CoChat
Sign Up
Cited by 23Carbon and Quantum Dots ApplicationsWound Healing and TreatmentsGraphene and Nanomaterials Applications

Constructing a highly efficient multifunctional carbon quantum dot platform for the treatment of infectious wounds

Open access
Zhang, Hangzhen, Bai, Jiafan, Chen, Xiangli, Wang, Linyu, Peng, Wenzhen, Zhao, Yuancong, Weng, Jie, Zhi, Wei +3 more·2024·Regenerative Biomaterials
DOI 10.1093/rb/rbae105PMC PMC11377098
Open this paper in CoChat — free account

Abstract

Antibiotic resistance poses a huge threat to public health, which has increased the difficulty and transmission of disease treatment, as well as the burden and cost of medical institutions. In response to the current problems and challenges in inflammation control and treatment of bacterial infected wounds, inspired by antibacterial mechanisms based on active elements such as N, S, Cu and tannic acid (TA), a highly efficient multifunctional carbon quantum dot platform was proposed in this study and constructed through their special assembly in a solvothermal reaction system for the treatment of infected wounds. By introducing active elements such as N, S and Cu, this carbon quantum dot platform is endowed with antibacterial properties, while also achieving good angiogenesis promoting performance through the use of ion Cu. Meanwhile, the good antioxidant activity of TA (one of the precursors used) enables this platform to have better immunomodulatory performance in vivo. The research results on the treatment of bacterial infection models indicate that the multifunctional carbon quantum dots obtained can accelerate the healing of infected wounds by inhibiting bacterial infection, regulating immunoreaction, accelerating collagen deposition and promoting angiogenesis. This multifunctional carbon quantum dot platform shows good clinical application prospects in treating bacterial infected wounds. Additionally, the fluorescence characteristics of such carbon dots can be expected to realize visual therapy in the future.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/rb/rbae105

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

No references could be resolved yet.

