Thirst and the state-dependent representation of incentive stimulus value in human motive circuitry
Open accessAbstract
Depletion imposes both need and desire to drink, and potentiates the response to need-relevant cues in the environment. The present fMRI study aimed to determine which neural structures selectively increase the incentive value of need-relevant stimuli in a thirst state. Towards this end, participants were scanned twice--either in a thirst or no-thirst state--while viewing pictures of beverages and chairs. As expected, thirst led to a selective increase in self-reported pleasantness and arousal by beverages. Increased responses to beverage when compared with chair stimuli were observed in the cingulate cortex, insular cortex and the amygdala in the thirst state, which were absent in the no-thirst condition. Enhancing the incentive value of need-relevant cues in a thirst state is a key mechanism for motivating drinking behavior. Overall, distributed regions of the motive circuitry, which are also implicated in salience processing, craving and interoception, provide a dynamic body-state dependent representation of stimulus value.
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The interoceptive network has multiple connections to the amygdala, hypothalamus, hippocampus, and brainstem.
“This network also presents multiple connections to the amygdala, hypothalamus, hippocampus, and brainstem (Craig, 2009; Becker et al., 2015; Kleint et al., 2015; Khalsa et al., 2018).”
From Mindfulness, Interoception, and the Body: A Contemporary Perspective (2019) · cites this paper as Becker et al., 2015
The section “Saliency: a neural network perspective” describes functional connectivity between the MCC and anterior insula, but does not describe connections from an interoceptive network to the four regions named in the claim. Searches for those regions and their connectivity found no passage in our copy establishing the claimed connections. (LLM, conf=0.72)
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References 73 · Cited by 30
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- Authors
- Becker, C. A., Schmälzle, R., Flaisch, T., Renner, B., & Schupp, H. T.
- Affiliations
- University of Konstanz (DE)
- Venue
- Social Cognitive and Affective Neuroscience
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-05-13
- Volume
- 10
- Issue
- 12
- Pages
- 1722-1729
- ISSN
- 1749-5016 (ISSN-L)
- 1749-5024
- PMC
- PMC4666113
- OpenAlex
- W2146833202
- Cited by
- 30
- References
- 73
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 4 · 2017: 5 · 2016: 1 · 2015: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Social Cognitive and Affective Neuroscience (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- KOPS (University of Konstanz) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (RE 3430)
- Bundesministerium für Bildung und Forschung (RE 3430, 0315671)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- thirst, incentive value, bodily states, drinking motives, cingulate cortex, insula, amygdala, salience processing, craving, interoception
- MeSH terms
- Adult, Amygdala, Arousal, Beverages, Brain Mapping, Cerebral Cortex, Cues, Drinking Behavior, Female, Humans, Magnetic Resonance Imaging, Male, Motivation, Nerve Net, Thirst, Young Adult
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