hence potentially reduce the power of the statistical test. In this paper, we present a Monte Carlo solution to this problem: by this method, no lumping of data is required, and the accuracy of the estimate of alpha (i.e., a type 1 error) depends only on the number of randomizations of the original data set. We illustrate this technique with data from mtDNA studies, where numerous genotypes are often observed and sample sizes are relatively small.
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Cites
Baltosser, W. H., & Zar, J. H. (1996) · Ecology · doi:10.2307/2265725 · Cited by 35,166
Zar, J. H. (1996) · Cited by 7,837
Some Methods for Strengthening the Common χ 2 Tests
Cochran, W. G. (1954) · Biometrics · doi:10.2307/3001616 · Cited by 3,718 · cited 1×
“Cochran ( 1954) suggested that a reasonable rule of thumb is that no expected frequency should be 1 .”
BackgroundBirky, C. W., Maruyama, T., & Fuerst, P. (1983) · Genetics · doi:10.1093/genetics/103.3.513 · Cited by 719
Aspects of the population genetics of Mytilus (Mytilidae; Mollusca) in the British Isles
SKIBINSKI, D. O. F., BEARDMORE, J. A., & CROSS, T. F. (1983) · Biological Journal of the Linnean Society · doi:10.1111/j.1095-8312.1983.tb00782.x · Cited by 228
Cited by
Separating the wheat from the chaff: patterns of genetic differentiation in high gene flow species
Waples, R. S. (1998) · Journal of Heredity · doi:10.1093/jhered/89.5.438 · Cited by 1,292
Mitochondrial DNA phylogeography and population history of the grey wolf Canis lupus
Vilà, C., Amorim, I. R., Leonard, J. A., Posada, D., Castroviejo, J., Petrucci‐Fonseca, F., Crandall, K. A., Ellegren, H., & Wayne, R. K. (1999) · Molecular Ecology · doi:10.1046/j.1365-294x.1999.00825.x · Cited by 367
Hendry, A. P., Taylor, E. B., & McPhail, J. D. (2002) · Evolution · doi:10.1111/j.0014-3820.2002.tb01432.x · Cited by 357
The “Eve” Hypotheses: A Genetic Critique and Reanalysis
Templeton, A. R. (1993) · American Anthropologist · doi:10.1525/aa.1993.95.1.02a00030 · Cited by 295
O'Corry‐Crowe, G. M., Suydam, R. S., Rosenberg, A., Frost, K. J., & Dizon, A. E. (1997) · Molecular Ecology · doi:10.1046/j.1365-294x.1997.00267.x · Cited by 263
Metadata
- Venue
- Molecular Biology and Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-09
- Volume
- 6
- Issue
- 5
- Pages
- 539-45
- ISSN
- 0737-4038 (ISSN-L)
- 1537-1719
- OpenAlex
- W2109678076
- Cited by
- 867
- References
- 5
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The statistical analysis of mitochondrial DNA polymorphisms: chi 2 and the problem of small samples. (1989). Molecular Biology and Evolution. https://doi.org/10.1093/oxfordjournals.molbev.a040568
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