Research works printed but not linked: 63

  1. [1]Yu M, Li P, Huang R, Xu C, Zhang S, Wang Y, Gong X, Xing X. Antibacterial and antibiofilm mechanisms of carbon dots: a review. J Mater Chem B 2023; 11: 734– 54. 36602120
  2. [2]Chai S, Xie Y, Yang L. Antibacterial applications of elemental nanomaterials. Curr Opin Solid St M 2022; 26: 101043.
  3. [3]Cao D, Ding J. Recent advances in regenerative biomaterials. Regen Biomater 2022; 9: rbac098. 36518879 PMC9745784
  4. [4]Liu Y, Wang G, Luo H, Zhao B, Liao M, Dai Q, Li M, Li Q, Cao X. Phosphoserine enhanced Cu-doped bioactive glass dynamic dual-network hydrogel for craniofacial bone defect repair. Regen Biomater 2023; 10: rbad054. 37287897 PMC10243839
  5. [5]Hong X, Tian G, Zhu Y, Ren T. Exogeneous metal ions as therapeutic agents in cardiovascular disease and their delivery strategies. Regen Biomater 2024; 11: rbad103. 38173776 PMC10761210
  6. [6]Qi X, Huang Y, You S, Xiang Y, Cai E, Mao R, Pan W, Tong X, Dong W, Ye F, Shen J. Engineering robust Ag-decorated polydopamine nano-photothermal platforms to combat bacterial infection and prompt wound healing. Adv Sci (Weinh) 2022; 9: e2106015. 35191211 PMC9008420
  7. [7]Ma X, Wang L, Wang P, Liu Z, Hao J, Wu J, Chu G, Huang M, Mair L, Huang C, Xu T, Ying T, Tang X, Chen Y, Cai X, Zheng Y. An electromagnetically actuated magneto-nanozyme mediated synergistic therapy for destruction and eradication of biofilm. Chem Eng J 2022; 431: 133971.
  8. [8]Sun C, Wang X, Dai J, Ju Y. Metal and metal oxide nanomaterials for fighting planktonic bacteria and biofilms: a review emphasizing on mechanistic aspects. Int J Mol Sci 2022; 23: 11348. 36232647 PMC9569886
  9. [9]Li S, Su W, Wu H, Yuan T, Yuan C, Liu J, Deng G, Gao X, Chen Z, Bao Y, Yuan F, Zhou S, Tan H, Li Y, Li X, Fan L, Zhu J, Chen AT, Liu F, Zhou Y, Li M, Zhai X, Zhou J. Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids. Nat Biomed Eng 2020; 4: 704– 16. 32231314 PMC7197249
  10. [10]Li R, Wei F, Wu X, Zhou P, Chen Q, Cen Y, Xu G, Cheng X, Zhang A, Hu Q. PEI modified orange emissive carbon dots with excitation-independent fluorescence emission for cellular imaging and siRNA delivery. Carbon 2021; 177: 403– 11.
  11. [11]Zhao D, Li X, Xu M, Jiao Y, Liu H, Xiao X, Zhao H. Preparations of antibacterial yellow-green-fluorescent carbon dots and carbon dots-lysozyme complex and their applications in bacterial imaging and bacteria/biofilm inhibition/clearance. Int J Biol Macromol 2023; 231: 123303. 36657551
  12. [12]Xu Q, Li C, Meng X, Duo X, Feng Y. Polyethylenimine-modified graphene quantum dots promote endothelial cell proliferation. Regen Biomater 2024; 11: rbae013. 38525325 PMC10960926
  13. [13]Wu L, Yang Y, Huang L, Zhong Y, Chen Y, Gao Y, Lin L, Lei Y, Liu A. Levofloxacin-based carbon dots to enhance antibacterial activities and combat antibiotic resistance. Carbon 2022; 186: 452– 64.
  14. [14]Hajipour MJ, Fromm KM, Ashkarran AA, Jimenez de Aberasturi D, de Larramendi IR, Rojo T, Serpooshan V, Parak WJ, Mahmoudi M. Antibacterial properties of nanoparticles. Trends Biotechnol 2012; 30: 499– 511. 22884769
  15. [15]Wang H, Song Z, Gu J, Li S, Wu Y, Han H. Nitrogen-doped carbon quantum dots for preventing biofilm formation and eradicating drug-resistant bacteria infection. ACS Biomater Sci Eng 2019; 5: 4739– 49. 33448817
  16. [16]Gao Z, Yang D, Wan Y, Yang Y. One-step synthesis of carbon dots for selective bacterial inactivation and bacterial differentiation. Anal Bioanal Chem 2020; 412: 871– 80. 31901958
  17. [17]Mazumdar A, Haddad Y, Milosavljevic V, Michalkova H, Guran R, Bhowmick S, Moulick A. Peptide-carbon quantum dots conjugate, derived from human retinoic acid receptor responder protein 2, against antibiotic-resistant gram positive and gram negative pathogenic bacteria. Nanomaterials 2020; 10: 325. 32075033 PMC7075150
  18. [18]Jijie R, Barras A, Bouckaert J, Dumitrascu N, Szunerits S, Boukherroub R. Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects. Colloids Surf B Biointerfaces 2018; 170: 347– 54. 29940501
  19. [19]Romero MP, Alves F, Stringasci MD, Buzza HH, Ciol H, Inada NM, Bagnato VS. One-pot microwave-assisted synthesis of carbon dots and in vivo and in vitro antimicrobial photodynamic applications. Front Microbiol 2021; 12: 662149. 34234756 PMC8255795
  20. [20]Liu M, Huang L, Xu X, Wei X, Yang X, Li X, Wang B, Xu Y, Li L, Yang Z. Copper doped carbon dots for addressing bacterial biofilm formation, wound infection, and tooth staining. ACS Nano 2022; 16: 9479– 97. 35713471
