MECHANISTIC MODELING PREDICTS NO SIGNIFICANT DOSE RATE EFFECT ON HEAVY-ION CARCINOGENESIS AT DOSE RATES RELEVANT FOR SPACE EXPLORATION

Heavy ion-induced carcinogenesis is a challenge for human space exploration, and mechanistically-motivated mathematical models are needed to predict space-relevant low dose-rate risks, which are difficult to measure experimentally, based on data at higher dose rates. We present such a model, whic…