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Cyclin E in human cancers
Abstract
Regulators of the cell cycle such as cyclin E play an important part in neoplasia. The cyclin E protein forms a partnership with a specific protein kinase. This complex phosphorylates key substrates to initiate DNA synthesis. Cyclin‐dependent kinase inhibitors (CKIs) are able to suppress the activity of cyclin E. Various substances (including proteins produced by oncogenic viruses) affect cyclin E directly or indirectly through an interaction with CKIs. These interactions are important in elucidating the mechanisms of neoplasia. They may also provide prognostic information in a wide range of common cancers. Cyclin E may even be a target for treatment of cancers in the future.—Donnellan, R., Chetty, R. Cyclin E in human cancers. FASEB J. 13, 773–780 (1999)
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Cited by
Strohmaier, H., Spruck, C. H., Kaiser, P., Won, K.-A., Sangfelt, O., & Reed, S. I. (2001) · Nature · doi:10.1038/35095076 · Cited by 583
The Ubiquitin-Proteasome Pathway and Its Role in Cancer
Mani, A., & Gelmann, E. P. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.05.081 · Cited by 549
PIK3CA as an oncogene in cervical cancer
Ma, Y.-Y., Wei, S.-J., Lin, Y.-C., Lung, J.-C., Chang, T.-C., Whang-Peng, J., Liu, J. M., Yang, D.-M., Yang, W. K., & Shen, C.-Y. (2000) · Oncogene · doi:10.1038/sj.onc.1203597 · Cited by 434
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
Duman-Scheel, M., Weng, L., Xin, S., & Du, W. (2002) · Nature · doi:10.1038/417299a · Cited by 434
Veeriah, S., Taylor, B. S., Meng, S., Fang, F., Yilmaz, E., Vivanco, I., Janakiraman, M., Schultz, N., Hanrahan, A. J., Pao, W., et al. (2010) · Nature Genetics · doi:10.1038/ng.491 · Cited by 406
Metadata
- Authors
- Donnellan, R., & Chetty, R.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1999-05
- Volume
- 13
- Issue
- 8
- Pages
- 773-780
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1868874850
- Cited by
- 206
- References
- 0
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
