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Analysis of Mouse Oocyte Activation Suggests the Involvement of Sperm Perinuclear Material1
Open accessAbstract
The mouse oocyte can be activated by injection of a single, intact mouse spermatozoon or its isolated head. Isolated tails are unable to activate the oocyte. Active sperm-borne oocyte-activating factor(s) (SOAF) appears during transformation of the round spermatid into the spermatozoon. The action of SOAF is not highly species-specific: mouse oocytes are activated by injection of spermatozoa from foreign species, such as the hamster, rabbit, pig, human, and even fish. Some SOAF can be extracted by simple freeze-thawing of (hamster) spermatozoa; additional SOAF is obtained by sequential treatment of spermatozoa with Triton X-100 and SDS. Electron microscopic examination of sperm heads during SOAF extraction suggests that the relatively insoluble SOAF is associated with perinuclear material. When microsurgically injected into oocytes, Triton X-100-treated sperm heads (with perinuclear material, but without any membranes) can activate the oocytes, leading to normal embryonic development. Whereas perinuclear components have been believed to play a purely structural role, these data suggest an additional function for them in oocyte activation.
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Cited by
Egg Activation at Fertilization: Where It All Begins
Runft, L. L., Jaffe, L. A., & Mehlmann, L. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0600 · Cited by 364
Mutations in CCIN cause teratozoospermia and male infertility
Fan, Y., Huang, C., Chen, J., Chen, Y., Wang, Y., Yan, Z., Yu, W., Wu, H., Yang, Y., Nie, L., et al. (2022) · Science Bulletin · doi:10.1016/j.scib.2022.09.026 · Cited by 33
Metadata
- Authors
- Kimura, Y., Yanagimachi, R., Kuretake, S., Bortkiewicz, H., Perry, A. C., & Yanagimachi, H.
- Venue
- Biology of Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-06-01
- Volume
- 58
- Issue
- 6
- Pages
- 1407-1415
- ISSN
- 0006-3363 (ISSN-L)
- 1529-7268
- OpenAlex
- W2186122197
- Cited by
- 212
- References
- 0
- FWCI
- 18.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Analysis of Mouse Oocyte Activation Suggests the Involvement of Sperm Perinuclear Material1. https://app.cochat.ai/papers/10.1095/biolreprod58.6.1407
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- Kimura, Y., Yanagimachi, R., Kuretake, S., Bortkiewicz, H., Perry, A. C., & Yanagimachi, H. (1998). Analysis of Mouse Oocyte Activation Suggests the Involvement of Sperm Perinuclear Material1. Biology of Reproduction. https://doi.org/10.1095/biolreprod58.6.1407
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