CoChat
Sign Up
Cited by 3Animal health and immunologyMicrobial infections and disease researchAnimal Behavior and Welfare Studies

The effects of pretransportation or arrival meloxicam administration to calves entering the feedlot on morbidity, biomarkers, performance, and carcass characteristics

Open access
Van Engen, Nicholas K, Engelken, Terry J, Lockard, Caleb G, Lakritz, Jeffery, Cernicchiaro, Natalia, Wilson, Blake K, Krehbiel, Clint R, Coetzee, Johann F·2019·Translational Animal Science
DOI 10.1093/tas/txz070PMC PMC7200945
Open this paper in CoChat — free accountOpen PDF

Abstract

The objective of this trial was to investigate the effects of using meloxicam as a pretransport or on arrival therapeutic on disease outcomes of bovine respiratory disease (BRD), biomarker outcomes associated with BRD, performance characteristics over the first 42 d on feed, and carcass traits at harvest in cross bred beef cattle. Multisourced, crossbred steer calves (n = 168) consisting of mainly British and British-Continental breeds were purchased from an auction market in central Missouri. Calves were processed prior to transportation and again upon feedlot arrival. Animals were randomized to 3 separate treatments: pretransport meloxicam (PMEL), arrival meloxicam (AMEL), and a control group receiving inactive excipient (CONT). Dosing at 1 mg/kg on weighted averaged administered per os. Animals were weighed and blood was collected pre- and post-transport. Haptoglobin (Hp)-matrix metaloproteinase (MMP)-9 complex, cortisol, and substance P were quantified. Weights were taken again at 42 d and at harvest. Clinical signs of BRD were monitored using indicators of depression, appetite, respiration, and temperature that qualified the animals for treatment. Harvest parameters were collected using a standardized United States Department of Agriculture grading system for quality grade and yield grade. Meloxicam did not have a significant effect on BRD morbidity over the course of the study and there was no significant effect on performance characteristics at 42 d (P > 0.10). Of the calves that did succumb to BRD, no significant differences were found in severity of disease (P > 0.10). Concentrations of substance P and Hp- MMP-9, were increased on arrival (P ≤ 0.05) however no significant treatment effect or interaction were found between AMEL, PMEL, CONT, or across different levels of biomarkers (P > 0.10). Meloxicam use prior to or on arrival does not mitigate disease or improve performance during the feeding period.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/tas/txz070

