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Cited by 22Bone Tissue Engineering MaterialsDental Implant Techniques and OutcomesNanoparticles: synthesis and applications

A homogeneous dopamine–silver nanocomposite coating: striking a balance between the antibacterial ability and cytocompatibility of dental implants

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Wang, Shuang, Wu, Zichen, Wang, Yankai, Hong, Huilei, Zhang, Lijie, Chen, Zhaoyang, Zhang, Pengkang, Chen, Zirui +7 more·2023·Regenerative Biomaterials
DOI 10.1093/rb/rbac082PMC PMC9847628
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Abstract

Silver has been widely used for surface modification to prevent implant-associated infections. However, the inherent cytotoxicity of silver greatly limited the scope of its clinical applications. The construction of surfaces with both good antibacterial properties and favorable cytocompatibility still remains a challenge. In this study, a structurally homogeneous dopamine–silver (DA/Ag) nanocomposite was fabricated on the implant surface to balance the antibacterial activity and cytocompatibility of the implant. The results show that the DA/Ag nanocomposites prepared under the acidic conditions (pH = 4) on the titanium surface are homogeneous with higher Ag+ content, while an obvious core (AgNPs)–shell (PDA) structure is formed under neutral (pH = 7) and alkaline conditions (pH = 10), and the subsequent heat treatment enhanced the stability of PDA–AgNPs nanocomposite coatings on porous titanium. The antibacterial test, cytotoxicity test, hypodermic implantation and osteogenesis test revealed that the homogeneous PDA–AgNPs nanocomposite coating achieved the balance between the antibacterial ability and cytocompatibility, and had the best outcomes for soft tissue healing and bone formation around the implants. This study provides a facile strategy for preparing silver-loaded surfaces with both good antibacterial effect and favorable cytocompatibility, which is expected to further improve the therapeutic efficacy of silver composite-coated dental implants.

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  • PDA itself actively regulates cellular behavior by stimulating osteoblast proliferation, osteogenic differentiation, and mineralized extracellular matrix formation.

    “Beyond this indirect effect, PDA itself actively regulates cellular behavior by stimulating osteoblast proliferation, osteogenic differentiation, and mineralized extracellular matrix formation.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [31]

    The Cytocompatibility section reports proliferation of osteoblast-like cells on the tested surfaces, and the in vivo implantation section reports greater new-bone formation with dopamine–silver coatings than with uncoated titanium (page numbers unavailable). These findings concern composite coatings, not PDA itself; the cited passages do not establish that PDA independently stimulates osteoblast proliferation, osteogenic differentiation, or mineralized extracellular matrix formation. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • PDA-AgNP composite coatings integrate the favorable biocompatibility of PDA with the potent broad-spectrum antibacterial activity of AgNPs, enabling sustained silver ion release for long-term suppression of oral pathogenic bacteria.

    “The resulting PDA–AgNP composite coatings integrate the favorable biocompatibility of PDA with the potent broad-spectrum antibacterial activity of AgNPs, enabling sustained silver ion release for long-term suppression of oral pathogenic bacteria.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [31]

    The Introduction describes broad-spectrum antibacterial activity of silver and proposes a PDA–silver coating that balances antibacterial effects with cytocompatibility. The Cytocompatibility section reports improved cell compatibility for the homogeneous coating, but also calls antibacterial surfaces a short-term measure whose effectiveness declines as the active substance is released. The antibacterial tests used Staphylococcus aureus; they do not establish sustained silver-ion release or long-term suppression of a range of oral pathogens. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • The presence of PDA mitigates the cytotoxic effects commonly associated with silver-based antibacterial systems.

    “Importantly, the presence of PDA mitigates the cytotoxic effects commonly associated with silver-based antibacterial systems.31,66,67”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [31]

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Cited by

Sorted by citations

Authors
Wang, S., Wu, Z., Wang, Y., Hong, H., Zhang, L., Chen, Z., Zhang, P., Chen, Z., Zhang, W., Zheng, S., Li, Q., Li, W., Li, X., Qiu, H., & Chen, J.
Affiliations
Anhui Medical University (CN)
Corresponding author
  • Li, Wei
  • Li, Xiangyang
  • Qiu, Hua
  • Chen, Jialong
ORCID
Venue
Regenerative Biomaterials
Publisher
Oxford University Press (OUP)
Published
2022-10-20
Volume
10
Pages
rbac082-rbac082
ISSN
  • 2056-3418 (ISSN-L)
  • 2056-3426
DOI
10.1093/rb/rbac082
PMC
PMC9847628
OpenAlex
W4306893542
Cited by
22
References
1
Citations by year
2026: 6 · 2025: 3 · 2024: 8 · 2023: 5
FWCI
1.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Regenerative Biomaterials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (31670967, 32000932, 82061160492)
  • Key Research and Development Projects in Anhui Province (202104j07020039, 2022e07020051)
  • Scientific Research Foundation of the Institute for Translational Medicine of Anhui Province (2021zhyx-C51, 2021zhyx-C68)
  • 2020 Disciplinary Construction Project in School of Dentistry, Anhui Medical University (2020kqkyT01, 2020kqkyT03, 2020kqsy09)
  • 2021 Disciplinary Construction Project in School of Dentistry, Anhui Medical University (2021kqxkFY13, 2021kqxkFY16)
  • Key Project of Natural Science Research of the Anhui Provincial Department of Education (KJ2019A0251, KJ2021A0270)
  • Anhui Provincial Natural Science Foundation (2208085QE136, 2008085QH374)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Keywords
dental implants, antibacterial coatings, cytocompatibility, silver nanoparticles, polydopamine, titanium implant surface modification, implant-associated infection, heat treatment, bone formation, soft tissue healing

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