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2‐Aminoethoxydiphenyl borate (2‐APB) is a reliable blocker of store‐operated Ca 2+ entry but an inconsistent inhibitor of InsP 3 ‐induced Ca 2+ release
Open accessAbstract
Since its introduction to Ca 2+ signaling in 1997, 2‐aminoethoxydiphenyl borate (2‐APB) has been used in many studies to probe for the involvement of inositol 1,4,5‐trisphosphate receptors in the generation of Ca 2+ signals. Due to reports of some nonspecific actions of 2‐APB, and the fact that its principal antagonistic effect is on Ca 2+ entry rather than Ca 2+ release, this compound may not have the utility first suggested. However, 2‐APB has thrown up some interesting results, particularly with respect to store‐operated Ca 2+ entry in nonexcitable cells. These data indicate that although it must be used with caution, 2‐APB can be useful in probing certain aspects of Ca 2+ signaling.—Bootman, M. D., Collins, T. J., Mackenzie, L., Roderick, H. L., Berridge, M. J., Peppiatt, C. M. 2‐Aminoethoxydiphenyl borate (2‐APB) is a reliable blocker of store‐operated Ca 2+ entry but an inconsistent inhibitor of InsP 3 ‐induced Ca 2+ release. FASEB J . 16, 1145–1150 (2002)
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Cited by
2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
Hu, H.-Z., Gu, Q., Wang, C., Colton, C. K., Tang, J., Kinoshita-Kawada, M., Lee, L.-Y., Wood, J. D., & Zhu, M. X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404164200 · Cited by 517
Lucas, P., Ukhanov, K., Leinders-Zufall, T., & Zufall, F. (2003) · Neuron · doi:10.1016/s0896-6273(03)00675-5 · Cited by 323
Astroglial Excitability and Gliotransmission: An Appraisal of Ca 2+ as a Signalling Route
Zorec, R., Araque, A., Carmignoto, G., Haydon, P. G., Verkhratsky, A., & Parpura, V. (2012) · ASN Neuro · doi:10.1042/an20110061 · Cited by 264
Juszczak, G. R., & Swiergiel, A. H. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.12.014 · Cited by 211
Liu, Y.-J., Vieira, E., & Gylfe, E. (2004) · Cell Calcium · doi:10.1016/j.ceca.2003.10.002 · Cited by 118
Metadata
- Authors
- Bootman, M. D., Collins, T. J., Mackenzie, L., Roderick, H. L., Berridge, M. J., & Peppiatt, C. M.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2002-08
- Volume
- 16
- Issue
- 10
- Pages
- 1145-1150
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2117226055
- Cited by
- 692
- References
- 0
- FWCI
- 17.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Bootman, M. D., Collins, T. J., Mackenzie, L., Roderick, H. L., Berridge, M. J., & Peppiatt, C. M. (2002). 2‐Aminoethoxydiphenyl borate (2‐APB) is a reliable blocker of store‐operated Ca 2+ entry but an inconsistent inhibitor of InsP 3 ‐induced Ca 2+ release. The FASEB Journal. https://doi.org/10.1096/fj.02-0037rev
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