The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of Expression of Steroidogenic Enzymes in Leydig Cells1
Abstract
The Leydig cell of the testis is the only cell in the male that has the capacity to synthesize testosterone from cholesterol. Testosterone is critical during fetal development for male sexual differentiation, and postnatally for initiation and maintenance of spermatogenesis and the expression of the male secondary sex characteristics. The biosynthesis of testosterone requires the activities of four enzymes, cholesterol side-chain cleavage enzyme (P450scc), 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta HSD), 17 alpha-hydroxylase/C17-20 lyase (P450(17 alpha)), and 17-ketosteroid reductase. The expression of these enzymes appears to be regulated by different mechanisms. The recent isolation of the mouse cDNAs and structural genes that encode these enzymes has enabled us to begin to investigate the regulation of their expression at the molecular level. This review discusses the regulation by cAMP and steroids of three enzymes in Leydig cells, P450scc, P450(17 alpha), and 3 beta HSD, as well as characterization of the promoters of the mouse genes that encode P450scc and P450(17 alpha).
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Citations
Cites
Lala, D. S. (1992) · Molecular Endocrinology · doi:10.1210/me.6.8.1249 · Cited by 678
Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Geissler, W. M., Davis, D. L., Wu, L., Bradshaw, K. D., Patel, S., Mendonca, B. B., Elliston, K. O., Wilson, J. D., Russell, D. W., & Andersson, S. (1994) · Nature Genetics · doi:10.1038/ng0594-34 · Cited by 570
VOUTILAINEN, R., & MILLER, W. L. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-5-1145 · Cited by 185
Cited by
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones
Payne, A. H., & Hales, D. B. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0030 · Cited by 1,766
Self-citationRane, S. G., Dubus, P., Mettus, R. V., Galbreath, E. J., Boden, G., Reddy, E. P., & Barbacid, M. (1999) · Nature Genetics · doi:10.1038/8751 · Cited by 700
Hu, J., Zhang, Z., Shen, W.-J., & Azhar, S. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-47 · Cited by 531
Cell Biology of Leydig Cells in the Testis
Haider, S. G. (2004) · International Review of Cytology · doi:10.1016/s0074-7696(04)33005-6 · Cited by 372
Conley, A. J., & Bird, I. M. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.4.789 · Cited by 295
Metadata
- Authors
- Payne, A. H., & Youngblood, G. L.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-02-01
- Volume
- 52
- Issue
- 2
- Pages
- 217-225
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2137516638
- Cited by
- 343
- References
- 3
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Payne, A. H., & Youngblood, G. L. (1995). Regulation of Expression of Steroidogenic Enzymes in Leydig Cells1. Biology of Reproduction. https://doi.org/10.1095/biolreprod52.2.217
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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