  21. [21]Wang Y, Luo M, Li T, Xie C, Li S, Lei B. Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair. Bioact Mater 2023; 25: 319– 32. 36844363 PMC9946820
  22. [22]Guo Z, Xie W, Lu J, Guo X, Xu J, Xu W, Chi Y, Takuya N, Wu H, Zhao L. Tannic acid-based metal phenolic networks for bio-applications: a review. J Mater Chem B 2021; 9: 4098– 110. 33913461
  23. [23]Wu C, Zhou Z, You X, Guo Y, Chen P, Li H, Tong X. Tannic acid-loaded hydrogel coating endues polypropylene mesh with hemostatic and anti-inflammatory capacity for facilitating pelvic floor repair. Regen Biomater 2022; 9: rbac074. 36267152 PMC9575665
  24. [24]Chen B, Liu M, Li C, Huang C. Fluorescent carbon dots functionalization. Adv Colloid Interface Sci 2019; 270: 165– 90. 31265929
  25. [25]Varghese M, Balachandran M. Antibacterial efficiency of carbon dots against gram-positive and gram-negative bacteria: a review. J Environ Chem Eng 2021; 9: 106821.
  26. [26]Li J, Zhai D, Lv F, Yu Q, Ma H, Yin J, Yi Z, Liu M, Chang J, Wu C. Preparation of copper-containing bioactive glass/eggshell membrane nanocomposites for improving angiogenesis, antibacterial activity and wound healing. Acta Biomater 2016; 36: 254– 66. 26965395
  27. [27]Yu Q, Han Y, Wang X, Qin C, Zhai D, Yi Z, Chang J, Xiao Y, Wu C. Copper silicate hollow microspheres-incorporated scaffolds for chemo-photothermal therapy of melanoma and tissue healing. ACS Nano 2018; 12: 2695– 707. 29518321
  28. [28]Ding H, Ji Y, Wei J, Gao Q, Zhou Z, Xiong H. Facile synthesis of red-emitting carbon dots from pulp-free lemon juice for bioimaging. J Mater Chem B 2017; 5: 5272– 7. 32264113
  29. [29]Yuan F, Yuan T, Sui L, Wang Z, Xi Z, Li Y, Li X, Fan L, Tan Z, Chen A, Jin M, Yang S. Engineering triangular carbon quantum dots with unprecedented narrow bandwidth emission for multicolored LEDs. Nat Commun 2018; 9: 2249. 29884873 PMC5993800
  30. [30]Peng S, Wang C, Xie J, Sun S. Synthesis and stabilization of monodisperse Fe nanoparticles. J Am Chem Soc 2006; 128: 10676– 7. 16910651
  31. [31]Yang X, Guo Y, Liang S, Hou S, Chu T, Ma J, Chen X, Zhou J, Sun R. Preparation of sulfur-doped carbon quantum dots from lignin as a sensor to detect Sudan I in an acidic environment. J Mater Chem B 2020; 8: 10788– 96. 33156321
  32. [32]Salzer R. Peter R. Griffiths, James A. de Haseth: Fourier transform infrared spectrometry (2nd edn.). Anal Bioanal Chem 2008; 391: 2379– 80.
  33. [33]Wu W, Zhan L, Fan W, Song J, Li X, Li Z, Wang R, Zhang J, Zheng J, Wu M, Zeng H. Cu-N dopants boost electron transfer and photooxidation reactions of carbon dots. Angew Chem Int Ed Engl 2015; 54: 6540– 4. 25881689
  34. [34]Mu Z, Hua J, Feng S, Yang Y. A ratiometric fluorescence and light scattering sensing platform based on Cu-doped carbon dots for tryptophan and Fe(III). Spectrochim Acta A Mol Biomol Spectrosc 2019; 219: 248– 56. 31048254
  35. [35]Ding H, Wei J, Zhang P, Zhou Z, Gao Q, Xiong H. Solvent-controlled synthesis of highly luminescent carbon dots with a wide color gamut and narrowed emission peak widths. Small 2018; 14: e1800612. 29709104
  36. [36]Miao X, Qu D, Yang D, Nie B, Zhao Y, Fan H, Sun Z. Synthesis of carbon dots with multiple color emission by controlled graphitization and surface functionalization. Adv Mater 2018; 30: 1704740. 29178388
  37. [37]Ding H, Wei J, Xiong H. Nitrogen and sulfur co-doped carbon dots with strong blue luminescence. Nanoscale 2014; 6: 13817– 23. 25297983
  38. [38]Padhan S, Rout TK, Nair UG. N-doped and Cu,N-doped carbon dots as corrosion inhibitor for mild steel corrosion in acid medium. Colloids Surface A 2022; 653: 129905.
  39. [39]Sharma A, Gadly T, Gupta A, Ballal A, Ghosh SK, Kumbhakar M. Origin of excitation dependent fluorescence in carbon nanodots. J Phys Chem Lett 2016; 7: 3695– 702. 27588560
  40. [40]Qing W, Chen K, Yang Y, Wang Y, Liu X. Cu2+-doped carbon dots as fluorescence probe for specific recognition of Cr (VI) and its antimicrobial activity. Microchem J 2020; 152: 104262.
  41. [41]Zhu Y, Zhang J, Song J, Yang J, Xu T, Pan C, Zhang L. One-step synthesis of an antibacterial and pro-healing wound dressing that can treat wound infections. J Mater Chem B 2017; 5: 8451– 8. 32264512
  42. [42]Garcia CD, Ballester AM, Aliena VA, Caraben RA, Lloris JM. Use of cyanoacrylate adhesives in general surgery. Surg Today 2015; 45: 939– 56. 25344231