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 40

  1. Ackermann M. R., Derscheid R., and Roth J. A. 2010 Innate immunology of bovine respiratory disease. Vet. Clin. North Am. Food Anim. Pract. 26: 215– 228. doi: 10.1016/j.cvfa.2010.03.001. 20619180 PMC2904317 · DOI
  2. Arthington J. D., Eichert S. D., Kunkle W. E., and Martin F. G. 2003 Effect of transportation and commingling on the acute-phase protein response, growth, and feed intake of newly weaned beef calves. J. Anim. Sci. 81: 1120– 1125. doi: 10.2527/2003.8151120x. 12772837 · DOI · Paper page
  3. Carpenter A. J., Ylioja C. M., Vargas C. F., Mamedova L. K., Mendonça L. G., Coetzee J. F., Hollis L. C., Gehring R., and Bradford B. J. 2016 Hot topic: Early postpartum treatment of commercial dairy cows with nonsteroidal antiinflammatory drugs increases whole-lactation milk yield. J. Dairy Sci. 99: 672– 679. doi: 10.3168/jds.2015-10048. 26519977 · DOI
  4. Carroll J. A., Arthington J. D., and Chase C. C. Jr 2009 Early weaning alters the acute-phase reaction to an endotoxin challenge in beef calves. J. Anim. Sci. 87: 4167– 4172. doi: 10.2527/jas.2009-2016. 19717781 · DOI
  5. Caswell J. L 2014 Failure of respiratory defenses in the pathogenesis of bacterial pneumonia of cattle. Vet. Pathol. 51: 393– 409. doi: 10.1177/0300985813502821. 24021557 · DOI
  6. Cernicchiaro N., White B. J., Renter D. G., Babcock A. H., Kelly L., and Slattery R. 2012 Associations between the distance traveled from sale barns to commercial feedlots in the United States and overall performance, risk of respiratory disease, and cumulative mortality in feeder cattle during 1997 to 2009. J. Anim. Sci. 90: 1929– 1939. doi: 10.2527/jas.2011-4599. 22247119 · DOI
  7. Chacon G., Garcia-Belenguer S., Villarroel M., and Maria G. A. 2005 Effect of transport stress on physiological responses of male bovines. Dtsch. Tierarztl. Wochenschr. 112: 465– 469. 16425633
  8. Coetzee J. F., Lubbers B. V., Toerber S. E., Gehring R., Thomson D. U., White B. J., and Apley M. D. 2008 Plasma concentrations of substance P and cortisol in beef calves after castration or simulated castration. Am. J. Vet. Res. 69: 751– 762. doi: 10.2460/ajvr.69.6.751. 18518655 · DOI
  9. Coetzee J. F., Edwards L. N., Mosher R. A., Bello N. M., O’Connor A. M., Wang B., Kukanich B., and Blasi D. A. 2012a Effect of oral meloxicam on health and performance of beef steers relative to bulls castrated on arrival at the feedlot. J. Anim. Sci. 90: 1026– 1039. doi: 10.2527/jas.2011-4068. 21965454 · DOI
  10. Coetzee J. F., Mosher R. A., KuKanich B., Gehring R., Robert B., Reinbold J. B., and White B. J. 2012b Pharmacokinetics and effect of intravenous meloxicam in weaned holstein calves following scoop dehorning without local anesthesia. BMC Vet. Res. 8: 153. doi: 10.1186/1746-6148-8-153. 22937949 PMC3503738 · DOI
  11. Coetzee J. F., Mosher R. A., Griffith G. R., Gehring R., Anderson D. E., KuKanich B., and Miesner M. 2015 Pharmacokinetics and tissue disposition of meloxicam in beef calves after repeated oral administration. J. Vet. Pharmacol. Ther. 38: 556– 562. doi: 10.1111/jvp.12215. 25708937 · DOI
  12. Cooke R. F., Cappellozza B. I., Guarnieri Filho T. A., and Bohnert D. W. 2013a Effects of flunixin meglumine administration on physiological and performance responses of transported feeder cattle. J. Anim. Sci. 91: 5500– 5506. doi: 10.2527/jas.2013-6336. 24045487 · DOI
  13. Cooke R. F., Guarnieri Filho T. A., Cappellozza B. I., and Bohnert D. W. 2013b Rest stops during road transport: Impacts on performance and acute-phase protein responses of feeder cattle. J. Anim. Sci. 91: 5448– 5454. doi: 10.2527/jas.2013-6357. 23989870 · DOI
  14. DeVane C. L 2001 Substance P: A new era, a new role. Pharmacotherapy 21: 1061– 1069. 11560196
  15. Edwards T. A 2010 Control methods for bovine respiratory disease for feedlot cattle. Vet. Clin. North Am. Food Anim. Pract. 26: 273– 284. doi: 10.1016/j.cvfa.2010.03.005. 20619184 · DOI
  16. Friton G. M., Cajal C., and Ramirez-Romero R. 2005 Long-term effects of meloxicam in the treatment of respiratory disease in fattening cattle. Vet. Rec. 156: 809– 811. 15965005
  17. Friton G. M., Cajal C., Ramirez Romero R., and Kleemann R. 2004 Clinical efficacy of meloxicam (metacam) and flunixin (finadyne) as adjuncts to antibacterial treatment of respiratory disease in fattening cattle. Berl. Munch. Tierarztl. Wochenschr. 117: 304– 309. 15298058
  18. Gifford C. A., Holland B. P., Mills R. L., Maxwell C. L., Farney J. K., Terrill S. J., Step D. L., Richards C. J., Burciaga Robles L. O., and Krehbiel C. R. 2012 Growth and development symposium: Impacts of inflammation on cattle growth and carcass merit. J. Anim. Sci. 90: 1438– 1451. doi: 10.2527/jas.2011-4846. 22573836 · DOI
  19. Gorsich E. E., Luis A. D., Buhnerkempe M. G., Grear D. A., Portacci K., Miller R. S., and Webb C. T. 2016 Mapping U.S. Cattle shipment networks: Spatial and temporal patterns of trade communities from 2009 to 2011. Prev. Vet. Med. 134: 82– 91. doi: 10.1016/j.prevetmed.2016.09.023. 27836049 · DOI
  20. Guarnieri Filho T. A., Cooke R. F., Cappellozza B. I., Reis M. M., Marques R. S., and Bohnert D. W. 2014 Effects of meloxicam administration on physiological and performance responses of transported feeder cattle. J. Anim. Sci. 92: 4137– 4144. doi: 10.2527/jas.2014-7783. 25023798 · DOI
  21. Hanthorn C. J., Dewell G. A., Dewell R. D., Cooper V. L., Wang C., Plummer P. J., and Lakritz J. 2014 Serum concentrations of haptoglobin and haptoglobin-matrix metalloproteinase 9 (hp-MMP 9) complexes of bovine calves in a bacterial respiratory challenge model. BMC Vet. Res. 10: 285. doi: 10.1186/s12917-014-0285-5. 25480520 PMC4263037 · DOI
