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Cited by 33Toxic Organic Pollutants ImpactNeuroendocrine regulation and behaviorElectrolyte and hormonal disorders

Dietary exposure to aroclor 1254 alters central and peripheral vasopressin release in response to dehydration in the rat

Coburn, C. G.·2005·Toxicological Sciences
DOI 10.1093/toxsci/kfi046
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Abstract

Central vasopressin (VP) release from magnocellular neuroendocrine cells (MNCs) in the supraoptic nucleus (SON) occurs from their somata and dendrites within the SON several hours after acute dehydration, and is an important autoregulatory mechanism influencing the systemic release of VP from MNC terminals in the posterior pituitary. To begin to explore the impact of polychlorinated biphenyls (PCBs) on brain mechanisms of body fluid regulation, both central and systemic VP release in response to acute dehydration were assessed in adult male rats fed the commercial PCB mixture Aroclor 1254 (30 mg/kg/day) for 15 days. Water intake and body weight were recorded daily, and on day 15 rats were dehydrated by intraperitoneal injection of 3.5 M saline (controls received physiological saline) and sacrificed 4-6 h later. Intranuclear VP release was measured in SON tissue punches in vitro, and systemic VP release was measured in the same rats. SON prepared from dehydrated PCB-naive rats released significantly more VP than did SON from control rats (4.9 +/- 0.8 vs. 2.7 +/- 0.4 pg/ml/microg). In contrast, while Aroclor 1254 exposure had no effect on baseline water intake, weight gain, or plasma osmolality responses to dehydration in PCB-fed rats, the SON failed to respond with increased VP release during dehydration. Consistent with previous studies showing an inhibitory effect of central VP on plasma VP output, dehydrated PCB-fed rats had an exaggerated 863% increase in plasma VP over ba…

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  • PBDEs impair AVP release from the SON in response to dehydration and disrupt nitric oxide release related to AVP function in rats.

    “Impaired AVP release from the SON in response to dehydration; disruption of nitric oxide release related to AVP function in rats”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [76]

  • PCBs impair AVP release from the SON in response to dehydration in rats.

    “Impaired AVP release from the SON in response to dehydration in rats”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [76]

  • The PCB mixture Aroclor 1254 and PBDEs including DE-71 significantly reduced AVP release from the SON in response to dehydration in adult male rats.

    “Work using adult male rats and SON tissue punches has yielded evidence that the PCB mixture Aroclor 1254 and the structurally related polybrominated flame retardants [polybrominated diphenyl ethers (PBDEs)], including the pentabrominated mixture DE-71, significantly reduced AVP release from the SON in response to dehydration (76, 77).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [76]

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Authors
Coburn, C. G.
Affiliations
University of California, Riverside (US)
Corresponding author
Coburn, C. G.
Venue
Toxicological Sciences
Publisher
Oxford University Press (OUP)
Published
2005-01-05
Volume
84
Issue
1
Pages
149-156
ISSN
1096-0929 (ISSN-L)
DOI
10.1093/toxsci/kfi046
OpenAlex
W2166995303
Cited by
33
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 2 · 2017: 3 · 2015: 2 · 2014: 1 · 2012: 1
FWCI
1.04
Type
journal article
Language
en
Open access
closed
Locations
  • Toxicological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Consejo Nacional de Ciencia y Tecnología
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
Keywords
Aroclor 1254, polychlorinated biphenyls, vasopressin, dehydration, supraoptic nucleus, plasma vasopressin, body fluid regulation, endocrine disruption
MeSH terms
Animals, Central Nervous System, Dehydration, Dendrites, Diet, Male, Neurosecretory Systems, Osmolar Concentration, Supraoptic Nucleus, Vasopressins, Signal Transduction, Peripheral Nervous System, Chlorodiphenyl (54% Chlorine), Rats

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