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Cited by 15Intestinal and Peritoneal AdhesionsHydrogels: synthesis, properties, applicationsHernia repair and management

Evaluation of the effectiveness of alginate-based hydrogels in preventing peritoneal adhesions

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Meng, Zhu, Wang, Han, Liu, Yu, Yang, Minyi, Zeng, Hang, Han, Qianqian·2023·Regenerative Biomaterials
DOI 10.1093/rb/rbad017PMC PMC10110266
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Abstract

Infertility and intestinal blockage are just two examples of the postoperative consequences that can arise from peritoneal damage, which can also result in severe peritoneal fibrosis and peritoneal adhesions. Peritoneal adhesions are still not effectively treated, and both pharmaceutical therapy and biomaterial barriers have only had modest preventative effects. In this work, we looked into the effectiveness of in-place injectable sodium alginate hydrogel for peritoneal adhesion prevention. The findings demonstrated that sodium alginate hydrogel promoted human peritoneal mesothelial cell proliferation and migration, prevented peritoneal fibrosis by suppressing the production of transforming growth factor-β1, and, most importantly, promoted mesothelium self-repair. These findings imply that this brand-new sodium alginate hydrogel is a good candidate material for peritoneal adhesion prevention.

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  • Alginate-based hydrogels have been investigated for their potential to prevent post-surgical adhesions by creating a temporary physical barrier that separates injured tissues during healing.

    “In the context of anti-adhesion barriers, alginate-based hydrogels have been investigated for their potential to prevent post-surgical adhesions by creating a temporary physical barrier that separates injured tissues during the healing process [172,173].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [173]

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Cited by

Sorted by citations

Authors
Meng, Z., Wang, H., Liu, Y., Yang, M., Zeng, H., & Han, Q.
Affiliations
  • National Institutes for Food and Drug Control (CN)
  • Beijing Institute of Technology (CN)
  • Yantai University (CN)
  • China Pharmaceutical University (CN)
Corresponding author
Han, Qianqian
ORCID
Venue
Regenerative Biomaterials
Publisher
Oxford University Press (OUP)
Published
2023-01-01
Volume
10
Pages
rbad017-rbad017
ISSN
  • 2056-3418 (ISSN-L)
  • 2056-3426
DOI
10.1093/rb/rbad017
PMC
PMC10110266
OpenAlex
W4328052660
Cited by
15
References
0
Citations by year
2026: 5 · 2025: 4 · 2024: 5 · 2023: 1
FWCI
3.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Regenerative Biomaterials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National Key R&D Program of China (2022YFC2401800)
Topics
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Health Sciences › Medicine › Surgery › Hernia repair and management
Keywords
peritoneal adhesions, sodium alginate hydrogel, injectable hydrogel, peritoneal fibrosis, mesothelial cell proliferation, TGF-β1, adhesion prevention

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