  22. Hinds C. A., Niehaus A. J., Premanandan C., Rajala-Schultz P. J., Rings D. M., and Lakritz J. 2014 Characterization of the contributions of hp-MMP 9 to the serum acute phase protein response of lipopolysaccharide challenged calves. BMC Vet. Res. 10: 261. doi: 10.1186/s12917-014-0261-0. 25358728 PMC4220046 · DOI
  23. Holland B. P., Step D. L., Burciaga-Robles L. O., Fulton R. W., Confer A. W., Rose T. K., Laidig L. E., Richards C. J., and Krehbiel C. R. 2011 Effectiveness of sorting calves with high risk of developing bovine respiratory disease on the basis of serum haptoglobin concentration at the time of arrival at a feedlot. Am. J. Vet. Res. 72: 1349– 1360. doi: 10.2460/ajvr.72.10.1349. 21962278 · DOI
  24. Lockwood P. W., Johnson J. C., and Katz T. L. 2003 Clinical efficacy of flunixin, carprofen and ketoprofen as adjuncts to the antibacterial treatment of bovine respiratory disease. Vet. Rec. 152: 392– 394. 12696705
  25. Marti S., Wilde R. E., Moya D., Heuston C. E., Brown F., and Schwartzkopf-Genswein K. S. 2017 Effect of rest stop duration during long-distance transport on welfare indicators in recently weaned beef calves. J. Anim. Sci. 95: 636– 644. doi: 10.2527/jas.2016.0739. 28380612 · DOI
  26. Meléndez D. M., Marti S., Pajor E. A., Moya D., Gellatly D., Janzen E. D., and Schwartzkopf-Genswein K. S. 2018 Effect of a single dose of meloxicam prior to band or knife castration in 1-wk-old beef calves: I. Acute pain. J. Anim. Sci. 96: 1268– 1280. doi: 10.1093/jas/sky034. 29506258 PMC6140982 · DOI
  27. Nagel D., Wieringa R., Ireland J., and Olson M. E. 2016 The use of meloxicam oral suspension to treat musculoskeletal lameness in cattle. Vet. Med. (Auckl). 7: 149– 155. doi: 10.2147/VMRR.S112200. 30050847 PMC6044795 · DOI
  28. Nutrient Requirement of Beef Cattle 2014 Chapter 20: Table for nutrient requirements of beef cattle. 8th rev. ed. Washington (DC): The National Academies Press p. 396– 397
  29. Perino L. J., Wittum T. E., and Ross G. S. 1995 Effects of various risk factors on plasma protein and serum immunoglobulin concentrations of calves at postpartum hours 10 and 24. Am. J. Vet. Res. 56: 1144– 1148. 7486390
  30. Plumb D. C. 2015 Plumb’s Vet. Drug Handbook. 8th edn. Hoboken (NJ): Wiley-Blackwell.
  31. Senthilkumaran C., Clark M. E., Abdelaziz K., Bateman K. G., MacKay A., Hewson J., and Caswell J. L. 2013 Increased annexin A1 and A2 levels in bronchoalveolar lavage fluid are associated with resistance to respiratory disease in beef calves. Vet. Res. 44: 24. doi: 10.1186/1297-9716-44-24. 23565988 PMC3635868 · DOI
  32. Slocombe R. F., Malark J., Ingersoll R., Derksen F. J., and Robinson N. E. 1985 Importance of neutrophils in the pathogenesis of acute pneumonic pasteurellosis in calves. Am. J. Vet. Res. 46: 2253– 2258. 4073635
  33. Step D. L., Krehbiel C. R., DePra H. A., Cranston J. J., Fulton R. W., Kirkpatrick J. G., Gill D. R., Payton M. E., Montelongo M. A., and Confer A. W. 2008 Effects of commingling beef calves from different sources and weaning protocols during a forty-two-day receiving period on performance and bovine respiratory disease. J. Anim. Sci. 86: 3146– 3158. doi: 10.2527/jas.2008-0883. 18567723 · DOI
  34. Tennant T. C., Ives S. E., Harper L. B., Renter D. G., and Lawrence T. E. 2014 Comparison of tulathromycin and tilmicosin on the prevalence and severity of bovine respiratory disease in feedlot cattle in association with feedlot performance, carcass characteristics, and economic factors. J. Anim. Sci. 92: 5203– 5213. doi: 10.2527/jas.2014-7814. 25349362 · DOI
  35. Theurer M. E., White B. J., Coetzee J. F., Edwards L. N., Mosher R. A., and Cull C. A. 2012 Assessment of behavioral changes associated with oral meloxicam administration at time of dehorning in calves using a remote triangulation device and accelerometers. BMC Vet. Res. 8: 48. doi: 10.1186/1746-6148-8-48. 22546492 PMC3485124 · DOI
  36. Van Engen N. K., Stock M. L., Engelken T., Vann R. C., Wulf L. W., Karriker L. A., Busby W. D., Lakritz J., Carpenter A. J., Bradford B. J., et al. 2014 Impact of oral meloxicam on circulating physiological biomarkers of stress and inflammation in beef steers after long-distance transportation. J. Anim. Sci. 92: 498– 510. doi: 10.2527/jas.2013-6857. 24664558 · DOI
  37. Van Engen N. K., Platt R., Roth J. A., Stock M. L., Engelken T., Vann R. C., Wulf L. W., Busby W. D., Wang C., Kalkwarf E. M., et al. 2016 Impact of oral meloxicam and long-distance transport on cell-mediated and humoral immune responses in feedlot steers receiving modified live BVDV booster vaccination on arrival. Vet. Immunol. Immunopathol. 175: 42– 50. doi: 10.1016/j.vetimm.2016.05.006. 27269791 · DOI
  38. Van Cauter E., Leproult R., and Kupfer D. J. 1996 Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol. J. Clin. Endocrinol. Metab. 81: 2468– 2473. doi: 10.1210/jcem.81.7.8675562. 8675562 · DOI · Paper page
  39. Wildman B. K., Perrett T., Abutarbush S. M., Guichon P. T., Pittman T. J., Booker C. W., Schunicht O. C., Fenton R. K., and Jim G. K. 2008 A comparison of 2 vaccination programs in feedlot calves at ultra-high risk of developing undifferentiated fever/bovine respiratory disease. Can. Vet. J. 49: 463– 472. 18512457 PMC2359490
  40. Wilson B. K., Step D. L., Maxwell C. L., Wagner J. J., Richards C. J., and Krehbiel C. R. 2015 Evaluation of multiple ancillary therapies used in combination with an antimicrobial in newly received high-risk calves treated for bovine respiratory disease. J. Anim. Sci. 93: 3661– 3674. doi: 10.2527/jas.2015-9023. 26440032 PMC7199660 · DOI

