The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Beyond the Usual Suspects: Positive Attitudes Towards Positive Symptoms Is Associated With Medication Noncompliance in Psychosis
Open accessAbstract
Antipsychotic medication represents the treatment of choice in psychosis according to clinical guidelines. Nevertheless, studies show that half to almost three-quarter of all patients discontinue medication with antipsychotics after some time, a fact which is traditionally ascribed to side-effects, mistrust against the clinician and poor illness insight. The present study investigated whether positive attitudes toward psychotic symptoms (ie, gain from illness) represent a further factor for medication noncompliance. An anonymous online survey was set up in order to prevent conservative response biases that likely emerge in a clinical setting. Following an iterative selection process, data from a total of 113 patients with a likely diagnosis of schizophrenia and a history of antipsychotic treatment were retained for the final analyses (80%). While side-effect profile and mistrust emerged as the most frequent reasons for drug discontinuation, 28% of the sample reported gain from illness (eg, missing voices, feeling of power) as a motive for noncompliance. At least every fourth patient reported the following reasons: stigma (31%), mistrust against the physician/therapist (31%), and rejection of medication in general (28%). Approximately every fifth patient had discontinued antipsychotic treatment because of forgetfulness. On average, patients provided 4 different explanations for noncompliance. Ambivalence toward symptoms and treatment should thoroughly be considered when planning treatment in psychosis. While antipsychotic medication represents the evidence-based cornerstone of the current treatment in schizophrenia, further research is needed on nonpharmacological interventions for noncompliant patients who are willing to undergo intervention but refuse pharmacotherapy.
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In the citing paper
“Patients’ non-adherence to their psychotropic medication was associated with some non-modifiable demographic factors such as age and gender) [28].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [28]
In the citing paper
“In eight studies, the perception or the feeling of psychiatric patients being stigmatized by their families, neighbors, health professionals, and other community members was a factor associated with medication non-adherence [24, 25, 28, 36, 37, 41, 45, 65].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [28]
In the citing paper
“In several studies, psychotropic medication non-adherence was associated with medication-related side-effects [11, 22–25, 28–30, 32–37, 39, 44, 50, 52, 55, 64, 65].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [28]
In the citing paper
“In the worst scenario, patients’ complete rejection of the medication was a main cause of discontinuation and non-adherence to their medication [28].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [28]
In the citing paper
“In seven studies, patients’ lack of insight (level of awareness or understanding) about their illness and medication was a common factor associated with psychotropic medication non-adherence [21, 23, 28, 39, 40, 50, 51].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [28]
In the citing paper
“Another two studies, feeling of powerlessness, insomnia, difficulty thinking or concentrating, restlessness, or feeling jittery were found to be associated with medication non-adherence [28, 37].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [28]
In the citing paper
“Medication non-adherence was affected by the number of hospitalizations [28], irregular hospitalization and frequently discharge of patients, length of stay [42, 46], lack of patients’ satisfaction with health care services [44], and long distance to access the health service/recollect medications [50].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [28]
In the citing paper
“Consequently, unfriendly, judgmental behavior, inflexible appointment systems, mistrust, and having negative patient-physician relationships were the factors associated with patients’ psychotropic mediation non-adherence [28, 30, 60].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [28]
Citations
