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The structure and evolution of a/β barrel proteins
Abstract
Roughly 10% of all known enzyme structures have an α/β barrel domain. The members of this large family of proteins catalyze very different types of reactions. Such diversity of function has made this family a target for protein engineering. The evolutionary history of this family has been the subject of vigorous debate. In this paper, arguments are made to support the divergence of all members of this family from a common ancestor. Because of the lack of strong sequence homology, the ancestral molecule must be very old. A hypothesis concerning the relationship between chemical mechanism and evolutionary history is discussed. Evidence is presented to suggest that convergent molecular evolution occurs when there is only one energetically reasonable pathway for a chemical reaction.—Reardon, D., Farber, G. K. The structure and evolution of α/β barrel proteins. FASEB J. 9, 497–503 (1995)
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Cited by
Payne, C. M., Knott, B. C., Mayes, H. B., Hansson, H., Himmel, M. E., Sandgren, M., Ståhlberg, J., & Beckham, G. T. (2015) · Chemical Reviews · doi:10.1021/cr500351c · Cited by 855
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Christianson, D. W. (2006) · Chemical Reviews · doi:10.1021/cr050286w · Cited by 788
Lesburg, C. A., Zhai, G., Cane, D. E., & Christianson, D. W. (1997) · Science · doi:10.1126/science.277.5333.1820 · Cited by 454
Sousa, F. L., & Martin, W. F. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.02.001 · Cited by 100
Metadata
- Authors
- Reardon, D., & Farber, G. K.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1995-04
- Volume
- 9
- Issue
- 7
- Pages
- 497-503
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1505216348
- Cited by
- 160
- References
- 0
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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