  43. [43]Archana D, Singh BK, Dutta J, Dutta PK. Chitosan-PVP-nano silver oxide wound dressing: in vitro and in vivo evaluation. Int J Biol Macromol 2015; 73: 49– 57. 25450048
  44. [44]Pedro AC, Paniz OG, Fernandes IAA, Bortolini DG, Rubio FTV, Haminiuk CWI, Maciel GM, Magalhaes WLE. The importance of antioxidant biomaterials in human health and technological innovation: a review. Antioxidants 2022; 11: 1644. 36139717 PMC9495759
  45. [45]Parham S, Kharazi AZ, Bakhsheshi-Rad HR, Nur H, Ismail AF, Sharif S, RamaKrishna S, Berto F. Antioxidant, antimicrobial and antiviral properties of herbal materials. Antioxidants 2020; 9: 1309. 33371338 PMC7767362
  46. [46]Andzi Barhé T, Feuya Tchouya GR. Comparative study of the anti-oxidant activity of the total polyphenols extracted from hibiscus sabdariffa L., Glycine max L. Merr., yellow tea and red wine through reaction with DPPH free radicals. Arabian J Chem 2016; 9: 1– 8.
  47. [47]Wei L, Li Q, Chen Y, Zhang J, Mi Y, Dong F, Lei C, Guo Z. Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts. Carbohydr Polym 2019; 206: 493– 503. 30553350
  48. [48]Garlea A, Melnig V, Popa MI. Nanostructured chitosan-surfactant matrices as polyphenols nanocapsules template with zero order release kinetics. J Mater Sci Mater Med 2010; 21: 1211– 23. 20033260
  49. [49]Iacopini P, Camangi F, Stefani A, Sebastiani L. Antiradical potential of ancient Italian apple varieties of malus×domestica borkh. in a peroxynitrite-induced oxidative process. J Food Compos Anal 2010; 23: 518– 24.
  50. [50]Qiu L, Wang C, Lan M, Guo Q, Du X, Zhou S, Cui P, Hong T, Jiang P, Wang J, Xia J. Antibacterial photodynamic gold nanoparticles for skin infection. ACS Appl Bio Mater 2021; 4: 3124– 32. 35014400
  51. [51]Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front Immunol 2014; 5: 614. 25506346 PMC4246889
  52. [52]Miao W, Zou W, Zhao Q, Wang Y, Chen X, Wu S, Liu Z, Xu T. Coupling room-temperature phosphorescence carbon dots onto active layer for highly efficient photodynamic antibacterial chemotherapy and enhanced membrane properties. J Membr Sci 2021; 639: 119754.
  53. [53]Yan H, Li P, Wen F, Xu Q, Guo Q, Su W. Green synthesis of carbon quantum dots from plant turmeric holds promise as novel photosensitizer for in vitro photodynamic antimicrobial activity. J Mater Res Technol 2023; 22: 17– 34.
  54. [54]Otis G, Bhattacharya S, Malka O, Kolusheva S, Bolel P, Porgador A, Jelinek R. Selective labeling and growth inhibition of Pseudomonas aeruginosa by aminoguanidine carbon dots. ACS Infect Dis 2019; 5: 292– 302. 30589261
  55. [55]Travlou NA, Giannakoudakis DA, Algarra M, Labella AM, Rodríguez-Castellón E, Bandosz TJ. S- and N-doped carbon quantum dots: surface chemistry dependent antibacterial activity. Carbon 2018; 135: 104– 11. 34996200
  56. [56]Xi J, Wei G, An L, Xu Z, Xu Z, Fan L, Gao L. Copper/carbon hybrid nanozyme: tuning catalytic activity by the copper state for antibacterial therapy. Nano Lett 2019; 20: 800– 54. 31808346
  57. [57]Chatterjee AK, Chakraborty R, Basu T. Mechanism of antibacterial activity of copper nanoparticles. Nanotechnology 2014; 25: 135101. 24584282
  58. [58]Nosrati H, Aramideh KR, Nosrati A, Khodaei M, Banitalebi DM, Ashrafi DK, Sanami S, Alizadeh Z. Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis. J Nanobiotechnol 2021; 19: 1. PMC7784275 33397416
  59. [59]Sheng L, Zhang Z, Zhang Y, Wang E, Ma B, Xu Q, Ma L, Zhang M, Pei G, Chang J. A novel “hot spring”-mimetic hydrogel with excellent angiogenic properties for chronic wound healing. Biomaterials 2021; 264: 120414. 32980635
  60. [60]Chen J, He J, Yang Y, Qiao L, Hu J, Zhang J, Guo B. Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing. Acta Biomater 2022; 146: 119– 30. 35483628
  61. [61]Wu C, Zhou Y, Xu M, Han P, Chen L, Chang J, Xiao Y. Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials 2013; 34: 422– 33. 23083929
  62. [62]Yang Y, Guo Z, Chen W, Wang X, Cao M, Han X, Zhang K, Teng B, Cao J, Wu W, Cao P, Huang C, Qiu Z. M2 macrophage-derived exosomes promote angiogenesis and growth of pancreatic ductal adenocarcinoma by targeting E2F2. Mol Ther 2021; 29: 1226– 38. 33221435 PMC7934635
  63. [63]Spiller KL, Nassiri S, Witherel CE, Anfang RR, Ng J, Nakazawa KR, Yu T, Vunjak NG. Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds. Biomaterials 2015; 37: 194– 207. 25453950 PMC4312192

