The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Defining the Mechanisms by Which the Reactive Oxygen Species By-Product, 4-Hydroxynonenal, Affects Human Sperm Cell Function1
Abstract
Lipid peroxidation products such as the naturally occurring aldehyde 4-hydroxynonenal (4-HNE) are known to be cytotoxic toward different cell types, including spermatozoa. In order to understand this at the molecular level, we have employed a proteomic approach to characterize direct 4-HNE adducts on human spermatozoa. Several proteins were identified to be of particular interest, including aldehyde labeling of histone methyltransferase and dynein heavy chain. In addition, we found that 4-HNE bound to part of the activation segment, cysteine residue 199, of protein kinase A (PKA). Interestingly, at low levels, addition of 4-HNE had a stimulatory effect on PKA. However, this did not correlate to increased phosphotyrosine levels during capacitation. This data explains the link between reactive oxygen species and sperm toxicity. Given that epigenetic regulation is likely affected in oxidative-stressed spermatozoa, this data show that spermatozoa appear to shut down under these conditions before reaching the egg.
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Citations
Cites
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
Uchida, K. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00014-6 · Cited by 1,164
Ben Khelifa, M., Coutton, C., Zouari, R., Karaouzène, T., Rendu, J., Bidart, M., Yassine, S., Pierre, V., Delaroche, J., Hennebicq, S., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.11.017 · Cited by 474
Cited by
Causes and consequences of oxidative stress in spermatozoa
Aitken, R. J., Gibb, Z., Baker, M. A., Drevet, J., & Gharagozloo, P. (2015) · Reproduction, Fertility and Development · doi:10.1071/rd15325 · Cited by 428
Self-citationMolecular Changes Induced by Oxidative Stress that Impair Human Sperm Motility
Nowicka-Bauer, K., & Nixon, B. (2020) · Antioxidants · doi:10.3390/antiox9020134 · Cited by 264
Metadata
- Authors
- Baker, M. A., Weinberg, A., Hetherington, L., Villaverde, A.-I., Velkov, T., Baell, J., & Gordon, C. P.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-04-01
- Volume
- 92
- Issue
- 4
- Pages
- 108-108
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2096214321
- Cited by
- 165
- References
- 3
- FWCI
- 19.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Baker, M. A., Weinberg, A., Hetherington, L., Villaverde, A.-I., Velkov, T., Baell, J., & Gordon, C. P. (2015). Defining the Mechanisms by Which the Reactive Oxygen Species By-Product, 4-Hydroxynonenal, Affects Human Sperm Cell Function1. Biology of Reproduction. https://doi.org/10.1095/biolreprod.114.126680
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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