The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Is NF‐κB the sensor of oxidative stress?
Abstract
NF‐κB is a dimeric transcription factor that is involved in the regulation of a large number of genes that control various aspects of the immune and inflammatory response. It is activated by a variety of stimuli ranging from cytokines, to various forms of radiation, to oxidative stress (such as exposure to H 2 O 2 ). Recent studies have advanced our understanding of the signal transduction pathway leading to NF‐κB activation by cytokines and will provide insights for the mechanism by which NF‐κB is regulated by oxidative stress. An important question that is yet to be answered is whether reactive oxygen species play a physiological role in NF‐κB activation.—Li, N., Karin, M. Is NF‐κB the sensor of oxidative stress? FASEB J. 13, 1137–1143 (1999)
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Citations
Cites
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125
Self-citationSelective Modification of Glutathione Metabolism
Meister, A. (1983) · Science · doi:10.1126/science.6836290 · Cited by 1,267 · cited 1×
“Buthionine-sulfoximine (BSO) is a drug that causes GSH depletion since it selectively inhibits glutamylcysteine synthetase, the enzyme responsible for GSH synthesis (41).”
Background
Cited by
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Reactive oxygen species in cancer
Liou, G.-Y., & Storz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,382
Carr, A., & Maggini, S. (2017) · Nutrients · doi:10.3390/nu9111211 · Cited by 2,035
NF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,537
Metadata
- Authors
- Li, N., & Karin, M.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1999-07
- Volume
- 13
- Issue
- 10
- Pages
- 1137-1143
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W4319308505
- Cited by
- 701
- References
- 3
- FWCI
- 17.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