Cites
Kahn, R. S., Fleischhacker, W. W., Boter, H., Davidson, M., Vergouwe, Y., Keet, I. P., Gheorghe, M. D., Rybakowski, J. K., Galderisi, S., Libiger, J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60486-9 · Cited by 1,088
Evidence that three dimensions of psychosis have a distribution in the general population
Stefanis, N. C., Hanssen, M., SMIRNIS, N. K., Avramopoulos, D., Evdokimidis, I., Stefanis, C., Verdoux, H., & van Os, J. (2002) · Psychological Medicine · doi:10.1017/s0033291701005141 · Cited by 945
Chadwick, P., & Birchwood, M. J. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.2.190 · Cited by 807
A self‐report Insight Scale for psychosis: reliability, validity and sensitivity to change
Birchwood, M. J., Smith, J., Drury, V., Healy, J., Macmillan, F., & Slade, M. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb01487.x · Cited by 695
Textbook of psychopharmacology
Edwards, G. (1975) · Nature · doi:10.1038/258648b0 · Cited by 583
Leucht, S., Arbter, D., Engel, R. R., Kissling, W., & Davis, J. M. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002136 · Cited by 489
Drug Refusal in Schizophrenia and the Wish to Be Crazy
Putten, T. V. (1976) · Archives of General Psychiatry · doi:10.1001/archpsyc.1976.01770120047004 · Cited by 259
Public attitude towards psychiatric treatment
Angermeyer, M. C., & Matschinger, H. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb09868.x · Cited by 228
The Omnipotence of Voices II: the Beliefs About Voices Questionnaire (BAVQ)
Chadwick, P., & Birchwood, M. J. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.166.6.773 · Cited by 203
Antipsychotic Medication Adherence in Schizophrenia
Byerly, M., Nakonezny, P. A., & Lescouflair, E. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2007.04.002 · Cited by 177
Cognitive and emotional predictors of predisposition to hallucinations in non‐patients
Morrison, A. P., Adrian Wells, A., & Nothard, S. (2002) · British Journal of Clinical Psychology · doi:10.1348/014466502760379127 · Cited by 174
Self-citationPatients' attitudes toward hallucinations
Miller, L. J., O'Connor, E., & DiPasquale, T. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.4.584 · Cited by 116
Karow, A., Czekalla, J., Dittmann, R., Schacht, A., Wagner, T., Lambert, M., SCHIMMELMANN, B. G., & Naber, D. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0110 · Cited by 116
Self-citationMorrison, A. P., Nothard, S., Bowe, S. E., & Adrian Wells, A. (2003) · Behaviour Research and Therapy · doi:10.1016/j.brat.2003.08.009 · Cited by 97
Self-citationCharacteristics of Patients with Schizophrenia Who Do Not Believe They Are Mentally Ill
Pyne, J. M., Bean, D. L., & Sullivan, G. (2001) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200103000-00002 · Cited by 88
Brett, C., Johns, L., PETERS, E. R., & McGuire, P. K. (2008) · Psychological Medicine · doi:10.1017/s0033291708004650 · Cited by 87
Measuring outcome priorities and preferences in people with schizophrenia
Rosenheck, R. A., Stroup, T. S., Keefe, R. S. E., McEvoy, J. M., Swartz, M. S., Perkins, D. O., Hsiao, J., Shumway, M., & Lieberman, J. A. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.187.6.529 · Cited by 81
Morrison, A. P., Hutton, P., Wardle, M., Spencer, H. M., Barratt, S., Brabban, A., Callcott, P., Christodoulides, T., Dudley, R. E. J., French, P., et al. (2011) · Psychological Medicine · doi:10.1017/s0033291711001899 · Cited by 78
Self-citationPleasurable auditory hallucinations
Sanjuán, J., González, J. C., Aguilar, E. J., Leal, C., & van Os, J. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2004.00336.x · Cited by 75
Harrow, M., & Jobe, T. H. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn074 · Cited by 72
Kurtz, M. M., Baker, E., Pearlson, G. D., & Astur, R. S. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl039 · Cited by 71
Jenner, J. A., Rutten, S., Beuckens, J., Boonstra, N., & Sytema, S. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01226.x · Cited by 69
SUBJECTIVE ILLNESS THEORY AND ANTIPSYCHOTIC MEDICATION COMPLIANCE BY PATIENTS WITH SCHIZOPHRENIA
Holzinger, A., Löffler, W., MÜLLER, P., Priebe, S., & Angermeyer, M. C. (2002) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200209000-00004 · Cited by 67
Subjective illness theory and antipsychotic medication compliance by patients with schizophrenia.
