The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Threshold of Toxicological Concern Concept in Risk Assessment
Abstract
The concept that "safe levels of exposure" for humans can be identified for individual chemicals is central to the risk assessment of compounds with known toxicological profiles. The Threshold of Toxicological Concern (TTC) is a concept that refers to the establishment of a level of exposure for all chemicals, whether or not there are chemical-specific toxicity data, below which there would be no appreciable risk to human health. The concept proposes that a low level of exposure with a negligible risk can be identified for many chemicals, including those of unknown toxicity, based on knowledge of their chemical structures. The present paper aims to describe the history of the TTC principle, its use to date, its potential future applications and the incorporation of the TTC principle in the Risk Assessment paradigm.
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Cites
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Self-citationA procedure for the safety evaluation of flavouring substances
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Kroes, R., Renwick, A. G., Feron, V., Galli, C. L., Gibney, M., Greim, H., Guy, R. H., Lhuguenot, J. C., & van de Sandt, J. J. M. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.06.021 · Cited by 1,856
Self-citationAn in silico skin absorption model for fragrance materials
Shen, J., Kromidas, L., Schultz, T., & Bhatia, S. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.09.015 · Cited by 1,495
Hazardous Compounds in Tobacco Smoke
Talhout, R., Schulz, T., Florek, E., Van Benthem, J., Wester, P., & Opperhuizen, A. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8020613 · Cited by 829
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
Adler, S., Basketter, D., Creton, S., Pelkonen, O., van Benthem, J., Zuang, V., Andersen, K. E., Angers-Loustau, A., Aptula, A., Bal-Price, A., et al. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0693-2 · Cited by 584
Safety assessment of personal care products/cosmetics and their ingredients
Nohynek, G. J., Antignac, E., Re, T., & Toutain, H. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.12.001 · Cited by 489
Metadata
- Authors
- Kroes, R., Kleiner, J., & Renwick, A.
- Venue
- Toxicological Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-13
- Volume
- 86
- Issue
- 2
- Pages
- 226-230
- ISSN
- 1096-0929 (ISSN-L)
- 1096-6080
- OpenAlex
- W2057697580
- Cited by
- 259
- References
- 11
- FWCI
- 16.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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