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Acute, Subchronic and Withdrawal Sleep EEG Changes During Treatment With Paroxetine and Amitriptyline: A Double-Blind Randomized Trial in Major Depression
Abstract
Paroxetine (30 mg), a selective serotonin (5-HT) reuptake inhibitor, was compared in a double-blind trial to amitriptyline (150 mg) in a sample of 40 inpatients aged 18-65 years who fulfilled Research Diagnostic Criteria for major depression. Patients were studied after a placebo drug washout period of 10 days and after an active 4-week treatment period. Sleep EEG recordings were performed before and at the end of the study as well as during acute treatment (first 2 days) and following withdrawal of active medication. Paroxetine shows an antidepressant effect similar to amitriptyline with a different side-effect profile typical of 5-HT reuptake inhibition. Paroxetine and amitriptyline decreased the amount of REM sleep, a well-known effect of classical antidepressants. Paroxetine also shared with other 5-HT reuptake inhibitors an alerting effect on sleep that was not shown to be detrimental on subjective sleep quality.
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Amitriptyline (150mg) produced more alerting effects than paroxetine (30mg) in depressed patients.
“(Staner et al., 1995) found that amitriptyline (150mg) produced more alerting effects than paroxetine (30mg).”
From Antidepressants and their effect on sleep (2005) · cites this paper as Staner et al., 1995
Paroxetine (30mg) was more alerting than amitriptyline (150mg).
“(Staner et al., 1995) showed that paroxetine (30mg) was more alerting than amitriptyline (150mg).”
From Antidepressants and their effect on sleep (2005) · cites this paper as Staner et al., 1995
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Winokur, A., Gary, K. A., Rodner, S., Rae-Red, C., Fernando, A. T., & Szuba, M. P. (2001) · Depression and Anxiety · doi:10.1002/da.1043 · Cited by 179
Hotopf, M., Lewis, G., & Normand, C. (1997) · Journal of Epidemiology and Community Health · doi:10.1136/jech.51.4.354 · Cited by 130
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Metadata
- Authors
- Staner, L., Kerkhofs, M., Detroux, D., Leyman, S., Linkowski, P., & Mendlewicz, J.
- Affiliations
- Université Libre de Bruxelles (BE)
- GlaxoSmithKline (Belgium) (BE)
- Corresponding author
- Luc Staner
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-08-01
- Volume
- 18
- Issue
- 6
- Pages
- 470-7
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W204785327
- Cited by
- 90
- References
- 0
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2012: 2
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- paroxetine, amitriptyline, major depressive disorder, sleep EEG, REM sleep, selective serotonin reuptake inhibitors, tricyclic antidepressants, antidepressant discontinuation, sleep quality, antidepressant side effects
- MeSH terms
- Adolescent, Adult, Aged, Amitriptyline, Antidepressive Agents, Depressive Disorder, Double-Blind Method, Electroencephalography, Humans, Male, Middle Aged, Sleep Stages, Sleep, REM, Wakefulness, Polysomnography, Selective Serotonin Reuptake Inhibitors, Paroxetine
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