The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis
Open accessAbstract
In mammals, liver perisinusoidal stellate cells play an important role as a main store of body retinol (vitamin A). This fat‐soluble vitamin is essential for vision, and regulates differentiation and growth of many cell types during embryonal development as well as in adult tissues. Thus, many cell types require a continuous supply of retinol. The storage of retinol (as retinyl esters) in stellate cells ascertains ample access of retinol to such cells also during periods with a low dietary intake. In lower vertebrates such as fish, vitamin A‐storing stellate cells are found not only in the hepatic lobule, but also in the connective tissues of organs like intestine, kidney, ovaries, testes, and gills. Extrahepatic vitamin A‐storing stellate cells are found in higher vertebrates when excessive doses of vitamin A are administered. It is not clear at present whether these cells also play a role in retinol metabolism under normal conditions. Stellate cells proliferate in a fibrotic liver, and they have been found to synthesize connective tissue compounds such as collagen. It was recently demonstrated that stellate cells are the principal cellular source of collagen and other extracellular substances in normal as well as fibrotic livers. Therefore, stellate cells, which seem to be a specialized type of pericyte, have a central role in the pathological changes observed during the development of liver fibrosis.—Blomhoff, R.; Wake, K. Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J. 5: 271–277; 1991.
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Cites
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.
Friedman, S. L., Roll, F. J., Boyles, J., & Bissell, D. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8681 · Cited by 859
Transport and Storage of Vitamin A
Blomhoff, R., Green, M. H., Berg, T., & Norum, K. R. (1990) · Science · doi:10.1126/science.2218545 · Cited by 611
Self-citationWake, K. (1980) · International Review of Cytology · doi:10.1016/s0074-7696(08)61977-4 · Cited by 531
Self-citationPinzani, M., Gesualdo, L., Sabbah, G. M., & Abboud, H. E. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114363 · Cited by 478
Immunocytochemical Detection of Desmin in Fat-Storing Cells (Ito Cells)
Yokoi, Y., Namihisa, T., Kuroda, H., Komatsu, I., Miyazaki, A., Watanabe, S., & Usui, K. (1984) · Hepatology · doi:10.1002/hep.1840040425 · Cited by 388
“Sternzellen” in the liver: Perisinusoidal cells with special reference to storage of vitamin A
Wake, K. (1971) · American Journal of Anatomy · doi:10.1002/aja.1001320404 · Cited by 388
Self-citationFriedman, S. L., Roll, F. J., Boyles, J., Arenson, D. M., & Bissell, D. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81686-6 · Cited by 354
Purified Rat Liver Fat-Storing Cells in Culture Divide and Contain Collagen
De Margreet Leeuw, A., Mccarthy, S. P., Geerts, A., & Knook, D. L. (1984) · Hepatology · doi:10.1002/hep.1840040307 · Cited by 326
PLASMA RETINOL‐BINDING PROTEIN*
Goodman, D. S. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb21314.x · Cited by 276
Plasma Retinol-Binding Protein
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Cited by
Identification, culture, and characterization of pancreatic stellate cells in rats and humans
Bachem, M. G., Schneider, E., Groß, H., Weidenbach, H., Schmid, R. M., Menke, A., Siech, M., Beger, H., Grünert, A., & Adler, G. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70209-4 · Cited by 1,018
Hepatocyte growth factor gene therapy of liver cirrhosis in rats
Ueki, T., Kaneda, Y., Tsutsui, H., Nakanishi, K., Sawa, Y., Morishita, R., Matsumoto, K., Nakamura, T., Takahashi, H., Okamoto, E., et al. (1999) · Nature Medicine · doi:10.1038/5593 · Cited by 587
Galli, A., Crabb, D. W., Ceni, E., Salzano, R., Mello, T., Svegliati–Baroni, G., Ridolfi, F., Trozzi, L., Surrenti, C., & Casini, A. (2002) · Gastroenterology · doi:10.1053/gast.2002.33666 · Cited by 440
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells
Trivedi, P., Wang, S., & Friedman, S. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.026 · Cited by 427
Lipid nanoparticle technology for therapeutic gene regulation in the liver
Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.026 · Cited by 376
Metadata
- Authors
- Blomhoff, R., & Wake, K.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1991-03
- Volume
- 5
- Issue
- 3
- Pages
- 271-277
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1538483334
- Cited by
- 388
- References
- 34
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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