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CORTICOSTEROID-INDUCED SUPPRESSION OF THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS: OBSERVATIONS ON PATIENTS GIVEN ORAL CORTICOSTEROIDS FOR RHEUMATOID ARTHRITIS
Abstract
MUKUNDRAI K. JASANI, JAMES A. BOYLE, WILLIAM R. GREIG, THEODORE G. DALAKOS, MARGARET C. K. BROWNING, ANNE THOMPSON, W. WATSON BUCHANAN; CORTICOSTEROID-INDU
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“Long-acting glucocorticoids such as dexamethasone or betamethasone, even in physiologic daily dose equivalent, are more likely to cause HPA axis suppression, exogenous Cushing syndrome, and glucocorticoid withdrawal syndrome when being tapered (24, 74-78).”
From European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and Therapy of Glucocorticoid-induced Adrenal Insufficiency (2024) · cites this paper as [77]
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Metadata
- Authors
- JASANI, M. K., BOYLE, J. A., GREIG, W. R., DALAKOS, T. G., BROWNING, M. C. K., THOMPSON, A., & BUCHANAN, W. W.
- Venue
- QJM: An International Journal of Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1967-07-01
- Volume
- 36
- Issue
- 3
- Pages
- 261-276
- ISSN
- 0033-5622 (ISSN-L)
- 1460-2393
- 1460-2725
- OpenAlex
- W2107679660
- Cited by
- 78
- References
- 0
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2016: 3 · 2014: 1 · 2013: 2
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- QJM (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- hypothalamic-pituitary-adrenal axis, oral corticosteroids, rheumatoid arthritis, glucocorticoid therapy, adrenal function
- MeSH terms
- Adrenal Glands, Adult, Arthritis, Rheumatoid, Blood Glucose, Female, Glucocorticoids, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Insulin, Lysine, Metyrapone, Middle Aged, Pituitary-Adrenal Function Tests, Pituitary-Adrenal System, Vasopressins, 17-Hydroxycorticosteroids
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