The Dopamine Hypothesis of Schizophrenia: A Review*
Abstract
Herbert Y. Meltzer, M.D., Stephen M. Stahl, M.D.; The Dopamine Hypothesis of Schizophrenia: A Review*, Schizophrenia Bulletin, Volume 2, Issue 1, 1 January 1976
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The DA hypothesis of schizophrenia suggests that excess DA transmission may be pro-psychotic, and originally gained support from pharmacological evidence that drugs decreasing DA activity are antipsychotic whereas drugs promoting DA activity are psychotomimetic.
“The DA hypothesis of schizophrenia suggests that excess DA transmission may be pro-psychotic, and originally gained support from pharmacological evidence that drugs that decrease DA activity (for example,, the phenothiazine neuroleptics) are antipsychotic, whereas drugs that promote DA activity (for example,, amphetamines) are psychotomimetic [76,357].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [357]
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References 377 · Cited by 883
- Authors
- Meltzer, H. Y., & Stahl, S. M.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Meltzer, H. Y.
- ORCID
- Stahl, S. M.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1976-01-01
- Volume
- 2
- Issue
- 1
- Pages
- 19-76
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2162836351
- Cited by
- 883
- References
- 377
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 24 · 2023: 27 · 2022: 17 · 2021: 20 · 2020: 17 · 2019: 12 · 2018: 10 · 2017: 17 · 2016: 14 · 2015: 17 · 2014: 17 · 2013: 24 · 2012: 23
- FWCI
- 25.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- dopamine hypothesis, schizophrenia
- MeSH terms
- Behavior, Brain, Cerebral Cortex, Corpus Striatum, Dopamine, Humans, Hypothalamus, Limbic System, Median Eminence, Mesencephalon, Neuromuscular Diseases, Neurons, Receptors, Drug, Retina, Schizophrenia, Stress, Psychological, Substantia Nigra, Telencephalon, Thalamus, Tranquilizing Agents, Dopamine Antagonists
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