The Effects of Long-Term Ketamine Treatment on Cognitive Function in Complex Regional Pain Syndrome: A Preliminary Study
Open accessAbstract
OBJECTIVE: This preliminary study aimed to investigate the effects of long-term frequent ketamine treatment on cognitive function in [AQ-A] CRPS patients. DESIGN: A total of 30 CRPS patients were divided into two groups based on both the duration and frequency of ketamine treatment; the long-term frequent ketamine treatment (LF) group (N = 14) and the Non-LF group (N = 16). Participants were asked to complete a questionnaire packet including demographic and clinical characteristics and potential variables affecting cognitive function. Then, they performed the neuropsychological test. RESULTS: Results indicated that the LF group performed significantly poorer than the Non-LF group on the digit span, digit symbol, Controlled Oral Word Association Test, and Trail Making Test, but not the Stroop task. CONCLUSIONS: Patients with CRPS receiving long-term frequent ketamine treatment showed impairment in cognitive function (specifically executive function) compared with those who do not. These findings may have implications for clinical assessment and rehabilitation of cognitive function in CRPS patients.
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Cognitive deficits were only seen in the frequent user group in a small group of regional pain disorders versus less frequent users.
“Cognitive deficits were also only seen in very frequent users (over four times weekly) in a study of chronic self-administered ketamine177 and the frequent user group in a small group of regional pain disorders178 versus people who used ketamine less often.”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [178]
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Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
Executive functions, self-regulation, and chronic pain: a review
Solberg Nes, L., Roach, A. R., & Segerstrom, S. C. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9096-5 · Cited by 242 · see citing works
Effects of chronic ketamine use on frontal and medial temporal cognition
Chan, K. W. S., Lee, T. M. C., Siu, A. M. H., Wong, D. P. L., Kam, C.-M., Tsang, S. K. M., & Chan, C. C. H. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.01.014 · Cited by 65 · see citing works
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Research works printed but not linked: 23
- 10.1016/j.pain.2006.09.008 · DOI
- 10.1016/0304-3959(95)00110-E · DOI
- 10.1016/S0885-3924(00)00183-4 · DOI
- 10.1016/j.pain.2009.06.023 · DOI
- Sharanya, 2010, The use of sub-anesthetic intravenous ketamine and adjuvant dexmedetomidine when treating acute pain from CRPS, Pain Physician, 13, 365
- 10.1111/j.1526-4637.2007.00314.x · DOI
- 10.1016/j.acn.2007.05.005 · DOI
- Ceber, 2006, Katamine may be the first choice for anesthesia in burn patients, J Burn Care Res, 5, 760, 10.1097/01.BCR.0000238091.41737.7C · DOI
- 10.1016/j.ejpain.2011.03.008 · DOI
- 10.1111/j.1360-0443.2008.02394.x · DOI
- 10.1016/j.biopha.2006.06.021 · DOI
- 10.1046/j.1360-0443.2000.9545759.x · DOI
- 10.1046/j.1360-0443.2001.96574910.x · DOI
- 10.1007/s00213-006-0572-3 · DOI
- 10.1111/bcp.12157 · DOI
- 10.1001/archinternmed.2011.1827 · DOI
- Spreen O Benton AL. Neurosensory Center Comprehensive Examination for Aphasia: Manual of instructions. Revised edition. Victoria, BC, Canada: Neuropsychology Laboratory, University of Victoria, 1977.
- 10.2466/pms.1958.8.3.271 · DOI
- 10.1016/0006-8993(94)91558-X · DOI
- Verma, 1996, NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: Modulation by dopamine, J Neurosci, 16, 373, 10.1523/JNEUROSCI.16-01-00373.1996 · DOI
- 10.3171/jns.2003.98.1.0175 · DOI
- 10.1016/j.pneurobio.2011.01.002 · DOI · Paper page
- 10.1016/j.ijpsycho.2013.02.001 · DOI
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Matveychuk, D., Thomas, R. K., Swainson, J., Khullar, A., MacKay, M.-A., Baker, G. B., & Dursun, S. M. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320916657 · Cited by 209 · see citing works
Van Amsterdam, J., & Van Den Brink, W. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2021.1949454 · Cited by 44 · see citing works
- Authors
- Kim, M., Cho, S., & Lee, J.-H.
- Affiliations
- Chung-Ang University (KR)
- Chungnam National University (KR)
- Venue
- Pain Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-02-27
- Volume
- 17
- Issue
- 8
- Pages
- 1447-1451
- ISSN
- 1526-2375 (ISSN-L)
- 1526-4637
- OpenAlex
- W2324081848
- Cited by
- 30
- References
- 3
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pain Medicine (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Keywords
- complex regional pain syndrome, ketamine, cognitive function, executive function, neuropsychological assessment, treatment duration and frequency, digit span, Trail Making Test, Controlled Oral Word Association Test, Stroop task
- MeSH terms
- Adult, Analgesics, Cognition, Female, Humans, Ketamine, Male, Middle Aged, Neuropsychological Tests, Complex Regional Pain Syndromes
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