Holzinger, A., Löffler, W., Muller, P., et al. (2002) · PubMed · doi:10.1097/01.nmd.0000030524.45210.fd · Cited by 58
Moritz, S., Hocaoglu, C., Karow, A., Deljković, A., Tonn, P., & Naber, D. (2009) · Mental Illness · doi:10.4081/mi.2009.e2 · Cited by 58
Self-citationMorrison, A. P., Gumley, A. I., Schwannauer, M., Campbell, M., Gleeson, A., Griffin, E., & Gillan, K. (2004) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465804001900 · Cited by 58
Self-citationJones, S. H., Guy, A., & Ormrod, J. A. (2003) · Psychology and Psychotherapy Theory Research and Practice · doi:10.1348/147608303765951212 · Cited by 57
Schäfer, I., & Fisher, H. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32834b56c8 · Cited by 56
Correlates of the Affective Impact of Auditory Hallucinations in Psychotic Disorders
Copolov, D., Mackinnon, A. J., & Trauer, T. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007060 · Cited by 55
Morrison, A. P., Gumley, A. I., Ashcroft, K., Manousos, I. R., White, R. G., Gillan, K., Adrian Wells, A., & Kingdon, D. (2010) · British Journal of Clinical Psychology · doi:10.1348/014466510x511141 · Cited by 53
Self-citationBenevolent Voices Are Not So Kind: The Functional Significance of Auditory Hallucinations
Favrod, J., Grasset, F., Spreng, S., Grossenbacher, B., & Hodé, Y. (2004) · Psychopathology · doi:10.1159/000082269 · Cited by 46
Self-citationKlapheck, K., Nordmeyer, S., Cronjäger, H., Naber, D., & Bock, T. A. (2011) · Psychological Medicine · doi:10.1017/s0033291711001103 · Cited by 34
Lenzi, A., Lazzerini, F., PLACIDI, G.-F., Cassano, G. B., & Akiskal, H. (1989) · Pharmacopsychiatry · doi:10.1055/s-2007-1014574 · Cited by 25
Lepage, M., Bodnar, M. D., Joober, R., & MALLA, A. K. (2010) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2010.00174.x · Cited by 22
Lambert, M., & Naber, D. (2009) · doi:10.1007/978-1-907673-38-2 · Cited by 14
Subjective Experience of Schizophrenia*
Wadeson, H., & Carpenter, W. T. (1976) · Schizophrenia Bulletin · doi:10.1093/schbul/2.2.302 · Cited by 10
Woo, T.-U. W., Canuso, C. M., Wojcik, J., Brunette, M. F., & Green, A. I. (2009) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585623860.as55 · Cited by 8
Research works printed but not linked: 1
- Chadwick, 1996, Cognitive therapy for voices, 71
Cited by
Sorted by citations
Semahegn, A., Torpey, K., Manu, A., Assefa, N., Tesfaye, G., & Ankomah, A. (2020) · Systematic Reviews · doi:10.1186/s13643-020-1274-3 · Cited by 555
Georgiou, N., Delfabbro, P., & Balzan, R. P. (2020) · Personality and Individual Differences · doi:10.1016/j.paid.2020.110201 · Cited by 291
Self-disorders and Schizophrenia: A Phenomenological Reappraisal of Poor Insight and Noncompliance
Henriksen, M. G., & Parnas, J. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt087 · Cited by 154
Japanese Society of Neuropsychopharmacology (2021) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12193 · Cited by 105
Moritz, S., Pfuhl, G., Lüdtke, T., Menon, M., Balzan, R. P., & Andreou, C. (2016) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2016.07.004 · Cited by 99
Self-citation
Metadata
- Authors
- Moritz, S., Favrod, J., Andreou, C., Morrison, A. P., Bohn, F., Veckenstedt, R., Tonn, P., & Karow, A.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- University of Manchester (GB)
- Corresponding author
- Moritz, Steffen
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-02-15
- Volume
- 39
- Issue
- 4
- Pages
- 917-922
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC3686441
- OpenAlex
- W2097580073
- Cited by
- 112
- References
- 37
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 14 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 13 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 3
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- medication non-adherence, psychosis
- MeSH terms
- Adult, Attitude to Health, Female, Humans, Male, Middle Aged, Psychotic Disorders, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Logistic Models, Medication Adherence
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