Cited by

Sorted by citations

Authors
Zhang, H., Bai, J., Chen, X., Wang, L., Peng, W., Zhao, Y., Weng, J., Zhi, W., Wang, J., Zhang, K., & Zhang, X.
Affiliations
  • Southwest Jiaotong University (CN)
  • Key Laboratory of Advance Technologies of Materials, Ministry of Education, College of Medicine and School of Materials Science and Engineering, Southwest Jiaotong University , Chengdu 610031,
  • Sichuan University (CN)
Corresponding author
Wang, Jianxin
ORCID
Venue
Regenerative Biomaterials
Publisher
Oxford University Press (OUP)
Published
2024
Volume
11
Pages
rbae105-rbae105
ISSN
  • 2056-3418 (ISSN-L)
  • 2056-3426
DOI
10.1093/rb/rbae105
PMC
PMC11377098
OpenAlex
W4401836184
Cited by
23
References
0
Citations by year
2026: 15 · 2025: 7 · 2024: 1
FWCI
2.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Regenerative Biomaterials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Key Technologies R&D Program of China (2016YFC1102001)
  • Natural Science Foundation of Sichuan Province (2022NSFSC0369)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Carbon and Quantum Dots Applications
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
Keywords
carbon quantum dots, wound infection, antibacterial nanomaterials, tannic acid, copper, nitrogen and sulfur co-doping, angiogenesis, immunomodulation, antioxidant activity, collagen deposition, wound healing, antibiotic resistance, fluorescence imaging, solvothermal synthesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review