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Anchoring proteins for protein kinase C: a means for isozyme selectivity
Abstract
Protein kinase C (PKC) isozymes comprise a family of related enzymes. There are only limited differences between these isozymes in substrate specificity or sensitivity to activators. However, there are multiple isozymes within a cell mediating isozyme-specific functions. Differential subcellular localization has been proposed to explain this specificity. When members of the PKC family are activated by lipid-derived second messengers, they translocate from one cell compartment to another. Isozyme specificity appears to be mediated in part by association of each PKC isozyme with specific anchoring proteins. This review will cover the proteins involved in the anchoring of PKC isozymes at specific subcellular sites, the domains in the PKC isozymes that mediate protein-protein interaction with isozyme-specific anchoring proteins, and identification of peptides that interfere with or promote these protein-protein interactions, thus altering the localization and function of individual isozymes.
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Cited by
Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C
Kamp, T. J., & Hell, J. W. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1095 · Cited by 606
Protein kinase C: poised to signal
Newton, A. C. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00477.2009 · Cited by 512
Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic β-Cell Function
Gilon, P., & Henquin, J.-C. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.5.0440 · Cited by 508
Leonard, A. S., Lim, I. A., Hemsworth, D. E., Horne, M. C., & Hell, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3239 · Cited by 385
Schrijvers, B. F., De Vriese, A. S., & Flyvbjerg, A. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0018 · Cited by 353
Metadata
- Authors
- Mochly-Rosen, D., & Gordon, A. S.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1998-01
- Volume
- 12
- Issue
- 1
- Pages
- 35-42
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1837586904
- Cited by
- 588
- References
- 0
- FWCI
- 21.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mochly-Rosen, D., & Gordon, A. S. (1998). Anchoring proteins for protein kinase C: a means for isozyme selectivity. The FASEB Journal. https://doi.org/10.1096/fasebj.12.1.35
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