Cited by

Sorted by citations

Authors
Van Engen, N. K., Engelken, T. J., Lockard, C. G., Lakritz, J., Cernicchiaro, N., Wilson, B. K., Krehbiel, C. R., & Coetzee, J. F.
Affiliations
  • Department of Veterinary Diagnostics and Production Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA
  • Iowa State University (US)
  • Oklahoma State University (US)
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Colombus, OH
  • Kansas State University (US)
Corresponding author
  • Krehbiel, Clint R
  • Coetzee, Johann F
ORCID
Venue
Translational Animal Science
Publisher
Oxford University Press (OUP)
Published
2019-03-01
Volume
3
Issue
2
Pages
620-632
ISSN
2573-2102 (ISSN-L)
DOI
10.1093/tas/txz070
PMC
PMC7200945
OpenAlex
W2945622229
Cited by
3
References
2
Citations by year
2025: 1 · 2024: 1 · 2022: 1
FWCI
0.33
Type
journal article
Language
en
Open access
Licence
Locations
  • Translational Animal Science (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Agriculture
  • National Institute of Food and Agriculture
Topics
  • Health Sciences › Veterinary › Small Animals › Animal health and immunology
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
Keywords
meloxicam, bovine respiratory disease, feedlot calves, nonsteroidal anti-inflammatory drugs, substance P, cortisol, morbidity, carcass characteristics, beef cattle performance, crossbred steers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review