The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma
Abstract
Asthma is characterized by airway inflammation, remodeling, and hyperresponsiveness to contractile stimuli that promote airway constriction and wheezing. Here we present evidence that sphingosine 1‐phosphate (SPP) is a potentially important inflammatory mediator implicated in the pathogenesis of airway inflammation and asthma. SPP levels were elevated in the airways of asthmatic (but not control) subjects following segmental antigen challenge, and this increase was correlated with a concomitant increase in airway inflammation. Because human airway smooth muscle (ASM) cells expressed EDG receptors for SPP (EDG‐1, ‐3, ‐5, and ‐6), we examined whether SPP may play a role in airway inflammation and remodeling, by affecting ASM cell growth, contraction, and cytokine secretion. SPP is mitogenic and augments EGF‐ and thrombin‐induced DNA proliferation by increasing G 1 /S progression. SPP increased phosphoinositide turnover and intracellular calcium mobilization, the acute signaling events that affect ASM contraction. By modulating adenylate cyclase activity and cAMP accumulation, SPP had potent effects on cytokine secretion. Although SPP inhibited TNF‐α–induced RANTES release, it induced substantial IL‐6 secretion alone and augmented production of IL‐6 induced by TNF‐α. These studies are the first to associate SPP with airway inflammation and to identify SPP as an effective regulator of ASM growth, contraction and synthetic functions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Guidelines for the diagnosis and management of asthma.
Solomon, P. A. (1992) · PubMed · Cited by 2,004
Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1
Lee, M.-J., Van Brocklyn, J. R., Thangada, S., Liu, C. H., Hand, A. R., Menzeleev, R., Spiegel, S., & Hla, T. (1998) · Science · doi:10.1126/science.279.5356.1552 · Cited by 1,007
Self-citationCytokines in symptomatic asthma airways
Broide, D. H., Lotz, M., Cuomo, A. J., Coburn, D. A., Federman, E. C., & Wasserman, S. I. (1992) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(92)90218-q · Cited by 736
Sphingosine 1-phosphate signalling in mammalian cells
Pyne, S., & Pyne, N. J. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490385 · Cited by 735
Hecht, J. H., Weiner, J. A., Post, S. R., & Chun, J. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.4.1071 · Cited by 720
Elias, J. A., Zhu, Z., Chupp, G., & Homer, R. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8124 · Cited by 702
Dunnill, M. S., Massarella, G. R., & Anderson, J. (1969) · Thorax · doi:10.1136/thx.24.2.176 · Cited by 697
Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid
An, S., Bleu, T., Hallmark, O. G., & Goetzl, E. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.7906 · Cited by 528
Bandoh, K., Aoki, J., Hosono, H., Kobayashi, S., Kobayashi, T., Murakami-Murofushi, K., Tsujimoto, M., Arai, H., & Inoue, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27776 · Cited by 511
Van Brocklyn, J. R., Lee, M.-J., Menzeleev, R., Olivera, A., Edsall, L., Cuvillier, O., Thomas, D. M., Coopman, P. J. P., Thangada, S., Liu, C. H., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.229 · Cited by 460
Self-citation
Cited by
“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets
Takabe, K., Paugh, S. W., Milstien, S., & Spiegel, S. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07113 · Cited by 718
Self-citationThe alliance of sphingosine-1-phosphate and its receptors in immunity
Rivera, J., Proia, R. L., & Olivera, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2400 · Cited by 616
Orm family proteins mediate sphingolipid homeostasis
Breslow, D. K., Collins, S. R., Bodenmiller, B., Aebersold, R., Simons, K., Shevchenko, A., Ejsing, C. S., & Weissman, J. S. (2010) · Nature · doi:10.1038/nature08787 · Cited by 599
New developments in FcεRI regulation, function and inhibition
Kraft, S., & Kinet, J.-P. (2007) · Nature Reviews Immunology · doi:10.1038/nri2072 · Cited by 579
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
Mitra, P., Oskeritzian, C. A., Payne, S. G., Beaven, M. A., Milstien, S., & Spiegel, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603734103 · Cited by 407
Self-citation
Metadata
- Authors
- Ammit, A. J., Hastie, A. T., Edsall, L. C., Hoffman, R. K., Amrani, Y., Krymskaya, V. P., Kane, S. A., Peters, S. P., Penn, R. B., Spiegel, S., & Panettieri, R. A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2001-03-20
- Volume
- 15
- Issue
- 7
- Pages
- 1212-1214
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2140053474
- Cited by
- 313
- References
- 54
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. https://app.cochat.ai/papers/10.1096/fj.00-0742fje
- The paper
- Ammit, A. J., Hastie, A. T., Edsall, L. C., Hoffman, R. K., Amrani, Y., Krymskaya, V. P., Kane, S. A., Peters, S. P., Penn, R. B., Spiegel, S., & Panettieri, R. A. (2001). Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. The FASEB Journal. https://doi.org/10.1096/fj.00-0742fje
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
