Poststreptococcal reactive arthritis: what is it and how do we know?
Abstract
Objective To find out whether poststreptococcal reactive arthritis (PSRA) is a discrete, homogeneous clinical syndrome. Method Literature review from case reports and case series. Results One hundred and eighty-eight cases were identified. The age distribution was bimodal, with one peak in childhood and one peak in adulthood. Eighty-three percent of streptococcal isolates were group A. The clinical presentation was heterogeneous but appeared different both from that of acute rheumatic fever (ARF) and from that of HLA B27-associated reactive arthritis. Carditis was rare. Conclusions The term PSRA encompasses significant heterogeneity. The link between the arthritis and the streptococcal infection is unproven.
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The literature describes a heterogeneous spectrum of PSRA without proven prognostic implications.
“so far literature describes a heterogeneous spectrum of PSRA without proven prognostic implications [18]”
From Differentiation of PSRA due to Group A and due to Nongroup A Streptococci in Patients with Early Arthritis and Elevated Antisteptolysin-O at Presentation (2009) · cites this paper as [18]
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Presence of D8/17 B-cell marker in patients with poststreptococcal reactive arthritis
Harel, L., Mukamel, M., Zeharia, A., Kodman, Y., Prais, D., Uziel, Y., Zabriskie, J. B., & Amir, J. (2007) · Rheumatology International · doi:10.1007/s00296-006-0296-z · Cited by 11 · see citing works
Jansen, T. L. T. A. (2009) · International Journal of Rheumatology · doi:10.1155/2009/286951
“Clinically, rheumatologists need to homogenize groups of PSRA patients as so far literature describes a heterogeneous spectrum of PSRA without proven prognostic implications [18].”
BackgroundInfluential
- Authors
- Mackie, S. L.
- Affiliations
- Northwick Park Hospital (GB)
- Corresponding author
- Mackie, S. L.
- ORCID
- Mackie, S. L.
- Venue
- Rheumatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-01
- Volume
- 43
- Issue
- 8
- Pages
- 949-954
- ISSN
- 0263-7103 (ISSN-L)
- 1460-2172
- OpenAlex
- W2117047626
- Cited by
- 128
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 1 · 2019: 7 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British journal of rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Keywords
- post-streptococcal reactive arthritis, Streptococcus pyogenes, acute rheumatic fever, HLA-B27, reactive arthritis, clinical heterogeneity, carditis, streptococcal infection, age distribution
- MeSH terms
- Adolescent, Adult, Anti-Infective Agents, Child, Child, Preschool, Female, HLA Antigens, Humans, Male, Middle Aged, Streptococcal Infections, Streptococcus pyogenes, Arthritis, Reactive, Age Distribution
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