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Stable, soluble T-cell receptor molecules for crystallization and therapeutics
Open accessAbstract
Antibody and T-cell receptors (TCRs) are the primary recognition molecules of the adaptive immune system. Antibodies have been extensively characterized and are being developed for a large number of therapeutic applications. This has been possible because of the ability to manufacture stable, soluble, monoclonal antibodies which retain the antigen specificity of B cells. Unlike antibodies, TCRs are not expressed in a soluble form, but are anchored to the T-cell surface by an insoluble trans-membrane domain. Characterization and development of TCRs has been hampered by the lack of suitable methods for producing them as soluble and stable proteins. Here we report the engineering of soluble human TCRs suitable for crystallization studies and potentially for in vivo therapeutic use.
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Cited by
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Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions
Robbins, P. F., Li, Y. F., El-Gamil, M., Zhao, Y., Wargo, J. A., Zheng, Z., Xu, H., Morgan, R. A., Feldman, S. A., Johnson, L. A., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6116 · Cited by 383
Self-citationMonoclonal TCR-redirected tumor cell killing
Liddy, N., Bossi, G., Adams, K. J., Lissina, A., Mahon, T. M., Hassan, N. J., Gavarret, J., Bianchi, F. C., Pumphrey, N. J., Ladell, K., et al. (2012) · Nature Medicine · doi:10.1038/nm.2764 · Cited by 324
Self-citationTargeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies
Maciocia, P. M., Wawrzyniecka, P. A., Philip, B., Ricciardelli, I., Akarca, A. U., Onuoha, S. C., Legut, M., Cole, D. K., Sewell, A. K., Gritti, G., et al. (2017) · Nature Medicine · doi:10.1038/nm.4444 · Cited by 286
Metadata
- Authors
- Boulter, J. M., Glick, M., Todorov, P. T., Baston, E., Sami, M., Rizkallah, P., & Jakobsen, B. K.
- Venue
- Protein Engineering Design and Selection
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09-01
- Volume
- 16
- Issue
- 9
- Pages
- 707-711
- ISSN
- 0269-2139 (ISSN-L)
- 1741-0126
- 1741-0134
- OpenAlex
- W2116117984
- Cited by
- 276
- References
- 0
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Stable, soluble T-cell receptor molecules for crystallization and therapeutics. https://app.cochat.ai/papers/10.1093/protein/gzg087
- The paper
- Boulter, J. M., Glick, M., Todorov, P. T., Baston, E., Sami, M., Rizkallah, P., & Jakobsen, B. K. (2003). Stable, soluble T-cell receptor molecules for crystallization and therapeutics. Protein Engineering Design and Selection. https://doi.org/10.1093/protein/gzg087
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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