The DOI matches its Crossref record.
A plant‐derived edible vaccine against hepatitis B virus
Abstract
The infectious hepatitis B virus represents 42 nm spherical double‐shelled particles. However, analysis of blood from hepatitis B virus carriers revealed the presence of smaller 22 nm particles consisting of a viral envelope surface protein. These particles are highly immunogenic and have been used in the design of hepatitis B virus vaccine produced in yeast. Upon expression in yeast, these proteins form virus‐like particles that are used for parenteral immunization. Therefore, the DNA fragment encoding hepatitis B virus surface antigen was introduced into Agrobacterium tumerifacience LBA4404 and used to obtain transgenic lupin ( Lupinus luteus L .) and lettuce ( Lactuca sativa L .) cv. Burpee Bibb expressing envelope surface protein. Mice that were fed the transgenic lupin tissue developed significant levels of hepatitis B virus‐specific antibodies. Human volunteers, fed with transgenic lettuce plants expressing hepatitis B virus surface antigen, developed specific serum‐IgG response to plant produced protein.—Kapusta, J., Modelska, A., Figlerowicz, M., Pniewski, T., Letellier, M., Lisowa, O., Yusibov, V., Koprowski, H., Plucienniczak, A., Legocki, A. B. A plant‐derived edible vaccine against hepatitis B virus. FASEB J . 13, 1796–1799 (1999)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Kushnir, N., Streatfield, S. J., & Yusibov, V. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.10.083 · Cited by 587
Self-citationDaniell, H., Lee, S.-B., Panchal, T., & Wiebe, P. O. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4921 · Cited by 398
D’Aoust, M., Couture, M. M. ‐., Charland, N., Trépanier, S., Landry, N., Ors, F., & Vézina, L. (2010) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2009.00496.x · Cited by 371
Genetically modified plants and human health
Key, S., Ma, J. K.-C., & Drake, P. M. (2008) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.2008.070372 · Cited by 197
Metadata
- Authors
- Kapusta, J., Modelska, A., Figlerowicz, M., Pniewski, T., Letellier, M., Lisowa, O., Yusibov, V., Koprowski, H., Plucienniczak, A., & Legocki, A. B.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1999-10
- Volume
- 13
- Issue
- 13
- Pages
- 1796-1799
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1705041761
- Cited by
- 386
- References
- 0
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A plant‐derived edible vaccine against hepatitis B virus. https://app.cochat.ai/papers/10.1096/fasebj.13.13.1796
- The paper
- Kapusta, J., Modelska, A., Figlerowicz, M., Pniewski, T., Letellier, M., Lisowa, O., Yusibov, V., Koprowski, H., Plucienniczak, A., & Legocki, A. B. (1999). A plant‐derived edible vaccine against hepatitis B virus. The FASEB Journal. https://doi.org/10.1096/fasebj.13.13.1796
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
